Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00061  |
| T6SS type | Type i4b |
| Strain | Acinetobacter sp. ADP1 |
| Replicon (RefSeq) | chromosome (NC_005966) |
| Location | 2633143..2661510 |
| Function | effector translocation |
| Comment | - |
| References | [1] Weber BS et al (2013) Genomic and Functional Analysis of the Type VI Secretion System in Acinetobacter. PLoS One. 8(1):e55142. [PudMed:23365692] [2] Shneider MM et al (2013) PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature. 500(7462):350-3. [PudMed:23925114] [3] Basler M et al (2013) Tit-for-Tat: Type VI Secretion System Counterattack during Bacterial Cell-Cell Interactions. Cell. 152(4):884-94. [PudMed:23415234] [4] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagL | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| ACIAD_RS12160 | 2628937..2629467 | - | 531 | WP_026056971.1 | flavin reductase family protein | ||
| ACIAD_RS12165 | 2629502..2630740 | - | 1239 | WP_004928964.1 | hypothetical protein | ||
| ACIAD_RS12170 | 2630795..2631586 | - | 792 | WP_004928967.1 | SDR family oxidoreductase | ||
| ACIAD_RS12175 | 2631616..2632863 | - | 1248 | WP_004928970.1 | dienelactone hydrolase family protein | ||
| ACIAD_RS12180 | 2633143..2634144 | - | 1002 | WP_004928972.1 | AraC family transcriptional regulator | ||
| ACIAD_RS12185 | 2634401..2635675 | - | 1275 | WP_171056930.1 | Glu/Leu/Phe/Val dehydrogenase | ||
| T6CP011380 | PAAR | ACIAD_RS12190 | 2635901..2636167 | - | 267 | WP_004928977.1 | PAAR domain-containing protein |
| T6CP011379 | TagL | ACIAD_RS12195 | 2636197..2636961 | - | 765 | WP_004928979.1 | OmpA family protein |
| ACIAD_RS12200 (tagF) | 2636964..2637923 | - | 960 | WP_004928987.1 | type VI secretion system-associated protein TagF | ||
| T6CP000520 | TssM | ACIAD_RS12205 (tssM) | 2637964..2641785 | - | 3822 | WP_004928993.1 | type VI secretion system membrane subunit TssM |
| ACIAD_RS12210 | 2641820..2643223 | - | 1404 | WP_004928997.1 | hypothetical protein | ||
| T6CP000521 | TssG | ACIAD_RS12215 (tssG) | 2643220..2644218 | - | 999 | WP_004928999.1 | type VI secretion system baseplate subunit TssG |
| T6CP000522 | TssF | ACIAD_RS12220 (tssF) | 2644182..2645990 | - | 1809 | WP_004929001.1 | type VI secretion system baseplate subunit TssF |
| T6CP000523 | TssE | ACIAD_RS12225 (tssE) | 2646002..2646475 | - | 474 | WP_004929004.1 | type VI secretion system baseplate subunit TssE |
| T6CP000524 | TssD | ACIAD_RS12230 | 2646545..2647048 | - | 504 | WP_004929007.1 | type VI secretion system tube protein Hcp |
| T6CP000525 | TssC | ACIAD_RS12235 (tssC) | 2647094..2648575 | - | 1482 | WP_004929011.1 | type VI secretion system contractile sheath large subunit |
| T6CP000526 | TssB | ACIAD_RS12240 (tssB) | 2648568..2649071 | - | 504 | WP_004929014.1 | type VI secretion system contractile sheath small subunit |
| ACIAD_RS12245 | 2649091..2649747 | - | 657 | WP_004929016.1 | hypothetical protein | ||
