Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01293  |
| T6SS type | Type i3 |
| Strain | Burkholderia pseudomallei K96243 |
| Replicon (GenBank) | chromosome II (CP009537) |
| Location | 1914678..1943867 |
| Function | - |
| Comment | The LD50 values for the Δhcp2 through Δhcp6 mutants were indistinguishable from that of the wild type, suggesting that T6SS-2, T6SS-3, T6SS-4, T6SS-5, and T6SS-6 are not required for virulence in this animal model of infection. |
| References | [1] Burtnick MN et al (2011) The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| AQ15_5051 | 1911328..1911900 | + | 573 | 772958105 | fimbrial family protein | ||
| AQ15_5052 | 1911932..1912621 | + | 690 | 772956745 | hypothetical protein | ||
| AQ15_5053 | 1912624..1914300 | + | 1677 | 772957620 | ompA family protein | ||
| T6CP013066 | TssB | AQ15_5054 | 1914678..1915217 | + | 540 | 772956454 | hypothetical protein |
| T6CP013067 | TssC | AQ15_5055 | 1915251..1916750 | + | 1500 | 772956788 | hypothetical protein |
| T6CP013068 | TssD | AQ15_5056 | 1916950..1917432 | + | 483 | 772956989 | type VI secretion system effector, Hcp1 family protein |
| T6CP013069 | TssJ | AQ15_5057 | 1917560..1918102 | + | 543 | 772958673 | type VI secretion lipofamily protein |
| T6CP013070 | TssK | AQ15_5058 | 1918108..1919457 | + | 1350 | 772957103 | hypothetical protein |
| T6CP013071 | TssL | AQ15_5059 | 1919454..1920755 | + | 1302 | 772956999 | type VI secretion system peptidoglycan-associated domain protein |
| T6CP013072 | TssM | AQ15_5060 | 1920770..1924678 | + | 3909 | 772958378 | intracellular multiplication and macrophage-killing family protein |
| AQ15_5061 | 1924868..1925437 | + | 570 | 772958420 | hypothetical protein | ||
| T6CP013073 | TssI | AQ15_5062 | 1925535..1928201 | + | 2667 | 772956930 | Rhs element Vgr family protein |
| AQ15_5063 | 1928276..1928545 | + | 270 | 772958569 | PAAR motif family protein | ||
| AQ15_5065 | 1928558..1932010 | + | 3453 | 772957676 | RHS repeat-associated core domain protein | ||
| AQ15_5064 | 1931903..1933261 | - | 1359 | 772957125 | glycosyltransferase family protein | ||
| AQ15_5066 | 1933294..1934322 | - | 1029 | 772957070 | fimbrial family protein | ||
| T6CP013074 | TssA | AQ15_5067 | 1934377..1935447 | - | 1071 | 772958443 | hypothetical protein |
| T6CP013075 | TssG | AQ15_5068 | 1935466..1936515 | - | 1050 | 772958127 | hypothetical protein |
| T6CP013076 | TssF | AQ15_5069 | 1936512..1938392 | - | 1881 | 772958782 | hypothetical protein |
| T6CP013077 | TssE | AQ15_5070 | 1938394..1938912 | - | 519 | 772956528 | 25-like lysozyme family protein |
| AQ15_5071 | 1938899..1939753 | - | 855 | 772958746 | impE family protein | ||
| AQ15_5072 | 1939737..1940792 | - | 1056 | 772958257 | hypothetical protein | ||
| T6CP013078 | TssH | AQ15_5073 (clpV) | 1941222..1943867 | + | 2646 | 772958178 | type VI secretion ATPase, ClpV1 family |
| AQ15_5074 | 1944258..1947302 | - | 3045 | 772957026 | response regulator | ||
| AQ15_5075 | 1948088..1948282 | - | 195 | 772958528 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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