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All displayed T6SS gene clusters and T6SS-related proteins were experimentally validated, except that a few protein-related T6SSs were bioinformatically predicted.


experimental Experimental investigation has been performed.
insolico Bioinformatically prediction has been performed.
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SecReT6 ID
Type
Organism
Replicon (Accession)
Location
Function
T6SS00061 experimentali4bAcinetobacter sp. ADP1chromosome (NC_005966)2633143..2661510effector translocation
T6SS01046 experimentali4bAcinetobacter baumannii ATCC 17978chromosome (NZ_CP012004)2433628..2461317anti-bacterial
T6SS00003 experimentali3Pseudomonas aeruginosa PAO1chromosome (H1-T6SS) (NC_002516)83380..123495anti-bacterial; anti-eukaryotic; effector translocation; virulence
T6SS00004 experimentali1Pseudomonas aeruginosa PAO1chromosome (H2-T6SS) (NC_002516)1797958..1827821anti-eukaryotic; anti-bacterial; effector translocation; virulence
T6SS00005 experimentali4aPseudomonas aeruginosa PAO1chromosome (H3-T6SS) (NC_002516)2599893..2632231anti-eukaryotic; anti-bacterial; effector translocation; virulence
T6SS00790 experimentali1Vibrio cholerae V52chromosome (NZ_KQ410497)202021..225793anti-bacterial; anti-eukaryotic; effector translocation; virulence; adherence
T6SS00929 experimentali3Serratia marcescens subsp. marcescens Db11chromosome I (HG326223)2365124..2402670anti-bacterial
T6SS01206 experimentalivCandidatus Amoebophilus asiaticus 5a2chromosome (NC_010830)713229..728788-
T6SS01207 experimentalivCandidatus Amoebophilus asiaticus 5a2chromosome (NC_010830)1380571..1401622-
T6SS01276 experimentali4bBurkholderia cenocepacia strain K56-2chromosome (NZ_LAUA01000004)63074..82939anti-eukaryotic
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experimental Experimental investigation has been performed.
insolico Bioinformatically prediction has been performed.
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SecReT6 ID
Locus tag (Gene)
Related T6SS
Regulator type
Regulatory pathway
Target (Regulation)
Organism                
Replicon
(Accession)
Coordinates (Strand)
NCBI ID
REG0001 experimentalvfu_A02134 (ihfA)T6SS00529 insolico; T6SS00530 insolicoproteinTranscription regulatortssD2_a promoter (↓); VflT6SS2 major cluster promoter (↓)Vibrio furnissii NCTC 11218chromosome (NC_016602)2226951..2227244 (-)490864172
REG0002 experimentalvfu_A02422 (ihfB)T6SS00529 insolico; T6SS00530 insolicoproteinTranscription regulatortssD2_a promoter (↓); VflT6SS2 major cluster promoter (↓)Vibrio furnissii NCTC 11218chromosome (NC_016602)2516092..2516376 (-)490864456
REG0003 experimentalRT90_01105 (rcsC)T6SS01264 experimentalproteinTCS-HKRT90_01115 (rcsB) (↑)Serratia marcescens strain RM66262chromosome (JWLO01000001)232638..235499 (+)735006326
REG0004 experimentalRT90_01115 (rcsB)T6SS01264 experimentalproteinTCS-RRvgrG promoter (↓)Serratia marcescens strain RM66262chromosome (JWLO01000001)235561..236211 (-)735006328
REG0005 experimentalRT90_16255 (wecG)T6SS01264 experimentalproteinTCS regulatory pathwayRT90_01105 (rcsC) (↑)Serratia marcescens strain RM66262chromosome (JWLO01000003)92056..92796 (-)735005313
REG0006 experimentalL085_RS13655 (ppka)T6SS01033 experimentalproteinTppUnknown (↓)Serratia sp. FS14chromosome (NZ_CP005927)3028273..3029718 (-)763151328
REG0007 experimentalY880_04683 (pnp)T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimentalproteinRsmA regulatory pathwayPA0527.1 (RsmY) (↑); PA3621.1 (RsmZ) (↑)Pseudomonas aeruginosa PAKchromosome (NZ_CP020659)4637120..4639225 (-)489185761
REG0008 experimentalPA0527.1 (RsmY)T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimentalncRNARsmA regulatory pathwayRsmA (Y880_06257) (↓)Pseudomonas aeruginosa PAO1chromosome (NZ_CP020659)586867..586990 (+)-
REG0009 experimentalPA3621.1 (RsmZ)T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimentalncRNARsmA regulatory pathwayRsmA (Y880_06257) (↓)Pseudomonas aeruginosa PAO1chromosome (NZ_CP020659)4057543..4057658 (-)-
REG0010 experimentalY880_06257 (rsmA)T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimentalproteinRsmA regulatory pathwayPA4492 mRNA (↑)Pseudomonas aeruginosa PAKchromosome (NZ_CP020659)6213838..6214644 (-)510932573
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experimental Experimental investigation has been performed.
