Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00043  |
| T6SS type | Type i1 |
| Strain | Vibrio parahaemolyticus RIMD 2210633 |
| Replicon (RefSeq) | chromosome I (NC_004603) |
| Location | 1486402..1526996 |
| Function | anti-eukaryotic; anti-bacterial; effector translocation; adherence; virulence |
| Comment | Adhesion to cultured cell monolayers; V. parahaemolyticus T6SS1 effectors mediate its antibacterial activity. |
| References | [1] Salomon D et al (2014) Marker for type VI secretion system effectors. Proc Natl Acad Sci U S A. 111(25):9271-6. [PudMed:24927539] [2] Ma L et al (2012) Expression of the Type VI Secretion System 1 Component Hcp1 Is Indirectly Repressed by OpaR in Vibrio parahaemolyticus. Scientific World Journal. 2012:982140. [PudMed:22924031] [3] Yu Y et al (2012) Putative type VI secretion systems of Vibrio parahaemolyticus contribute to adhesion to cultured cell monolayers. Arch Microbiol. 194(10):827-35. [PudMed:22535222] [4] Salomon D et al (2014) H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1. Microbiology. 160(Pt 9):1867-73. [PudMed:24987102] [5] Salomon D et al (2013) Vibrio parahaemolyticus Type VI Secretion System 1 Is Activated in Marine Conditions to Target Bacteria, and Is Differentially Regulated from System 2. PLoS One. 8(4):e61086. [PudMed:23613791] [6] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TagL | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| VP_RS06745 | 1483454..1485205 | + | 1752 | WP_029793730.1 | hypothetical protein | ||
| VP_RS06750 | 1485278..1486405 | + | 1128 | WP_005480747.1 | hypothetical protein | ||
| T6CP011350 | TagL | VP_RS06755 | 1486402..1491144 | + | 4743 | WP_005480617.1 | OmpA family protein |
| VP_RS06760 | 1491226..1492857 | - | 1632 | WP_005480672.1 | sigma-54 dependent transcriptional regulator | ||
| T6CP000356 | TssH | VP_RS06765 (tssH) | 1492844..1495516 | - | 2673 | WP_005480775.1 | type VI secretion system ATPase TssH |
| T6CP008427 | TssD | VP_RS06770 | 1495971..1496489 | + | 519 | WP_005480650.1 | Hcp family type VI secretion system effector |
| T6CP000357 | TssI | VP_RS06775 (tssI) | 1496562..1498640 | + | 2079 | WP_005480708.1 | type VI secretion system tip protein VgrG |
| VP_RS06780 | 1498640..1499125 | + | 486 | WP_005480759.1 | hypothetical protein | ||
| VP_RS06785 | 1499195..1500536 | + | 1342 | pseudogene | hypothetical protein | ||
| VP_RS06790 | 1500517..1501509 | + | 993 | WP_005480591.1 | DUF2169 domain-containing protein | ||
| VP_RS06795 | 1501502..1502446 | + | 945 | WP_005480706.1 | hypothetical protein | ||
| VP_RS06800 | 1502681..1504684 | + | 2004 | WP_005480632.1 | protein kinase family protein | ||
| T6CP008428 | TssA | VP_RS06805 (tssA) | 1504684..1506258 | + | 1575 | WP_005480735.1 | type VI secretion system protein TssA |
| T6CP000358 | TssB | VP_RS06810 (tssB) | 1506285..1506791 | + | 507 | WP_005480589.1 | type VI secretion system contractile sheath small subunit |
| T6CP000359 | TssC | VP_RS06815 (tssC) | 1506800..1508275 | + | 1476 | WP_005480731.1 | type VI secretion system contractile sheath large subunit |
| T6CP008429 | TssE | VP_RS06820 (tssE) | 1508337..1508747 | + | 411 | WP_005480585.1 | type VI secretion system baseplate subunit TssE |