| T6CP000527 | TssH | ACIAD_RS12250 (tssH) | 2650134..2652809 | + | 2676 | WP_100222860.1 | type VI secretion system ATPase TssH |
| T6CP000528 | TssA | ACIAD_RS12255 (tssA) | 2652825..2653928 | + | 1104 | WP_004929021.1 | type VI secretion system protein TssA |
| T6CP000529 | TssK | ACIAD_RS12260 (tssK) | 2653945..2655312 | + | 1368 | WP_004929024.1 | type VI secretion system baseplate subunit TssK |
| T6CP000530 | TssL | ACIAD_RS12265 | 2655324..2656127 | + | 804 | WP_004929028.1 | type IVB secretion system protein IcmH/DotU |
| ACIAD_RS12270 | 2656138..2656719 | + | 582 | WP_004929031.1 | hypothetical protein | ||
| ACIAD_RS12275 | 2656730..2657683 | + | 954 | WP_026056969.1 | M15 family metallopeptidase | ||
| ACIAD_RS12280 (prpF) | 2657701..2658882 | - | 1182 | WP_004929035.1 | 2-methylaconitate cis-trans isomerase PrpF | ||
| ACIAD_RS12285 | 2659669..2660025 | + | 357 | WP_004929038.1 | hypothetical protein | ||
| ACIAD_RS12290 | 2660030..2660530 | + | 501 | WP_004929041.1 | hypothetical protein | ||
| ACIAD_RS12295 | 2660893..2661510 | + | 618 | WP_004929047.1 | hypothetical protein | ||
| ACIAD_RS12300 | 2661512..2661904 | + | 393 | WP_004929049.1 | hypothetical protein | ||
| ACIAD_RS12305 | 2662359..2663201 | + | 843 | WP_004929052.1 | hypothetical protein | ||
| ACIAD_RS12310 | 2663226..2663423 | + | 198 | WP_011182593.1 | hypothetical protein | ||
| ACIAD_RS12315 | 2663658..2664314 | + | 657 | WP_004929058.1 | hypothetical protein | ||
| ACIAD_RS12325 | 2664856..2665167 | + | 312 | WP_004929065.1 | hypothetical protein | ||
| ACIAD_RS12330 | 2665176..2665442 | + | 267 | WP_011182594.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed. Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00293 |
ACIAD0054 (Tpi1) | EFF01469 |
Acinetobacter baylyi ADP1 | chromosome (NC_005966) | 56618..57070 (+) | 50083348 |
| IMU00294 |
ACIAD0169 (Tai1) | EFF01470 |
Acinetobacter baylyi ADP1 | chromosome (NC_005966) | 172382..173107 (+) | 50083454 |
| IMU00295 |
ACIAD3426 (Tli1) | EFF01472 |
Acinetobacter baylyi ADP1 | chromosome (NC_005966) | 3341328..3342386 (-) | 50086394 |
| IMU00296 |
ACIAD3112 (Tsi2a) | EFF01471 |
Acinetobacter baylyi ADP1 | chromosome (NC_005966) | 3038267..3039250 (+) | 50086116 |
| IMU00297 |
ACIAD3113 (Tsi2b) | EFF01471 |
Acinetobacter baylyi ADP1 | chromosome (NC_005966) | 3039389..3040372 (+) | 50086117 |
| IMU00298 |
ACIAD1796 (Tsi1b) | EFF01801 |
Acinetobacter baylyi ADP1 | chromosome (NC_005966) | 1803547..1804635 (+) | 50084944 |
| IMU00299 |
ACIAD1795 (Tsi1a) | EFF01801 |
Acinetobacter baylyi ADP1 | chromosome (NC_005966) | 1802446..1803534 (+) | 50084943 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| ACP00017 |
ACIAD_RS12210 | chaperone | Acinetobacter baylyi ADP1 | chromosome (NC_005966) | 2641820..2643223 (-) | WP_004928997.1 | - | - |
| ACP00018 |
ACIAD_RS12275 | chaperone | Acinetobacter baylyi ADP1 | chromosome (NC_005966) | 2656730..2657683 (+) | WP_026056969.1 | - | peptidoglycan |