Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00260  |
| T6SS type | Type i3 |
| Strain | Yersinia pseudotuberculosis YPIII |
| Replicon (RefSeq) | chromosome (NC_010465) |
| Location | 3905709..3929297 |
| Function | effector translocation |
| Comment | T6SS has an unexpected function in H+ extrusion under acid conditions. |
| References | [1] Wang T et al (2015) Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity. PLoS Pathog. 11(7):e1005020. [PudMed:26134274] [2] Zhang W et al (2011) Modulation of a thermoregulated type VI secretion system by AHL-dependent quorum sensing in Yersinia pseudotuberculosis. Arch Microbiol. 193(5):351-63. [PudMed:21298257] [3] Zhang W et al (2012) A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ Microbiol. 15(2):557-69. [PudMed:23094603] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| YPK_RS17830 (rapA) | 3902173..3905079 | + | 2907 | WP_011191719.1 | RNA polymerase-associated protein RapA | ||
| YPK_RS17835 | 3905334..3905687 | - | 354 | WP_002210468.1 | hypothetical protein | ||
| YPK_RS17840 (tssM) | 3905709..3909150 | - | 3442 | pseudogene | type VI secretion system membrane subunit TssM | ||
| T6CP002565 | TssL | YPK_RS17845 | 3909212..3910822 | - | 1611 | WP_012304591.1 | type IVB secretion system protein IcmH/DotU |
| T6CP002566 | TssK | YPK_RS17850 (tssK) | 3910819..3912174 | - | 1356 | WP_002210470.1 | type VI secretion system baseplate subunit TssK |
| T6CP002567 | TssJ | YPK_RS17855 (tssJ) | 3912294..3912785 | - | 492 | WP_012304592.1 | type VI secretion system lipoprotein TssJ |
| T6CP011652 | PAAR | YPK_RS17860 | 3912778..3913143 | - | 366 | WP_002214737.1 | DUF4150 domain-containing protein |
| YPK_RS17865 | 3913149..3913766 | - | 618 | WP_002210473.1 | DUF3540 domain-containing protein | ||
| YPK_RS17870 | 3913759..3914862 | - | 1104 | WP_002214739.1 | pentapeptide repeat-containing protein | ||
| YPK_RS17875 | 3914888..3917107 | - | 2220 | WP_002224087.1 | pentapeptide repeat-containing protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
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Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01462 | YPK_RS17835 | Tie | - | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 3905334..3905687 (-) | 169752298 |
| EFF00321 | YPK_RS17880 | - | - | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 3917120..3919468 (-) | 170025773 |
| EFF00322 | YPK_RS17905 | - | - | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 3925548..3926066 (-) | 170025778 |
| EFF76649 | YPK_3548 (TssS) | Tie | - | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 3905041..3905187 (-) | - |
Showing 1 to 4 of 4 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00376 | YPK_0955 (Tci1) | EFF01874 | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 1070252..1070536 (+) | 499506273 |
Showing 1 to 1 of 1 rows
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||