Detailed information of regulator


Summary

Regulator ID REG0175 experimental
Regulator type protein
Regulatory pathway (from literatures) TCS-HK
KEGG pathway (determined by BlastKOALA) Two-component system (map02020)
Related T6SS T6SS00158 experimental (Type ii)
Strain Francisella tularensis subsp. novicida U112
Replicon chromosome
Sequence Protein sequence (894 a.a.); Nucleotide sequence (2682 bp)
Description The histidine kinase KdpD is primarily responsible for phosphorylation of PmrA.
Reference
External database links

Locus tag (Gene) FTN_RS08805 (KdpD)
Coordinates (Strand) 1838601..1841282 (-)
NCBI ID 489131611
RefSeq NC_008601
Uniprot ID A0Q8K7_FRATN
KEGG ID ftx:AW25_273, ftn:FTN_1715
KEGG pathway (determined by BlastKOALA) map02020
PDB ID -
  Target
Target Regulation (↓/↑) Target sequence
FTN_1465 (pmrA) ↓ 489108239
Pfam domain hit(s) of regulator

Domain Pfam ID E-value Aligned region
KdpD PF02702.19 3.3e-83 21..230
HATPase_c PF02518.28 2e-21 777..889
HisKA PF00512.27 3.5e-11 667..732
DUF4118 PF13493.8 5.1e-11 406..503
Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Outside 1-412 MDNQQKVDALLNLANKSQESKKGKLKIFLGYAPGVGKSYAMLNNARALQKDNKDVVVGLLVSHGRADTQALLEGLEIMPLKKVNYRGRVFEELDIDAIKARKPDVVIVDELPHSNLPTSRNKKRYIDIEELLDEGISVYTAINIQHIASLSYEVTQLTQANVNEIVPNDFIQSADELVVVDVSPEELIKRLKQGKVYKSDAIDRALERYFQYTNLTILRDYTFRMAANHVGQDIQQYRKLYQHGSAIPTSPYVLVCCGYDEATPSLLRKGKLLATTLNARLIAVFVQKPNKVATKLNFGVIRRYKMLASSLGYNIDHILGDRLSDSILEYAKSIGATDLVIGKSIRPKWKDKLFGSVVYDIIRNNNNGMQVHIVSINKKEHKLQEQPRHSKIKTKGLIIDVIKSALIAAVSG
Transmembrane helix 413-435 VFIFFSLSIAGLVSQTLCFLMVL
Inside 436-441 AACAYR
Transmembrane helix 442-463 YGLIPSIISSLVGLFLYIYLYL
Outside 464-472 EPNFVFHIS
Transmembrane helix 473-495 SLAGIITFAFFMTIVIFSSHVIL
Inside 496-893 RTKRAFTLLKERENSISVLYRFTKMFNEKSLDKDLRSVFLHALEEYFKCDFVFLSVSDGELDSAAFPQHPNFNQKELAAAKWSFKYKDSCGKGTNTFAGLDWAVEPLVIENRVLGVIAIYLSSETAVERITTDSVILSSMLSHISHILLKRNLEKEEKKSLLLDEQRRLQKSMLSSVSHDLKTPLASIMGALSSIKSYKDSFNPEQQVEMLDLALTESKRLDSYIDNIIQMLKVDSGKLSLNIQNVNSNLFLTEIQETCARVYNKQKFRFIMPKEQFEIELDPVLFQQVILNLIDNAVKFTCDFEKEIIISLKRKKAAFCLFEVQDKGIGLRESDMEKIFTIFHRIEKRDSYTHGNGLGLAICKGIVTAHNGKIRVYSDGEGKGSVFKITLPLKSSTN


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9743 - -


  Protein sequence of regulator: 894 a.a.    .

