Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00260  |
| T6SS type | Type i3 |
| Strain | Yersinia pseudotuberculosis YPIII |
| Replicon (RefSeq) | chromosome (NC_010465) |
| Location | 3905709..3929297 |
| Function | effector translocation |
| Comment | T6SS has an unexpected function in H+ extrusion under acid conditions. |
| References | [1] Wang T et al (2015) Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity. PLoS Pathog. 11(7):e1005020. [PudMed:26134274] [2] Zhang W et al (2011) Modulation of a thermoregulated type VI secretion system by AHL-dependent quorum sensing in Yersinia pseudotuberculosis. Arch Microbiol. 193(5):351-63. [PudMed:21298257] [3] Zhang W et al (2012) A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ Microbiol. 15(2):557-69. [PudMed:23094603] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| YPK_RS17830 (rapA) | 3902173..3905079 | + | 2907 | WP_011191719.1 | RNA polymerase-associated protein RapA | ||
| YPK_RS17835 | 3905334..3905687 | - | 354 | WP_002210468.1 | hypothetical protein | ||
| YPK_RS17840 (tssM) | 3905709..3909150 | - | 3442 | pseudogene | type VI secretion system membrane subunit TssM | ||
| T6CP002565 | TssL | YPK_RS17845 | 3909212..3910822 | - | 1611 | WP_012304591.1 | type IVB secretion system protein IcmH/DotU |
| T6CP002566 | TssK | YPK_RS17850 (tssK) | 3910819..3912174 | - | 1356 | WP_002210470.1 | type VI secretion system baseplate subunit TssK |
| T6CP002567 | TssJ | YPK_RS17855 (tssJ) | 3912294..3912785 | - | 492 | WP_012304592.1 | type VI secretion system lipoprotein TssJ |
| T6CP011652 | PAAR | YPK_RS17860 | 3912778..3913143 | - | 366 | WP_002214737.1 | DUF4150 domain-containing protein |
| YPK_RS17865 | 3913149..3913766 | - | 618 | WP_002210473.1 | DUF3540 domain-containing protein | ||
| YPK_RS17870 | 3913759..3914862 | - | 1104 | WP_002214739.1 | pentapeptide repeat-containing protein | ||
| YPK_RS17875 | 3914888..3917107 | - | 2220 | WP_002224087.1 | pentapeptide repeat-containing protein | ||
| T6CP002568 | TssI | YPK_RS17880 (vgrG) | 3917120..3919468 | - | 2349 | WP_011191715.1 | type VI secretion system tip protein VgrG |
| T6CP002569 | TssH | YPK_RS17885 (tssH) | 3919572..3922160 | - | 2589 | WP_002210475.1 | type VI secretion system ATPase TssH |
| T6CP002570 | TssG | YPK_RS17890 (tssG) | 3922178..3923161 | - | 984 | WP_012304593.1 | type VI secretion system baseplate subunit TssG |
| T6CP002571 | TssF | YPK_RS17895 (tssF) | 3923154..3924998 | - | 1845 | WP_012304594.1 | type VI secretion system baseplate subunit TssF |
| T6CP002572 | TssE | YPK_RS17900 | 3925031..3925474 | - | 444 | WP_002210478.1 | type VI secretion system baseplate subunit TssE |
| T6CP002573 | TssD | YPK_RS17905 | 3925548..3926066 | - | 519 | WP_012304595.1 | type VI secretion system tube protein Hcp |
| T6CP002574 | TssC | YPK_RS17910 (tssC) | 3926229..3927731 | - | 1503 | WP_002210480.1 | type VI secretion system contractile sheath large subunit |
| T6CP002575 | TssB | YPK_RS17915 (tssB) | 3927740..3928300 | - | 561 | WP_002210481.1 | type VI secretion system contractile sheath small subunit |
| T6CP002576 | TssA | YPK_RS17920 | 3928311..3929324 | - | 1014 | WP_002210482.1 | ImpA family type VI secretion system protein |
| YPK_RS17925 | 3929654..3930397 | + | 744 | WP_002214747.1 | hexameric transcriptional regulator RovC | ||
| YPK_RS17930 (rluA) | 3931620..3932240 | + | 621 | WP_002210485.1 | bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA | ||
| YPK_RS17935 (djlA) | 3932557..3933390 | - | 834 | WP_012304596.1 | co-chaperone DjlA |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed. Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01462 |
YPK_RS17835 | Tie | - | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 3905334..3905687 (-) | 169752298 |
| EFF00321 |
YPK_RS17880 | - | - | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 3917120..3919468 (-) | 170025773 |
| EFF00322 |
YPK_RS17905 | - | - | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 3925548..3926066 (-) | 170025778 |
| EFF76649 |
YPK_3548 (TssS) | Tie | - | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 3905041..3905187 (-) | - |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00376 |
YPK_0955 (Tci1) | EFF01874 |
Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 1070252..1070536 (+) | 499506273 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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