| T6CP000360 | TssF | VP_RS06825 (tssF) | 1508758..1510506 | + | 1749 | WP_005480666.1 | type VI secretion system baseplate subunit TssF |
| T6CP000361 | TssG | VP_RS06830 (tssG) | 1510503..1511501 | + | 999 | WP_005480692.1 | type VI secretion system baseplate subunit TssG |
| VP_RS06835 | 1511565..1512017 | - | 453 | WP_005480668.1 | Lrp/AsnC family transcriptional regulator | ||
| T6CP000362 | TssM | VP_RS06840 (tssM) | 1512050..1515439 | - | 3390 | WP_005480685.1 | type VI secretion system membrane subunit TssM |
| T6CP008430 | TssA | VP_RS06845 | 1515461..1516756 | - | 1296 | WP_005480614.1 | type VI secretion system ImpA family N-terminal domain-containing protein |
| VP_RS06850 | 1517276..1517875 | + | 600 | WP_005480745.1 | hypothetical protein | ||
| T6CP011351 | FHA | VP_RS06855 | 1517885..1519399 | + | 1515 | WP_005480584.1 | FHA domain-containing protein |
| T6CP000363 | TssJ | VP_RS06860 (tssJ) | 1519392..1519892 | + | 501 | WP_011105829.1 | type VI secretion system lipoprotein TssJ |
| T6CP000364 | TssK | VP_RS06865 (tssK) | 1519904..1521229 | + | 1326 | WP_005480714.1 | type VI secretion system baseplate subunit TssK |
| T6CP000365 | TssL | VP_RS06870 | 1521226..1522017 | + | 792 | WP_005449458.1 | type IVB secretion system protein IcmH/DotU |
| VP_RS06875 | 1522167..1524323 | + | 2157 | WP_005480648.1 | DUF4150 domain-containing protein | ||
| VP_RS06880 | 1524323..1524916 | + | 594 | WP_005480679.1 | hypothetical protein | ||
| VP_RS06885 | 1524916..1525467 | + | 552 | WP_005480782.1 | hypothetical protein | ||
| VP_RS06890 | 1525615..1526144 | + | 530 | pseudogene | hypothetical protein | ||
| VP_RS06895 | 1526553..1526996 | + | 444 | WP_005480602.1 | hypothetical protein | ||
| VP_RS06900 | 1527018..1527506 | + | 489 | WP_005480696.1 | hypothetical protein | ||
| VP_RS06905 | 1527691..1527984 | + | 294 | WP_005480582.1 | hypothetical protein | ||
| VP_RS06910 | 1528144..1528746 | + | 603 | WP_005454888.1 | 2OG-Fe(II) oxygenase | ||
| VP_RS06915 | 1528811..1530076 | - | 1266 | WP_005480753.1 | HD-GYP domain-containing protein | ||
| VP_RS06920 | 1530652..1531842 | + | 1191 | WP_005454895.1 | iron-containing alcohol dehydrogenase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed. Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01294 |
VP_RS06875 | Tde | IMU00052 |
Vibrio parahaemolyticus RIMD 2210633 | chromosome (NC_004603) | 1522167..1524323 (+) | 28898189 |
| EFF01295 |
VP_RS21220 | Tde | - | Vibrio parahaemolyticus RIMD 2210633 | chromosome (NC_004605) | 1341875..1344451 (+) | 28901118 |
| EFF01293 |
VP_RS06745 | Tse | IMU00051 |
Vibrio parahaemolyticus RIMD 2210633 | chromosome (NC_004603) | 1483454..1485205 (+) | 28898162 |
| EFF00060 |
VP_RS06770 | - | - | Vibrio parahaemolyticus RIMD 2210633 | chromosome (NC_004603) | 1495971..1496489 (+) | 28898167 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00051 |
VP_RS06750 | EFF01293 |
Vibrio parahaemolyticus RIMD 2210633 | chromosome (NC_004603) | 1485278..1486405 (+) | 28898163 |
| IMU00052 |
VP_RS06880 | EFF01294 |
Vibrio parahaemolyticus RIMD 2210633 | chromosome (NC_004603) | 1524323..1524916 (+) | 28898190 |
| IMU00275 |
Vti2 | - | Vibrio parahaemolyticus RIMD 2210633 | chromosome (NC_004605) | - |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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