Detailed information of effector
|Cognate immunity protein||-|
|Related T6SS (Type)||T6SS00260 (Type i3)|
|Strain||Yersinia pseudotuberculosis YPIII|
|Sequence||Protein sequence (49 a.a.); Nucleotide sequence (147 bp)|
|Description||TssS is a Mn2+-chelating protein and that its Mn2+-chelating ability is essential for the disruption of host innate immunity. TssS counteracted the cytoplasmic Mn2+ increase to inhibit the STING-mediated innate immune response by sequesteing Mn2+. TssS-mediated STING inhibition sabotaged bacterial clearance in vivo.|
Bioinformatics investigation has been performed
External database links
|Locus tag (Gene)||YPK_3548 (TssS)|
|Coordinates (Strand)||3905041..3905187 (-)|
Pfam domain hit(s)
|Domain||Pfam ID||E-value||Aligned region|
- Transmembrane helices are predicted using TMHMM 2.0 software.
- Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
- Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
- Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
|Prediction||Probability||Cleavage site||Signal peptide sequence|
Protein sequence: 49 a.a. .
Nucleotide sequence: 147 bp .