Regulators of regulatory pathway: TCS-HK

All displayed regulators are experimentally validated.


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0003 experimental RT90_01105 (rcsC) T6SS01264 experimental protein TCS-HK Serratia marcescens strain RM66262 chromosome (JWLO01000001) 232638..235499 (+) 735006326 RT90_01115 (rcsB) (↑)
REG0045 experimental PA0610 (prtN) T6SS00003 experimental protein TCS-HK Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 672777..673091 (-) 15595807 PA0611 (prtR) (↑)
REG0084 experimental chvG T6SS00016 experimental protein TCS-HK Agrobacterium fabrum str. C58 chromosome (NC_003062) 34679..36469 (-) chvI (↓)
REG0100 experimental VP_RS12495 (barA) T6SS00043 experimental; T6SS00044 experimental protein TCS-HK Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2712492..2715290 (+) 491625032 Hcp expression and secretion (↓)
REG0128 experimental BMAA0745 (VirA) T6SS00070 experimental protein TCS-HK Burkholderia mallei ATCC 23344 chromosome (NC_006349) 762932..764776 (+) 490305845 Hcp1 (BMAA0742) expression (↓)
REG0130 experimental BMAA0745 (VirA) T6SS00070 experimental protein TCS-HK Burkholderia mallei ATCC 23344 chromosome (NC_006349) 763148..764776 (+) 53717365 BMAA0746 (VirG) (↓)
REG0138 experimental BPSS1494 (virG) T6SS00077 insolico protein TCS-HK; BsaN regulon Burkholderia pseudomallei K96243 chromosome (NC_006351) 2037977..2038714 (-) 490663798 BPSS1495 (virA) (↓)
REG0145 experimental BPSS1495 (virA) T6SS00077 insolico protein TCS-HK Burkholderia pseudomallei K96243 chromosome (NC_006351) 2038711..2040555 (-) 53722517 hcp1 expression (↓)
REG0150 experimental Psyr_3698 (gacS) T6SS00086 experimental protein TCS-HK Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 4385550..4388303 (+) 499587812 T6SS transcription (↓)
REG0175 experimental FTN_RS08805 (KdpD) T6SS00158 experimental protein TCS-HK Francisella tularensis subsp. novicida U112 chromosome (NC_008601) 1838601..1841282 (-) 489131611 FTN_1465 (pmrA) (↓)
REG0244 experimental ETAE_2059 (phoP) T6SS00372 experimental protein TCS-HK Edwardsiella tarda EIB202 chromosome (NC_013508) 2172565..2173239 (+) 502611910 ETAE_0886 (EsrB) (↓)
REG0318 experimental Y113_RS04835 (esrC) T6SS00791 experimental protein TCS-HK Edwardsiella tarda strain PPD130/91 chromosome (NZ_JACQ01000008) 20632..23367 (-) 1624663318 EvpQ protein level (↓)
REG0323 experimental GT391_RS16925 (phoP) T6SS01170 experimental protein TCS-HK Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 3795787..3796476 (-) 497961604 GT391_RS06470 (expR1) (↑)
REG0331 experimental Pchl3084_3491 (gacA) T6SS01266 insolico; T6SS01267 insolico protein TCS-HK Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 4134794..4135435 (-) 496335231 Pchl3084_5419 (rsmY)promotor (↓); Pchl3084_1190 (rsmZ)promotor (↓); Pchl3084_1189 (rpoS)transcript (↓)
REG0339 experimental BN49_RS12735 (phoP) T6SS01214 experimental protein TCS-HK Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 2325637..2326308 (-) 490252783 BN49_2224 (phoQ) (↓)
REG0357 experimental PPECC33_RS11180 (BaeS) T6SS01034 experimental protein TCS-HK Escherichia coli PCN033 chromosome (NZ_CP006632) 2271464..2272867 (+) 446597798 PPECC33_RS11185 (BaeR) (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0003 experimental RT90_01105 (rcsC) T6SS01264 experimental protein TCS-HK Serratia marcescens strain RM66262 chromosome (JWLO01000001) 232638..235499 (+) 735006326 RT90_01115 (rcsB) (↑)
REG0045 experimental PA0610 (prtN) T6SS00003 experimental protein TCS-HK Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 672777..673091 (-) 15595807 PA0611 (prtR) (↑)
REG0084 experimental chvG T6SS00016 experimental protein TCS-HK Agrobacterium fabrum str. C58 chromosome (NC_003062) 34679..36469 (-) chvI (↓)
REG0100 experimental VP_RS12495 (barA) T6SS00043 experimental; T6SS00044 experimental protein TCS-HK Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2712492..2715290 (+) 491625032 Hcp expression and secretion (↓)
REG0128 experimental BMAA0745 (VirA) T6SS00070 experimental protein TCS-HK Burkholderia mallei ATCC 23344 chromosome (NC_006349) 762932..764776 (+) 490305845 Hcp1 (BMAA0742) expression (↓)
REG0130 experimental BMAA0745 (VirA) T6SS00070 experimental protein TCS-HK Burkholderia mallei ATCC 23344 chromosome (NC_006349) 763148..764776 (+) 53717365 BMAA0746 (VirG) (↓)
REG0138 experimental BPSS1494 (virG) T6SS00077 insolico protein TCS-HK; BsaN regulon Burkholderia pseudomallei K96243 chromosome (NC_006351) 2037977..2038714 (-) 490663798 BPSS1495 (virA) (↓)
REG0145 experimental BPSS1495 (virA) T6SS00077 insolico protein TCS-HK Burkholderia pseudomallei K96243 chromosome (NC_006351) 2038711..2040555 (-) 53722517 hcp1 expression (↓)
REG0150 experimental Psyr_3698 (gacS) T6SS00086 experimental protein TCS-HK Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 4385550..4388303 (+) 499587812 T6SS transcription (↓)
REG0175 experimental FTN_RS08805 (KdpD) T6SS00158 experimental protein TCS-HK Francisella tularensis subsp. novicida U112 chromosome (NC_008601) 1838601..1841282 (-) 489131611 FTN_1465 (pmrA) (↓)
REG0244 experimental ETAE_2059 (phoP) T6SS00372 experimental protein TCS-HK Edwardsiella tarda EIB202 chromosome (NC_013508) 2172565..2173239 (+) 502611910 ETAE_0886 (EsrB) (↓)
REG0318 experimental Y113_RS04835 (esrC) T6SS00791 experimental protein TCS-HK Edwardsiella tarda strain PPD130/91 chromosome (NZ_JACQ01000008) 20632..23367 (-) 1624663318 EvpQ protein level (↓)
REG0323 experimental GT391_RS16925 (phoP) T6SS01170 experimental protein TCS-HK Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 3795787..3796476 (-) 497961604 GT391_RS06470 (expR1) (↑)
REG0331 experimental Pchl3084_3491 (gacA) T6SS01266 insolico; T6SS01267 insolico protein TCS-HK Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 4134794..4135435 (-) 496335231 Pchl3084_5419 (rsmY)promotor (↓); Pchl3084_1190 (rsmZ)promotor (↓); Pchl3084_1189 (rpoS)transcript (↓)
REG0339 experimental BN49_RS12735 (phoP) T6SS01214 experimental protein TCS-HK Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 2325637..2326308 (-) 490252783 BN49_2224 (phoQ) (↓)
REG0357 experimental PPECC33_RS11180 (BaeS) T6SS01034 experimental protein TCS-HK Escherichia coli PCN033 chromosome (NZ_CP006632) 2271464..2272867 (+) 446597798 PPECC33_RS11185 (BaeR) (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)