Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00044  |
| T6SS type | Type i5 |
| Strain | Vibrio parahaemolyticus RIMD 2210633 |
| Replicon (RefSeq) | chromosome II (NC_004605) |
| Location | 1074208..1108114 |
| Function | anti-eukaryotic; effector translocation; adherence |
| Comment | Adhesion to cultured cell monolayers. |
| References | [1] Yu Y et al (2012) VPA1045 and VPA1049 of Vibrio parahaemolyticus regulate translocation of Hcp2. Wei Sheng Wu Xue Bao. 52(8):954-61. [PudMed:23173431] [2] Yu Y et al (2015) VgrG2 of type VI secretion system 2 of Vibrio parahaemolyticus induces autophagy in macrophages. Front Microbiol. 0.366666667. [PudMed:25784905] [3] Ma L et al (2012) Expression of the Type VI Secretion System 1 Component Hcp1 Is Indirectly Repressed by OpaR in Vibrio parahaemolyticus. Scientific World Journal. 2012:982140. [PudMed:22924031] [4] Yu Y et al (2012) Putative type VI secretion systems of Vibrio parahaemolyticus contribute to adhesion to cultured cell monolayers. Arch Microbiol. 194(10):827-35. [PudMed:22535222] [5] Salomon D et al (2013) Vibrio parahaemolyticus Type VI Secretion System 1 Is Activated in Marine Conditions to Target Bacteria, and Is Differentially Regulated from System 2. PLoS One. 8(4):e61086. [PudMed:23613791] [6] Wang L et al (2013) Cell Density- and Quorum Sensing-Dependent Expression of Type VI Secretion System 2 in Vibrio parahaemolyticus. PLoS One. 8(8):e73363. [PudMed:23977385] [7] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | PAAR | TagJ | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| VP_RS20045 | 1069624..1070757 | - | 1134 | WP_005480347.1 | multidrug effflux MFS transporter | ||
| VP_RS20050 | 1070897..1071676 | + | 780 | WP_011106404.1 | helix-turn-helix transcriptional regulator | ||
| VP_RS20055 | 1071695..1072216 | - | 522 | WP_005463837.1 | lipocalin family protein | ||
| VP_RS20060 | 1072272..1072799 | - | 528 | WP_005463834.1 | phosphoglycerate mutase family protein | ||
| VP_RS20065 | 1072830..1073354 | - | 525 | WP_005480324.1 | AAA family ATPase | ||
| VP_RS20070 | 1073763..1074143 | + | 381 | WP_005480328.1 | pyruvate dehydrogenase | ||
| VP_RS20075 | 1074208..1077264 | - | 3057 | WP_005480361.1 | SMC family ATPase | ||
| VP_RS20080 | 1077274..1078407 | - | 1134 | WP_005480232.1 | exonuclease SbcCD subunit D | ||
| VP_RS20085 | 1078504..1079346 | - | 843 | WP_005480244.1 | hypothetical protein | ||
| T6CP011352 | PAAR | VP_RS20090 | 1079347..1079637 | - | 291 | WP_005499010.1 | PAAR domain-containing protein |
| T6CP000366 | TssI | VP_RS20095 (tssI) | 1079651..1081486 | - | 1836 | WP_005480263.1 | type VI secretion system tip protein VgrG |
| T6CP000367 | TssD | VP_RS20100 | 1081544..1082023 | - | 480 | WP_005375967.1 | type VI secretion system tube protein Hcp |
| T6CP000368 | TssH | VP_RS20105 (tssH) | 1082229..1084796 | - | 2568 | WP_005480296.1 | type VI secretion system ATPase TssH |
| T6CP000369 | TssG | VP_RS20110 (tssG) | 1084807..1085772 | - | 966 | WP_005480294.1 | type VI secretion system baseplate subunit TssG |
| T6CP000370 | TssF | VP_RS20115 (tssF) | 1085769..1087592 | - | 1824 | WP_005463819.1 | type VI secretion system baseplate subunit TssF |
