SecReT6, T6SS database

Detailed information of effector

Summary

Effector ID	EFF01462
Effector type	Tie
Cognate immunity protein	-
Related T6SS (Type)	T6SS00260 (Type i3)
Strain	Yersinia pseudotuberculosis YPIII
Replicon	chromosome
Sequence	Protein sequence (118 a.a.); Nucleotide sequence (354 bp)
Description	Zn2+-binding protein substrate YezP has the capacity to rescue the sensitivity to oxidative stress exhibited by T6SS-4 mutants when added to extracellular milieu.
Reference	[1] Wang T, Si M, Song Y, et al. Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity. PLoS Pathog. 2015 Jul 2;11(7):e1005020. doi: 10.1371/journal.ppat.1005020. eCollection 2015 Jul. PMID: 26134274

Experimental investigation has been performed.

Bioinformatics investigation has been performed

External database links

Locus tag (Gene)	YPK_RS17835
Coordinates (Strand)	3905334..3905687 (-)
NCBI ID	169752298
RefSeq	NC_010465
Uniprot ID	A0A0H3B7J5_YERPY
KEGG ID	ypy:YPK_3549
PDB ID	-

Pfam domain hit(s)

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Domain	Pfam ID	E-value	Aligned region
DUF6277	PF19793.1	2.8e-53	1..117

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Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction	Region	Sequence
Outside	1-117	MLDPKNIQNVLKSSTDLGQQSQSDLQKPFVKGMQNMEMSGADAARSIMQSVNQSCETMMSDMNKILGGLQDNVDAHQKMQSEERPKDFERAMSDLRSTLSNGFPEEMKSMFDKLPKM

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

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Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9656	-	-

Protein sequence: 118 a.a. .

                                    >EFF01462 NC_010465:c3905687-3905334 Type VI Metal Ion acquisition Effector (Tie) [Yersinia pseudotuberculosis YPIII]
MLDPKNIQNVLKSSTDLGQQSQSDLQKPFVKGMQNMEMSGADAARSIMQSVNQSCETMMSDMNKILGGLQDNVDAHQKMQ
SEERPKDFERAMSDLRSTLSNGFPEEMKSMFDKLPKM*

                                

Nucleotide sequence: 354 bp .

                                    >EFF01462 NC_010465:c3905687-3905334 Type VI Metal Ion acquisition Effector (Tie) [Yersinia pseudotuberculosis YPIII]
ATGCTAGATCCTAAAAACATCCAGAATGTATTGAAGTCATCTACTGACCTTGGTCAGCAATCTCAATCTGATTTGCAGAA
ACCTTTTGTAAAAGGAATGCAAAATATGGAGATGTCAGGGGCCGATGCCGCTCGCAGTATCATGCAATCGGTTAATCAAT
CCTGCGAAACCATGATGAGCGATATGAATAAGATATTGGGAGGATTGCAGGACAATGTTGATGCTCACCAGAAAATGCAA
AGTGAGGAGCGTCCGAAGGACTTCGAGAGAGCCATGAGTGATCTTCGCAGCACACTCTCCAATGGTTTCCCAGAGGAAAT
GAAAAGTATGTTTGATAAATTGCCCAAAATGTAG

                                