>REG0175 NC_008601:c1841282-1838601 [Francisella tularensis subsp. novicida U112]
MDNQQKVDALLNLANKSQESKKGKLKIFLGYAPGVGKSYAMLNNARALQKDNKDVVVGLLVSHGRADTQALLEGLEIMPL
KKVNYRGRVFEELDIDAIKARKPDVVIVDELPHSNLPTSRNKKRYIDIEELLDEGISVYTAINIQHIASLSYEVTQLTQA
NVNEIVPNDFIQSADELVVVDVSPEELIKRLKQGKVYKSDAIDRALERYFQYTNLTILRDYTFRMAANHVGQDIQQYRKL
YQHGSAIPTSPYVLVCCGYDEATPSLLRKGKLLATTLNARLIAVFVQKPNKVATKLNFGVIRRYKMLASSLGYNIDHILG
DRLSDSILEYAKSIGATDLVIGKSIRPKWKDKLFGSVVYDIIRNNNNGMQVHIVSINKKEHKLQEQPRHSKIKTKGLIID
VIKSALIAAVSGVFIFFSLSIAGLVSQTLCFLMVLAACAYRYGLIPSIISSLVGLFLYIYLYLEPNFVFHISSLAGIITF
AFFMTIVIFSSHVILRTKRAFTLLKERENSISVLYRFTKMFNEKSLDKDLRSVFLHALEEYFKCDFVFLSVSDGELDSAA
FPQHPNFNQKELAAAKWSFKYKDSCGKGTNTFAGLDWAVEPLVIENRVLGVIAIYLSSETAVERITTDSVILSSMLSHIS
HILLKRNLEKEEKKSLLLDEQRRLQKSMLSSVSHDLKTPLASIMGALSSIKSYKDSFNPEQQVEMLDLALTESKRLDSYI
DNIIQMLKVDSGKLSLNIQNVNSNLFLTEIQETCARVYNKQKFRFIMPKEQFEIELDPVLFQQVILNLIDNAVKFTCDFE
KEIIISLKRKKAAFCLFEVQDKGIGLRESDMEKIFTIFHRIEKRDSYTHGNGLGLAICKGIVTAHNGKIRVYSDGEGKGS
VFKITLPLKSSTN*

  Nucleotide sequence of regulator: 2682 bp    .