| T6CP000371 | TssE | VP_RS20120 (tssE) | 1087589..1088053 | - | 465 | WP_005463817.1 | type VI secretion system baseplate subunit TssE |
| T6CP012705 | TagJ | VP_RS20125 | 1088062..1088859 | - | 798 | WP_005463815.1 | protein of avirulence locus |
| T6CP000372 | TssC | VP_RS20130 (tssC) | 1088870..1090381 | - | 1512 | WP_005480259.1 | type VI secretion system contractile sheath large subunit |
| T6CP000373 | TssC | VP_RS20135 (tssC) | 1090437..1091930 | - | 1494 | WP_005463811.1 | type VI secretion system contractile sheath large subunit |
| T6CP000374 | TssB | VP_RS20140 (tssB) | 1091930..1092460 | - | 531 | WP_005463809.1 | type VI secretion system contractile sheath small subunit |
| T6CP009338 | TssA | VP_RS20145 (tssA) | 1092476..1093597 | - | 1122 | WP_005480330.1 | type VI secretion system protein TssA |
| VP_RS20150 | 1093594..1094382 | - | 789 | WP_005463805.1 | protein phosphatase 2C domain-containing protein | ||
| VP_RS20155 (tagF) | 1094393..1095088 | - | 696 | WP_005463803.1 | type VI secretion system-associated protein TagF | ||
| T6CP000375 | TssM | VP_RS20160 (tssM) | 1095070..1098588 | - | 3519 | WP_005463801.1 | type VI secretion system membrane subunit TssM |
| T6CP000376 | TssL | VP_RS20165 (tssL) | 1098604..1099896 | - | 1293 | WP_005463799.1 | type VI secretion system protein TssL, long form |
| T6CP000377 | TssK | VP_RS20170 (tssK) | 1099908..1101233 | - | 1326 | WP_005463797.1 | type VI secretion system baseplate subunit TssK |
| T6CP000378 | TssJ | VP_RS20175 (tssJ) | 1101255..1101710 | - | 456 | WP_005463795.1 | type VI secretion system lipoprotein TssJ |
| T6CP011353 | FHA | VP_RS20180 (tagH) | 1101720..1102916 | - | 1197 | WP_005463793.1 | type VI secretion system-associated FHA domain protein TagH |
| VP_RS20185 | 1103239..1105380 | + | 2142 | WP_005480257.1 | serine/threonine protein kinase | ||
| VP_RS20190 | 1105492..1107027 | + | 1536 | WP_005463789.1 | response regulator | ||
| VP_RS20195 | 1107030..1107365 | + | 336 | WP_005463787.1 | hypothetical protein | ||
| VP_RS20200 | 1107401..1107592 | + | 192 | WP_005480239.1 | hypothetical protein | ||
| VP_RS20205 | 1107620..1108114 | - | 495 | WP_005480282.1 | ATP-binding protein | ||
| VP_RS20210 | 1108107..1109327 | - | 1221 | WP_005463782.1 | SpoIIE family protein phosphatase | ||
| VP_RS20215 | 1109352..1109612 | - | 261 | WP_005463779.1 | hypothetical protein | ||
| VP_RS20220 | 1109834..1110448 | - | 615 | WP_005463777.1 | glutathione S-transferase | ||
| VP_RS20225 | 1110593..1111168 | + | 576 | WP_005463775.1 | TetR/AcrR family transcriptional regulator | ||
| VP_RS20230 | 1111170..1111574 | + | 405 | WP_005463773.1 | DUF296 domain-containing protein | ||
| VP_RS20235 (nirD) | 1111677..1112012 | - | 336 | WP_005463771.1 | nitrite reductase small subunit NirD |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed. Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF00061 |
VP_RS20100 | - | - | Vibrio parahaemolyticus RIMD 2210633 | chromosome (NC_004605) | 1081544..1082023 (-) | 28900882 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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