Detailed information of regulator
Summary
| Regulator ID | REG0191  |
| Regulator type | protein |
| Regulatory pathway (from literatures) | (p)ppGpp regulatory pathway |
| KEGG pathway (determined by BlastKOALA) | Metabolic pathways (map01100); Microbial metabolism in diverse environments (map01120); Carbon metabolism (map01200); Pyruvate metabolism (map00620); Propanoate metabolism (map00640); Carbon fixation pathways in prokaryotes (map00720); Methane metabolism (map00680); Taurine and hypotaurine metabolism (map00430) |
| Related T6SS | T6SS00260 (Type i3) |
| Strain | Yersinia pseudotuberculosis YPIII |
| Replicon | chromosome |
| Sequence | Protein sequence (401 a.a.); Nucleotide sequence (1203 bp) |
| Description | RovM upregulates T6SS4 by binding directly to the T6SS4 promoter, even also suppressing the expression of RovA. |
| Reference |
External database links
| Locus tag (Gene) | YPK_1551 (RovM) |
| Coordinates (Strand) | 1713682..1714884 (-) |
| NCBI ID | 499506038 |
| RefSeq | NC_010465 |
| Uniprot ID | ACKA_YERPS, ACKA_YERPY |
| KEGG ID | ypo:BZ17_4042, ypy:YPK_1551, yps:YPTB2597 |
| KEGG pathway (determined by BlastKOALA) | map01100; map01120; map01200; map00620; map00640; map00720; map00680; map00430 |
| PDB ID | - |
Target
| Target | Regulation (↓/↑) | Target sequence |
|---|---|---|
| T6SS-4 promoter region | ↓ | TGCTAATGGTTATGTAAATTTAATAAATGTA |
Pfam domain hit(s) of regulator
| Domain | Pfam ID | E-value | Aligned region |
|---|---|---|---|
| Acetate_kinase | PF00871.19 | 2e-184 | 5..393 |
Transmembrane helices
- Transmembrane helices are predicted using TMHMM 2.0 software.
| Prediction | Region | Sequence |
|---|---|---|
| Outside | 1-400 | MSSKLVLVLNCGSSSLKFAIIDATNGEEHISGLAECFHLPEARIKWKVDGGKQEAALGAGAAHSEALNFIVNTILAQKPALSAQLTAIGHRIVHGGEKFTSSVIVTDDVIQGIKDSIPFAPLHNPAHLIGIAEALKSFPNLADKNVAVFDTAFHQTMPEESYLYALPYSLYKDHGIRRYGAHGTSHFYVSQEAAKILNKPLEELNVITCHLGNGGSVTAVRNGKCVDTSMGLTPLEGLVMGTRSGDLDPAIIFHLHDAMGMSVDQINTLLTKESGLLGLTEVTSDCRYVEDNYATKADAKRAMDVFCHRLAKYIGSYTALMDGRLDAVVFTGGIGENAAMVRELTLDKLGLLGFEIDHERNMAARFGKSGTITKDSSRLALVIPTNEELVIAQDAARLTA |
Signal peptides
- Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
- Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
- Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
| Prediction | Probability | Cleavage site | Signal peptide sequence |
|---|---|---|---|
| Other | 0.8038 | - | - |
Protein sequence of regulator: 401 a.a. .
>REG0191 NC_010465:c1714884-1713682 [Yersinia pseudotuberculosis YPIII]
MSSKLVLVLNCGSSSLKFAIIDATNGEEHISGLAECFHLPEARIKWKVDGGKQEAALGAGAAHSEALNFIVNTILAQKPA
LSAQLTAIGHRIVHGGEKFTSSVIVTDDVIQGIKDSIPFAPLHNPAHLIGIAEALKSFPNLADKNVAVFDTAFHQTMPEE
SYLYALPYSLYKDHGIRRYGAHGTSHFYVSQEAAKILNKPLEELNVITCHLGNGGSVTAVRNGKCVDTSMGLTPLEGLVM
GTRSGDLDPAIIFHLHDAMGMSVDQINTLLTKESGLLGLTEVTSDCRYVEDNYATKADAKRAMDVFCHRLAKYIGSYTAL
MDGRLDAVVFTGGIGENAAMVRELTLDKLGLLGFEIDHERNMAARFGKSGTITKDSSRLALVIPTNEELVIAQDAARLTA
*
MSSKLVLVLNCGSSSLKFAIIDATNGEEHISGLAECFHLPEARIKWKVDGGKQEAALGAGAAHSEALNFIVNTILAQKPA
LSAQLTAIGHRIVHGGEKFTSSVIVTDDVIQGIKDSIPFAPLHNPAHLIGIAEALKSFPNLADKNVAVFDTAFHQTMPEE
SYLYALPYSLYKDHGIRRYGAHGTSHFYVSQEAAKILNKPLEELNVITCHLGNGGSVTAVRNGKCVDTSMGLTPLEGLVM
GTRSGDLDPAIIFHLHDAMGMSVDQINTLLTKESGLLGLTEVTSDCRYVEDNYATKADAKRAMDVFCHRLAKYIGSYTAL
MDGRLDAVVFTGGIGENAAMVRELTLDKLGLLGFEIDHERNMAARFGKSGTITKDSSRLALVIPTNEELVIAQDAARLTA
*
Nucleotide sequence of regulator: 1203 bp .
