Detailed information of regulator


Summary

Regulator ID REG0111 experimental
Regulator type protein
Regulatory pathway (from literatures) QS regulatory pathway
KEGG pathway (determined by BlastKOALA) Quorum sensing (map02024); Biofilm formation - Vibrio cholerae (map05111)
Related T6SS T6SS00043 experimental (Type i1); T6SS00044 experimental (Type i5)
Strain Vibrio parahaemolyticus RIMD 2210633
Replicon chromosome
Sequence Protein sequence (180 a.a.); Nucleotide sequence (540 bp)
Description AphA appears to negatively regulate the transcription of T6SS2 in an indirect manner.; AphA appears to negatively regulate the transcription of VPA1027-1024, VPA1043-1028, and VPA1044-1046 in an indirect manner.
Reference

External database links

Locus tag (Gene) VP2762 (AphA)
Coordinates (Strand) 2929909..2930448 (+)
NCBI ID 28899536
RefSeq NC_004603
Uniprot ID Q87L53_VIBPA
KEGG ID vpa:VP2762
KEGG pathway (determined by BlastKOALA) map02024; map05111
PDB ID -

  Target
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Target
Regulation (↓/↑)
Target sequence
T6SS1 transcript-
T6SS2 (VPA1027-1024, VPA1043-1028,VPA1044-1046) transcripts-
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Pfam domain hit(s) of regulator

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Domain
Pfam ID
E-value
Aligned region
PadRPF03551.161.2e-157..80
Vir_act_alpha_CPF10400.114.6e-1592..176
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Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction                
Region    
Sequence
Outside1-179MSLPHVILTVLSTRDATGYDITKEFSASIGYFWKASHQQVYRELNKMAEKELVTCVLEPQEGKPDRKVYSITDAGRSALGEWFDQPTAHPTVRDEFSAKLMACAVQPSTPFRDQLAELVEESRKLVSHYKEIEAAYYATPSTLDKQARLERLTLRRNLLLRETWITWAEEVLTELEVIG



Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction       
Probability
Cleavage site
Signal peptide sequence
Other0.9045--



  Protein sequence of regulator: 180 a.a.    .

>REG0111 NC_004603:2929909-2930448 [Vibrio parahaemolyticus RIMD 2210633]
MSLPHVILTVLSTRDATGYDITKEFSASIGYFWKASHQQVYRELNKMAEKELVTCVLEPQEGKPDRKVYSITDAGRSALG
EWFDQPTAHPTVRDEFSAKLMACAVQPSTPFRDQLAELVEESRKLVSHYKEIEAAYYATPSTLDKQARLERLTLRRNLLL
RETWITWAEEVLTELEVIG*

  Nucleotide sequence of regulator: 540 bp    .

>REG0111 NC_004603:2929909-2930448 [Vibrio parahaemolyticus RIMD 2210633]
ATGTCATTACCACACGTAATCTTAACTGTTCTTAGCACTCGCGACGCAACCGGTTACGATATCACTAAAGAATTCTCTGC
TAGCATCGGTTACTTCTGGAAAGCAAGCCACCAACAAGTTTACCGTGAACTAAATAAAATGGCCGAGAAAGAGCTGGTTA
CTTGCGTACTAGAACCTCAAGAAGGCAAACCAGACCGTAAGGTTTACTCCATCACAGATGCAGGCCGTAGCGCTCTTGGA
GAATGGTTTGATCAACCAACTGCACACCCAACCGTTCGTGATGAATTTTCAGCGAAACTTATGGCTTGTGCTGTTCAACC
ATCAACACCTTTCCGTGATCAACTAGCAGAACTTGTTGAAGAGTCTCGTAAACTGGTTTCTCACTACAAAGAAATTGAAG
CTGCTTACTACGCAACGCCTTCAACTTTGGACAAACAAGCTCGTTTAGAGCGCCTAACGCTTCGTCGTAACCTACTGTTA
CGTGAAACGTGGATCACTTGGGCAGAAGAAGTCCTAACAGAACTTGAAGTGATTGGTTAA