Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00070  |
| T6SS type | Type i1 |
| Strain | Burkholderia mallei ATCC 23344 |
| Replicon (RefSeq) | chromosome II (NC_006349) |
| Location | 735641..772695 |
| Function | anti-eukaryotic; effector translocation; virulence |
| Comment | Virulence in Syrian hamster model; intracellular growth, actin polymerisation and mononuclear giant cell formation in cultured macrophages. |
| References | [1] Shanks J et al (2009) Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophages. Infect Immun. 77(4):1636-48. [PudMed:19168747] [2] Schell MA et al (2007) Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol. 64(6):1466-85. [PudMed:17555434] [3] Fisher NA et al (2012) The Madagascar hissing cockroach as a novel surrogate host for Burkholderia pseudomallei, B. mallei and B. thailandensis. BMC Microbiol. 0.58125. [PudMed:22892068] [4] Burtnick MN et al (2010) Burkholderia mallei cluster 1 type VI secretion mutants exhibit growth and actin polymerization defects in RAW 264.7 murine macrophages. Infect Immun. 78(1):88-99. [PudMed:19884331] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM | VirA | VirG |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BMA_RS19500 | 732317..732814 | - | 498 | WP_004201904.1 | hypothetical protein | ||
| BMA_RS19505 | 732932..733816 | - | 885 | WP_004266679.1 | metal-dependent hydrolase | ||
| BMA_RS19510 | 733927..735047 | - | 1121 | WP_038802950.1 | IS3 family transposase | ||
| BMA_RS19515 | 735241..735548 | - | 308 | pseudogene | DDE-type integrase/transposase/recombinase | ||
| BMA_RS19520 | 735641..736273 | - | 633 | WP_004528803.1 | GTP cyclohydrolase I | ||
| BMA_RS19525 | 736278..736571 | - | 294 | WP_004551882.1 | type VI secretion system protein TssN | ||
| BMA_RS19530 | 736530..736775 | + | 246 | WP_004201911.1 | hypothetical protein | ||
| BMA_RS19535 | 736735..737958 | - | 1224 | WP_162473488.1 | Ig-like domain-containing protein | ||
| T6CP008459 | TssM | BMA_RS19540 (tssM-5) | 738692..742738 | - | 4047 | WP_174977041.1 | type VI secretion system membrane subunit TssM-5 |
| T6CP000596 | TssL | BMA_RS19545 | 742735..743400 | - | 666 | WP_004184888.1 | type VI secretion system protein TssL |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
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Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0126 | BMAA1517 | protein | Transcription regulator | Burkholderia mallei ATCC 23344 | chromosome (NC_006349) | 1646532..1647593 (-) | 499517952 | Hcp1 (BMAA0742) expression (↓) |
| REG0127 | BMAA0746 (VirG) | protein | TCS-RR | Burkholderia mallei ATCC 23344 | chromosome (NC_006349) | 764773..765510 (+) | 490311617 | Hcp1 (BMAA0742) expression (↓) |
| REG0128 | BMAA0745 (VirA) | protein | TCS-HK | Burkholderia mallei ATCC 23344 | chromosome (NC_006349) | 762932..764776 (+) | 490305845 | Hcp1 (BMAA0742) expression (↓) |
| REG0129 | BMAA0746 (VirG) | protein | TCS-RR | Burkholderia mallei ATCC 23344 | chromosome (NC_006349) | 764773..765510 (+) | 53717366 | BMAA0742 (Hcp1) expression (↓); BMAA0729.1 (TssM1) expression (↓) |
| REG0130 | BMAA0745 (VirA) | protein | TCS-HK | Burkholderia mallei ATCC 23344 | chromosome (NC_006349) | 763148..764776 (+) | 53717365 | BMAA0746 (VirG) (↓) |
Showing 1 to 5 of 5 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF00086 | BMA_RS19535 | Tse | - | Burkholderia mallei ATCC 23344 | chromosome (NC_006349) | 736735..737958 (-) | 77358950 |
| EFF00087 | BMA_RS19580 | - | - | Burkholderia mallei ATCC 23344 | chromosome (NC_006349) | 750563..753586 (-) | 53717363 |
| EFF00088 | BMA_RS19605 | - | - | Burkholderia mallei ATCC 23344 | chromosome (NC_006349) | 759926..760435 (-) | 77358963 |
Showing 1 to 3 of 3 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| No matching records found | ||||||
Experimental investigation has been performed.
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||