>REG0175 NC_008601:c1841282-1838601 [Francisella tularensis subsp. novicida U112]
ATGGATAATCAACAAAAAGTAGATGCACTGCTAAACCTAGCTAATAAAAGCCAAGAATCTAAAAAAGGTAAATTAAAAAT
CTTTCTTGGCTATGCTCCTGGTGTCGGTAAGAGTTATGCGATGCTTAATAATGCTCGAGCTTTACAGAAAGATAATAAAG
ATGTTGTGGTTGGCTTACTTGTAAGTCATGGCAGAGCAGACACACAGGCATTACTAGAGGGGCTTGAGATTATGCCTCTT
AAAAAGGTAAATTATCGTGGTAGAGTGTTTGAAGAGCTAGATATAGATGCAATTAAAGCTAGAAAACCTGATGTTGTGAT
CGTTGATGAATTACCTCATTCGAATTTACCGACATCACGAAACAAAAAAAGGTATATCGATATTGAAGAACTTCTTGATG
AGGGCATCTCAGTTTATACGGCGATTAATATTCAACATATTGCTAGCTTATCTTATGAGGTTACACAGCTTACTCAAGCT
AATGTTAATGAAATTGTTCCAAATGATTTTATTCAATCAGCTGATGAGCTTGTTGTAGTTGATGTAAGTCCAGAGGAACT
GATTAAAAGACTTAAACAAGGTAAAGTATATAAAAGTGATGCAATAGATAGAGCATTAGAAAGATATTTTCAATATACAA
ATCTAACCATCCTCAGAGATTATACTTTTAGGATGGCTGCAAACCATGTCGGTCAAGATATTCAGCAGTATAGGAAGCTT
TACCAACATGGTAGTGCTATACCAACTTCACCATATGTACTAGTATGCTGTGGCTATGATGAGGCGACTCCAAGTTTATT
ACGTAAAGGGAAGCTCTTAGCAACGACTTTAAACGCAAGACTAATAGCAGTTTTTGTACAAAAACCTAATAAGGTCGCAA
CTAAACTTAATTTTGGTGTTATTAGACGTTATAAAATGCTGGCAAGCAGTCTTGGATATAATATTGATCATATACTTGGT
GATAGGCTTTCAGATAGTATATTAGAGTACGCAAAATCAATAGGTGCAACTGATTTAGTAATCGGTAAATCGATACGACC
AAAATGGAAAGATAAACTTTTTGGTTCTGTTGTCTACGATATTATCCGTAATAATAACAATGGTATGCAAGTACACATTG
TTTCGATAAATAAAAAAGAGCACAAGCTTCAGGAACAGCCACGTCATAGTAAAATTAAGACAAAAGGCTTGATTATTGAT
GTGATAAAATCAGCATTAATAGCAGCAGTATCAGGAGTATTTATCTTCTTTAGCCTTAGTATTGCAGGTTTAGTTTCACA
AACTCTATGTTTTTTGATGGTTTTAGCAGCATGTGCTTATAGATATGGATTAATACCATCGATAATATCTTCATTAGTTG
GGTTATTTTTGTATATCTATCTCTATTTAGAACCAAATTTTGTTTTTCATATTTCTAGTTTAGCAGGGATAATTACTTTT
GCTTTCTTTATGACTATAGTTATATTCTCTAGCCATGTGATTCTAAGAACTAAAAGAGCTTTTACACTTCTAAAAGAACG
AGAAAATAGTATTTCGGTATTATACCGCTTTACAAAAATGTTTAATGAAAAGAGTTTAGATAAAGATCTACGCTCGGTAT
TTTTACATGCTTTAGAAGAGTATTTCAAGTGTGACTTTGTTTTTTTAAGTGTTTCAGATGGTGAGCTTGATTCAGCAGCT
TTTCCGCAACACCCAAATTTTAATCAAAAAGAATTAGCAGCCGCTAAATGGAGTTTTAAGTATAAGGATAGCTGTGGTAA
AGGTACTAATACCTTTGCTGGTTTAGATTGGGCAGTAGAACCATTAGTGATAGAAAATCGAGTCCTAGGAGTAATAGCAA
TATATTTAAGTTCAGAAACAGCAGTAGAGCGCATAACTACAGATAGTGTCATTCTAAGTAGTATGCTTTCGCATATTTCA
CATATTCTTTTGAAAAGAAATCTTGAAAAAGAGGAGAAGAAATCCTTACTTCTTGATGAGCAAAGACGCCTACAAAAATC
GATGTTATCATCGGTTTCTCATGATCTTAAAACACCGTTGGCTTCTATAATGGGTGCATTAAGTAGTATTAAGTCATACA
AAGATTCATTTAATCCAGAACAGCAGGTTGAGATGTTAGATTTAGCGCTAACAGAGTCAAAAAGACTTGATAGTTACATT
GATAATATAATCCAAATGCTTAAGGTTGATTCAGGAAAGCTTTCATTAAATATTCAAAATGTTAATAGTAATCTTTTCCT
AACTGAAATACAAGAAACTTGCGCAAGAGTATATAATAAACAGAAGTTCAGGTTTATAATGCCTAAGGAGCAATTTGAAA
TTGAGCTTGATCCAGTTTTATTCCAACAGGTAATTCTCAATTTGATTGATAATGCTGTTAAGTTTACGTGTGATTTTGAA
AAAGAGATTATAATTTCTCTTAAGAGAAAGAAAGCGGCATTCTGTCTTTTTGAGGTTCAAGATAAGGGTATTGGCTTAAG
AGAATCAGATATGGAAAAAATATTTACAATATTCCATAGAATTGAAAAGAGAGATAGCTATACACATGGTAATGGTTTAG
GCTTAGCTATATGTAAGGGCATAGTGACAGCGCACAATGGTAAGATCAGGGTGTATAGTGATGGCGAGGGTAAAGGCAGT
GTTTTCAAAATTACATTACCTTTAAAATCAAGTACAAATTAG