Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
T6SS ID | T6SS00158 ![]() |
T6SS type | Type ii |
Strain | Francisella tularensis subsp. novicida U112 |
Replicon (RefSeq) | chromosome (NC_008601) |
Location | 1378294..1404786 |
Function | anti-eukaryotic; effector translocation; virulence |
Comment | Intracellular growth in cultured murine macrophages. |
References | [1] Nano FE et al (2007) The Francisella pathogenicity island. Ann N Y Acad Sci. 1105:122-37. [PudMed:17395722] [2] Broms JE et al (2012) Unique Substrates Secreted by the Type VI Secretion System of Francisella tularensis during Intramacrophage Infection. PLoS One. 7(11):e50473. [PudMed:23185631] [3] Barker JR et al (2009) The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence. Mol Microbiol. 74(6):1459-70. [PudMed:20054881] [4] Hare RF et al (2014) Francisella novicida Pathogenicity Island Encoded Proteins Were Secreted during Infection of Macrophage-Like Cells. PLoS One. 9(8):e105773. [PudMed:25158041] [5] de Bruin OM et al (2011) The biochemical properties of the Francisella pathogenicity island (FPI)-encoded proteins IglA, IglB, IglC, PdpB and DotU suggest roles in type VI secretion. Microbiology. 157(Pt 12):3483-91. [PudMed:21980115] [6] Robb CS et al (2010) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of intracellular growth locus E (IglE) protein from Francisella tularensis subsp. novicida. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66(Pt 12):1596-8. [PudMed:21139203] |

T6SS components and genome coordinates
Component | ClpB | IglC | IglD | IglE | IglF | IglG | IglH | IglI | IglJ | PdpA | PdpB | PdpC | PdpD | PdpE | TssB | TssC | TssI | TssL |
Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |

Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
---|---|---|---|---|---|---|---|
T6CP004914 | PdpA | FTN_RS06705 | 1378294..1380756 | + | 2463 | WP_003040109.1 | hypothetical protein |
T6CP004915 | PdpB | FTN_RS06710 | 1380761..1384042 | + | 3282 | WP_003040112.1 | hypothetical protein |
T6CP004916 | IglE | FTN_RS06715 | 1384032..1384409 | + | 378 | WP_003040115.1 | hypothetical protein |
T6CP004917 | TssI | FTN_RS06720 | 1384422..1384916 | + | 495 | WP_003037116.1 | hypothetical protein |
T6CP004918 | IglF | FTN_RS06725 | 1384921..1386651 | + | 1731 | WP_003040118.1 | hypothetical protein |
T6CP004919 | IglG | FTN_RS06730 | 1386652..1387173 | + | 522 | WP_003040120.1 | DUF4280 domain-containing protein |
T6CP004920 | IglH | FTN_RS06735 | 1387186..1388616 | + | 1431 | WP_003040123.1 | hypothetical protein |
T6CP004921 | TssL | FTN_RS06740 | 1388629..1389252 | + | 624 | WP_003040125.1 | DotU family type IV/VI secretion system protein |
T6CP004922 | IglI | FTN_RS06745 | 1389274..1390425 | + | 1152 | WP_003040128.1 | hypothetical protein |
T6CP004923 | IglJ | FTN_RS06750 | 1390391..1391164 | + | 774 | WP_011733698.1 | hypothetical protein |
T6CP004924 | PdpC | FTN_RS06755 (pdpC) | 1391204..1395181 | + | 3978 | WP_003040134.1 | pathogenicity determinant protein PdpC |
T6CP004925 | PdpE | FTN_RS06760 | 1395199..1395765 | + | 567 | WP_003040137.1 | hypothetical protein |
T6CP004926 | IglD | FTN_RS06765 | 1395772..1396968 | - | 1197 | WP_003040140.1 | hypothetical protein |
T6CP004927 | IglC | FTN_RS06770 | 1396989..1397618 | - | 630 | WP_003016165.1 | hypothetical protein |
T6CP004928 | TssC | FTN_RS06775 (tssC) | 1397635..1399155 | - | 1521 | WP_003040143.1 | type VI secretion system contractile sheath large subunit |
T6CP004929 | TssB | FTN_RS06780 (tssB) | 1399169..1399723 | - | 555 | WP_003040146.1 | type VI secretion system contractile sheath small subunit |
T6CP004930 | PdpD | FTN_RS06785 | 1399803..1403540 | - | 3738 | WP_003040148.1 | hypothetical protein |
FTN_RS06790 | 1403641..1404786 | - | 1146 | WP_011733699.1 | anhydro-N-acetylmuramic acid kinase | ||
FTN_RS06795 | 1404933..1406117 | + | 1185 | pseudogene | MFS transporter | ||
FTN_RS06800 | 1406119..1407573 | + | 1455 | WP_011733700.1 | alpha,alpha-trehalase | ||
FTN_RS06805 | 1407740..1408804 | - | 1065 | WP_003034542.1 | fructose-bisphosphate aldolase class II |
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.






Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
---|---|---|---|---|---|---|---|---|
ACP00023 ![]() |
FTN_RS06580 (dnaK) | chaperone | Francisella tularensis subsp. novicida U112 | chromosome (NC_008601) | 1356202..1358130 (-) | 489130276 | FTN_RS08950 (ClpB) | - |