Function types of effectors (T6SEs)

Target Location Function Type No. of Experimentally validated Function Mechanism
Periplasmic effectors Tle Type VI Lipase Effector 22 Tle degrade membrane phospholipids.
Tae Type VI Amidase Effector 26 Tae degrade the peptidoglycan through amidase hydrolase activities.
Tge Type VI Glycoside hydrolase Effector 9 Tge degrade the peptidoglycan through glycoside hydrolase activities.
Tme Type VI Membrane-disrupting Effector 13 Tme form pores in the inner membrane, leading to membrane depolarization.
Tpe Type VI Peptidase Effector 9 One member of the Tpe family was proposed to hydrolyze the lipid anchor of outer membrane lipoproteins.
Cytoplasmic effectors Tas Type VI Effector (p)ppApp Synthetase 1 Tas1 phosphorylates ATP and ADP leading to the accumulation of (p)ppApp.
Tne Type VI NADase Effector 3 Tne degrade NAD(P) + to nicotinamide and ADP-ribose, leading to the depletion of NAD(P) + cellular pools.
Tde Type VI DNase and RNase Effector 47 Tde catalyze hydrolysis of nucleic acid (most catalyze hydrolysis of deoxyribonucleic acid, and part hydrolyse RNA).
DddA DS-DNA Deaminase toxin A 2 DddA deaminates cytosine to uracil in the double-stranded DNA.
Tre Type VI ADP-Ribosyltransferase Effector 3 Tre is ADP-ribosyltransferase, transferring the ADP-ribose moiety on protein targets upon hydrolysis of NAD+.
Enviromental effectors Tie Type VI Metal Ion acquisition Effector 7 Tie facilitates the metal ion acquisition of bacterial cell.
Unclassified Tse Type VI Secretion System Effector 51