Function types of effectors (T6SEs)
| Target Location | Function Type | No. of Experimentally validated | Function Mechanism | |
| Periplasmic effectors | Tle | Type VI Lipase Effector | 22 | Tle degrade membrane phospholipids. |
| Tae | Type VI Amidase Effector | 26 | Tae degrade the peptidoglycan through amidase hydrolase activities. | |
| Tge | Type VI Glycoside hydrolase Effector | 9 | Tge degrade the peptidoglycan through glycoside hydrolase activities. | |
| Tme | Type VI Membrane-disrupting Effector | 13 | Tme form pores in the inner membrane, leading to membrane depolarization. | |
| Tpe | Type VI Peptidase Effector | 9 | One member of the Tpe family was proposed to hydrolyze the lipid anchor of outer membrane lipoproteins. | |
| Cytoplasmic effectors | Tas | Type VI Effector (p)ppApp Synthetase | 1 | Tas1 phosphorylates ATP and ADP leading to the accumulation of (p)ppApp. |
| Tne | Type VI NADase Effector | 3 | Tne degrade NAD(P) + to nicotinamide and ADP-ribose, leading to the depletion of NAD(P) + cellular pools. | |
| Tde | Type VI DNase and RNase Effector | 47 | Tde catalyze hydrolysis of nucleic acid (most catalyze hydrolysis of deoxyribonucleic acid, and part hydrolyse RNA). | |
| DddA | DS-DNA Deaminase toxin A | 2 | DddA deaminates cytosine to uracil in the double-stranded DNA. | |
| Tre | Type VI ADP-Ribosyltransferase Effector | 3 | Tre is ADP-ribosyltransferase, transferring the ADP-ribose moiety on protein targets upon hydrolysis of NAD+. | |
| Enviromental effectors | Tie | Type VI Metal Ion acquisition Effector | 7 | Tie facilitates the metal ion acquisition of bacterial cell. |
| Unclassified | Tse | Type VI Secretion System Effector | 51 | |