Detailed information of regulator
Summary
| Regulator ID | REG0178  |
| Regulator type | protein |
| Regulatory pathway (from literatures) | TCS regulatory pathway |
| KEGG pathway (determined by BlastKOALA) | - |
| Related T6SS | T6SS00158 (Type ii) |
| Strain | Francisella tularensis subsp. novicida U112 |
| Replicon | chromosome |
| Sequence | Protein sequence (112 a.a.); Nucleotide sequence (336 bp) |
| Description | MglA positively regulates the expression of fevR and, MglA and FevR are both required to initiate transcription of the genes in the MglA/SspA regulon including T6SS operon. |
| Reference |
External database links
| Locus tag (Gene) | FTN_0480 (fevR/PigR) |
| Coordinates (Strand) | 486541..486876 (+) |
| NCBI ID | 489108070 |
| RefSeq | NC_008601 |
| Uniprot ID | A0A153JBB2_9GAMM, A0A0B3VR08_FRATU, A0A1J0KLY4_FRANO, A0Q561_FRATN, A0A1S2WUJ7_9GAMM, F4BJE8_9GAMM |
| KEGG ID | ftn:FTN_0480, ftc:DA46_245, fcn:FN3523_0435, ftv:CH67_751, fty:CH70_1583, ftz:CH68_485, ftx:AW25_1548, fhi:FSC454_02210 |
| KEGG pathway (determined by BlastKOALA) | - |
| PDB ID | - |
Target
| Target | Regulation (↓/↑) | Target sequence |
|---|---|---|
| T6SS Transciption | ↓ | - |
Pfam domain hit(s) of regulator
| Domain | Pfam ID | E-value | Aligned region |
|---|
Transmembrane helices
- Transmembrane helices are predicted using TMHMM 2.0 software.
| Prediction | Region | Sequence |
|---|---|---|
| Outside | 1-111 | MANQYSGNFEQIVKNRFKCSAREILLKCQREGLSYQDAEKVLGFKHVTIRKWAKRFDIKLPPRFRSHDEHLEQKREIAYVNQCKLNKINKRNVFSRCWINMNLYSVIKAKS |
Signal peptides
- Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
- Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
- Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
| Prediction | Probability | Cleavage site | Signal peptide sequence |
|---|---|---|---|
| Other | 0.9967 | - | - |
Protein sequence of regulator: 112 a.a. .
>REG0178 NC_008601:486541-486876 [Francisella tularensis subsp. novicida U112]
MANQYSGNFEQIVKNRFKCSAREILLKCQREGLSYQDAEKVLGFKHVTIRKWAKRFDIKLPPRFRSHDEHLEQKREIAYV
NQCKLNKINKRNVFSRCWINMNLYSVIKAKS*
MANQYSGNFEQIVKNRFKCSAREILLKCQREGLSYQDAEKVLGFKHVTIRKWAKRFDIKLPPRFRSHDEHLEQKREIAYV
NQCKLNKINKRNVFSRCWINMNLYSVIKAKS*
Nucleotide sequence of regulator: 336 bp .
>REG0178 NC_008601:486541-486876 [Francisella tularensis subsp. novicida U112]
ATGGCGAATCAATATTCTGGAAATTTTGAGCAAATTGTCAAAAATAGATTTAAATGCTCAGCAAGAGAGATCTTATTAAA
ATGCCAAAGAGAAGGCTTAAGTTACCAAGATGCTGAAAAAGTTTTGGGTTTTAAGCATGTTACTATCAGAAAGTGGGCTA
AGAGATTTGATATTAAGCTCCCGCCTAGATTTAGATCTCATGATGAGCATCTTGAACAAAAAAGAGAGATAGCATATGTC
AATCAATGTAAGTTGAATAAAATCAATAAAAGAAATGTTTTTAGTCGCTGCTGGATAAATATGAATCTTTATTCTGTAAT
CAAAGCTAAATCTTGA
ATGGCGAATCAATATTCTGGAAATTTTGAGCAAATTGTCAAAAATAGATTTAAATGCTCAGCAAGAGAGATCTTATTAAA
ATGCCAAAGAGAAGGCTTAAGTTACCAAGATGCTGAAAAAGTTTTGGGTTTTAAGCATGTTACTATCAGAAAGTGGGCTA
AGAGATTTGATATTAAGCTCCCGCCTAGATTTAGATCTCATGATGAGCATCTTGAACAAAAAAGAGAGATAGCATATGTC
AATCAATGTAAGTTGAATAAAATCAATAAAAGAAATGTTTTTAGTCGCTGCTGGATAAATATGAATCTTTATTCTGTAAT
CAAAGCTAAATCTTGA