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SecReT6 ID
Locus tag (Gene)
Function type
Cognate immunity protein
Related T6SS
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
EFF01497 experimentalBf638R_1979 (Bfe2)TmeIMU00312 experimentalT6SS00926 experimentalBacteroides fragilis 638Rchromosome (NC_016776)2336050..2339019 (-)504064731
EFF01503 experimentalSMDB11_1112 (Ssp3)Tme-T6SS00929 experimentalSerratia marcescens subsp. marcescens Db11chromosome (HG326223)1178412..1178963 (+)560172958
EFF01506 experimentalSMDB11_4673 (Ssp6)Tme-T6SS00929 experimentalSerratia marcescens subsp. marcescens Db11chromosome (HG326223)5022150..5022797 (-)560176492
EFF01514 experimentalSMDB11_1083 (Tfe2)Tme-T6SS00929 experimentalSerratia marcescens subsp. marcescens Db11chromosome (HG326223)1147856..1148536 (+)560172929
EFF01474 experimentalPFL_6096 (rhsA)TdeIMU00300 experimentalT6SS00035 experimentalPseudomonas protegens Pf-5chromosome (NC_004129)6925413..6929873 (+)68347678
EFF01038 experimentalPA14_01140 (Tas1)TasIMU00310 experimentalT6SS00150 experimentalPseudomonas aeruginosa UCBPP-PA14chromosome (NC_008463)111195..112577 (-)116053814
EFF01453 experimentalZ1921Tse-T6SS00006 insolicoEscherichia coli O157:H7 str. EDL933chromosome (NC_002655)1744916..1745806 (-)15801381
EFF01469 experimentalACIAD_RS00270TpeIMU00293 experimentalT6SS00061 experimentalAcinetobacter baylyi ADP1chromosome (NC_005966)55985..56617 (+)50083347
EFF01496 experimentalPA0262 (VgrG2b)TpeIMU00315 experimentalT6SS00004 experimentalPseudomonas aeruginosa PAO1chromosome (NC_002516)293802..296861 (-)15595459
EFF00200 experimentalAHA_RS05640 (VgrG1)Tre-T6SS00157 experimentalAeromonas hydrophila subsp. hydrophila ATCC 7966chromosome (NC_008570)1212752..1215535 (+)117619461
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experimental Experimental investigation has been performed.
insolico Bioinformatically prediction has been performed.
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SecReT6 ID
Locus tag (Gene)
Cognate effector
Related T6SS
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
IMU00044 experimentalPA5086EFF01279 experimentalT6SS00005 experimentalPseudomonas aeruginosa PAO1chromosome (NC_002516)5724601..5725242 (-)15600279
IMU00045 experimentalPA5087EFF01279 experimentalT6SS00005 experimentalPseudomonas aeruginosa PAO1chromosome (NC_002516)5725479..5726348 (-)15600280
IMU00046 experimentalPA5088EFF01279 experimentalT6SS00005 experimentalPseudomonas aeruginosa PAO1chromosome (NC_002516)5726357..5727238 (-)15600281
IMU00051 experimentalVP_RS06750EFF01293 experimentalT6SS00043 experimentalVibrio parahaemolyticus RIMD 2210633chromosome (NC_004603)1485278..1486405 (+)28898163
IMU00052 experimentalVP_RS06880EFF01294 experimentalT6SS00043 experimentalVibrio parahaemolyticus RIMD 2210633chromosome (NC_004603)1524323..1524916 (+)28898190
IMU00053 experimentalAtu4351 (Tdi1)EFF00996 experimentalT6SS00016 experimentalAgrobacterium fabrum str. C58chromosome (NC_003063)1485765..1486439 (+)15890632
IMU00054 experimentalAtu3639 (Tdi2)EFF01307 experimentalT6SS00016 experimentalAgrobacterium fabrum str. C58chromosome (NC_003063)691507..692238 (-)159185838
IMU00055 experimentalECL_01568 (RhsIA)EFF01254 experimentalT6SS00395 experimentalEnterobacter cloacae subsp. cloacae ATCC 13047chromosome (NC_014121)1595931..1596929 (+)296101930
IMU00056 experimentalECL_03139 (RhsIB)EFF01255 experimentalT6SS00395 experimentalEnterobacter cloacae subsp. cloacae ATCC 13047chromosome (NC_014121)3199746..3200309 (-)296103478
IMU00057 experimentalFjoh_3256 (Fti1)EFF01311 experimentalT6SS00910 experimentalFlavobacterium johnsoniae UW101chromosome (NC_009441)3895387..3895947 (-)146301000
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experimental Experimental investigation has been performed.
insolico Bioinformatically prediction has been performed.