>REG0191 NC_010465:c1714884-1713682 [Yersinia pseudotuberculosis YPIII]
ATGTCGAGTAAGCTAGTACTGGTTCTTAACTGCGGTAGCTCCTCCCTGAAATTTGCAATCATCGATGCGACCAACGGTGA
AGAGCATATTTCTGGTTTAGCCGAATGTTTCCATCTGCCAGAAGCCCGTATCAAATGGAAAGTTGACGGCGGTAAGCAGG
AAGCAGCATTGGGTGCTGGTGCAGCACACAGCGAAGCACTGAATTTTATTGTTAATACTATTTTGGCACAAAAACCAGCG
CTTTCTGCTCAGTTGACGGCCATCGGTCACCGTATCGTTCACGGCGGCGAGAAATTCACTTCGTCAGTTATCGTTACCGA
CGATGTTATTCAGGGTATCAAAGATTCTATCCCGTTTGCACCACTACACAACCCTGCCCACTTGATCGGTATTGCTGAAG
CCTTGAAATCCTTCCCTAATCTGGCGGATAAAAATGTGGCCGTCTTTGACACCGCGTTCCATCAGACCATGCCGGAAGAG
TCTTATCTCTATGCTCTGCCGTACAGCCTGTATAAAGATCACGGTATCCGCCGCTATGGCGCACACGGTACCAGCCACTT
CTATGTTAGCCAAGAAGCCGCCAAGATCTTGAACAAGCCGTTGGAAGAACTGAACGTGATTACCTGCCATTTGGGCAACG
GTGGTTCAGTAACCGCAGTGCGTAACGGTAAATGTGTCGATACGTCAATGGGGCTAACGCCACTGGAAGGTCTGGTGATG
GGGACCCGCAGTGGTGATCTCGATCCCGCTATTATCTTCCATCTGCATGATGCTATGGGCATGAGCGTTGATCAAATCAA
CACGTTGCTGACCAAAGAGTCAGGCCTGTTGGGGCTGACTGAAGTCACCAGCGACTGCCGTTATGTTGAAGATAACTACG
CCACCAAAGCTGACGCGAAACGTGCGATGGATGTGTTCTGTCACCGTTTGGCAAAATATATCGGTTCCTATACCGCGCTG
ATGGATGGTCGTCTGGATGCGGTCGTCTTCACCGGTGGTATTGGTGAAAATGCTGCCATGGTCCGTGAACTGACGCTGGA
CAAATTGGGCCTGCTGGGCTTTGAGATTGACCACGAACGTAACATGGCAGCACGCTTTGGCAAGTCAGGTACCATCACCA
AAGATAGCAGCCGTCTGGCTCTGGTTATCCCAACCAACGAAGAGTTGGTTATCGCGCAAGACGCAGCCCGTCTGACTGCG
TAA
ATGTCGAGTAAGCTAGTACTGGTTCTTAACTGCGGTAGCTCCTCCCTGAAATTTGCAATCATCGATGCGACCAACGGTGA
AGAGCATATTTCTGGTTTAGCCGAATGTTTCCATCTGCCAGAAGCCCGTATCAAATGGAAAGTTGACGGCGGTAAGCAGG
AAGCAGCATTGGGTGCTGGTGCAGCACACAGCGAAGCACTGAATTTTATTGTTAATACTATTTTGGCACAAAAACCAGCG
CTTTCTGCTCAGTTGACGGCCATCGGTCACCGTATCGTTCACGGCGGCGAGAAATTCACTTCGTCAGTTATCGTTACCGA
CGATGTTATTCAGGGTATCAAAGATTCTATCCCGTTTGCACCACTACACAACCCTGCCCACTTGATCGGTATTGCTGAAG
CCTTGAAATCCTTCCCTAATCTGGCGGATAAAAATGTGGCCGTCTTTGACACCGCGTTCCATCAGACCATGCCGGAAGAG
TCTTATCTCTATGCTCTGCCGTACAGCCTGTATAAAGATCACGGTATCCGCCGCTATGGCGCACACGGTACCAGCCACTT
CTATGTTAGCCAAGAAGCCGCCAAGATCTTGAACAAGCCGTTGGAAGAACTGAACGTGATTACCTGCCATTTGGGCAACG
GTGGTTCAGTAACCGCAGTGCGTAACGGTAAATGTGTCGATACGTCAATGGGGCTAACGCCACTGGAAGGTCTGGTGATG
GGGACCCGCAGTGGTGATCTCGATCCCGCTATTATCTTCCATCTGCATGATGCTATGGGCATGAGCGTTGATCAAATCAA
CACGTTGCTGACCAAAGAGTCAGGCCTGTTGGGGCTGACTGAAGTCACCAGCGACTGCCGTTATGTTGAAGATAACTACG
CCACCAAAGCTGACGCGAAACGTGCGATGGATGTGTTCTGTCACCGTTTGGCAAAATATATCGGTTCCTATACCGCGCTG
ATGGATGGTCGTCTGGATGCGGTCGTCTTCACCGGTGGTATTGGTGAAAATGCTGCCATGGTCCGTGAACTGACGCTGGA
CAAATTGGGCCTGCTGGGCTTTGAGATTGACCACGAACGTAACATGGCAGCACGCTTTGGCAAGTCAGGTACCATCACCA
AAGATAGCAGCCGTCTGGCTCTGGTTATCCCAACCAACGAAGAGTTGGTTATCGCGCAAGACGCAGCCCGTCTGACTGCG
TAA