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SecReT6 ID          
Locus tag (Gene)
Response to
T6SS attack
Known or putative function
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
RSF000001 experimentalBW25113_RS11580 (RcsB/ymgA)protectiveRcsB regulon; response envelope stressEscherichia coli BW25113 strain K-12chromosome (NZ_CP009273)2309656..2310306 (+)446984661
RSF000002 experimentalBW25113_RS11585 (RcsC)protectiveRcsB regulon; response envelope stressEscherichia coli BW25113 strain K-12chromosome (NZ_CP009273)2310506..2313355 (-)446798755
RSF000003 experimentalBW25113_RS00985 (RcsF)protectiveRcsB regulon; response envelope stressEscherichia coli BW25113 strain K-12chromosome (NZ_CP009273)216078..216482 (-)447125073
RSF000004 experimentalBW25113_RS10750 (wcaA)protectiveRcsB regulon response envelope stressEscherichia coli BW25113 strain K-12chromosome (NZ_CP009273)2126039..2126878 (-)446717386
RSF000005 experimentalBW25113_RS00275 (surA)protectiveMenbtane integrityEscherichia coli BW25113 strain K-12chromosome (NZ_CP009273)53416..54702 (-)446723144
RSF000006 experimentalBW25113_RS03235 (pagP)protectiveMenbtane integrityEscherichia coli BW25113 strain K-12chromosome (NZ_CP009273)652013..652573 (+)447025838
RSF000007 experimentalBW25113_RS00460 (ddlB)protectivepeptidoglycan synthesisEscherichia coli BW25113 strain K-12chromosome (NZ_CP009273)98720..99640 (+)446052201
RSF000008 experimentalBW25113_RS10855 (BaeR)protectiveenvelope stress responseEscherichia coli BW25113 strain K-12chromosome (NZ_CP009273)2157757..2158479 (+)446060022
RSF000009 experimentalBW25113_RS18230 (gadA)protectiveAcid stress responseEscherichia coli BW25113 strain K-12chromosome (NZ_CP009273)3659540..3660940 (-)446294385
RSF000010 experimentalBW25113_RS07825 (gadB)protectiveAcid stress responseEscherichia coli BW25113 strain K-12chromosome (NZ_CP009273)1564902..1566302 (-)446281075
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experimental Experimental investigation has been performed.
insolico Bioinformatically prediction has been performed.
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SecReT6 ID
Locus tag (Gene)
Related T6SS
Type            
Related
structure protein
Related effector
Organism                
Replicon
(Accession)
Coordinates (Strand)
NCBI ID
ACP00001 experimentalVC1417T6SS00002 experimentaladaptorVgrG-1VC1418 (TseL)Vibrio cholerae O1 biovar El Tor str. N16961chromosome (NC_002505)1513748..1514608 (+)15641428
ACP00002 experimentalPA0094 (eagT6)T6SS00003 experimentaladaptor-PA0093 (Tse6)Pseudomonas aeruginosa PAO1chromosome (NC_002516)114611..115045 (-)15595292
ACP00003 experimentalPA0086 (tagJ)T6SS00003 experimentalstructure affiliated proteinPA0082 (TssA)-Pseudomonas aeruginosa PAO1chromosome (NC_002516)104006..104851 (+)15595284
ACP00004 experimentalPA0086 (tagJ)T6SS00003 experimentalstructure affiliated proteinPA0083 (HisB1/TssB1)-Pseudomonas aeruginosa PAO1chromosome (NC_002516)104006..104851 (+)15595284
ACP00005 experimentalPA0259 (tla3)T6SS00004 experimentaladaptorPA0262 (VgrG2b)PA0260 (Tle3)Pseudomonas aeruginosa PAO1chromosome (NC_002516)289562..291004 (-)15595456
ACP00006 experimentalPA3906 (co-TecT)T6SS00005 experimentalchaperonePA3905 (TecT)-Pseudomonas aeruginosa PAO1chromosome (NC_002516)4374850..4375233 (+)15599101
ACP00007 experimentalPA3905 (tecT)T6SS00005 experimentalchaperonePA3904 (PAAR4)PA3907 (TseT)Pseudomonas aeruginosa PAO1chromosome (NC_002516)4374330..4374857 (+)15599100
ACP00008 experimentalPA3790 (oprC)T6SS00005 experimentalchaperone-PA4922 (Azu)Pseudomonas aeruginosa PAO1chromosome (NC_002516)4247703..4249874 (-)15598985
ACP00009 experimentalPP_RS16060 (tagB1)T6SS00014 experimentalstructure affiliated proteinPP_RS15990 (TssA)-Pseudomonas putida KT2440chromosome (NC_002947)3496832..3497581 (-)898330878
ACP00010 experimentalAtu4349 (tap-1)T6SS00016 experimentaladaptorAtu4348 (VgrG1)Atu4350 (Tde1)Agrobacterium fabrum str. C58chromosome (NC_003063)1483948..1484904 (+)737273750
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