Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01264  |
| T6SS type | Type i3 |
| Strain | Serratia marcescens RM66262 |
| Replicon (RefSeq) | chromosome (NZ_JWLO01000001) |
| Location | 563798..601203 |
| Function | anti-bacterial |
| Comment | T6SS endows S.marcescens T6SS-mediated intraspecies competition and hcp secretion |
| References | [1] Lazzaro M, Feldman MF, Garc��a V��scovi E. et al (2017) A Transcriptional Regulatory Mechanism Finely Tunes the Firing of Type VI Secretion System in Response to Bacterial Enemies.. mBio. 8(4). [PudMed:28830939] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TagF | TagH | TagJ | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| RT90_RS02595 | 559726..560298 | + | 573 | 1217739707 | YkgB family protein | ||
| RT90_RS02600 | 560295..560750 | + | 456 | 1160807027 | DUF302 domain-containing protein | ||
| RT90_RS02605 | 560788..562125 | + | 1338 | 727185948 | pyridine nucleotide-disulfide oxidoreductase | ||
| RT90_RS02610 (kynA) | 562274..563116 | + | 843 | 727162862 | tryptophan 2,3-dioxygenase | ||
| RT90_RS02615 (sbmC) | 563139..563606 | + | 468 | 746532416 | DNA gyrase inhibitor SbmC | ||
| T6CP015741 | TssI | RT90_RS02620 (tssI) | 563798..565726 | - | 1929 | 727191838 | type VI secretion system tip protein VgrG |
| RT90_RS02625 | 565868..567301 | - | 1434 | 746532418 | serine/threonine protein kinase | ||
| T6CP015742 | TssH | RT90_RS02630 (tssH) | 567351..570005 | - | 2655 | 746532421 | type VI secretion system ATPase TssH |
| T6CP015743 | TssG | RT90_RS02635 (tssG) | 570062..571132 | - | 1071 | 727185942 | type VI secretion system baseplate subunit TssG |
| T6CP015744 | TssF | RT90_RS02640 (tssF) | 571129..573015 | - | 1887 | 746532425 | type VI secretion system baseplate subunit TssF |
| T6CP015745 | TssE | RT90_RS02645 | 573020..573595 | - | 576 | 727162842 | GPW/gp25 family protein |
| T6CP015746 | TagJ | RT90_RS02650 | 573598..574401 | - | 804 | 746532430 | protein of avirulence locus ImpE |
| RT90_RS02655 | 574435..575421 | - | 987 | 746532433 | hypothetical protein | ||
| RT90_RS02660 | 575450..576223 | - | 774 | 505191187 | serine/threonine-protein phosphatase | ||
| T6CP015747 | TagH | RT90_RS02665 (tagH) | 576223..577953 | - | 1731 | 746532437 | type VI secretion system-associated FHA domain protein TagH |
| RT90_RS22750 | 578187..578549 | - | 363 | 1108650074 | hypothetical protein | ||
| RT90_RS02670 | 578595..578957 | - | 363 | 727185939 | type VI secretion protein | ||
| RT90_RS22755 | 578961..579419 | - | 459 | 727191848 | type VI secretion system amidase immunity protein Tai4 | ||
| RT90_RS22760 | 579416..579919 | - | 504 | 1108650073 | type VI secretion system amidase effector protein Tae4 | ||
| T6CP015748 | TssD | RT90_RS02675 | 579969..580451 | - | 483 | 491099772 | type VI secretion system tube protein Hcp |
| RT90_RS02680 | 580750..581241 | - | 492 | 640737159 | hypothetical protein | ||
| RT90_RS02685 | 581238..581621 | - | 384 | 644359376 | hypothetical protein | ||
| T6CP015749 | TssC | RT90_RS02690 (tssC) | 581689..583194 | - | 1506 | 515494005 | type VI secretion system contractile sheath large subunit |
| T6CP015750 | TssB | RT90_RS02695 (tssB) | 583198..583734 | - | 537 | 727162830 | type VI secretion system contractile sheath small subunit |
| T6CP015751 | TssA | RT90_RS02700 (tssA) | 583856..584887 | - | 1032 | 727191850 | type VI secretion system protein TssA |
| T6CP015752 | TagF | RT90_RS02705 (tagF) | 584911..585630 | - | 720 | 727185937 | type VI secretion system-associated protein TagF |
| T6CP015753 | TssM | RT90_RS02710 (tssM) | 585649..589284 | - | 3636 | 727185935 | type VI secretion system membrane subunit TssM |
| T6CP015754 | TssL | RT90_RS02715 | 589284..590486 | - | 1203 | 896288904 | DotU family type VI secretion system protein |
| T6CP015755 | TssK | RT90_RS02720 (tssK) | 590508..591854 | - | 1347 | 727170789 | type VI secretion system baseplate subunit TssK |
| T6CP015756 | TssJ | RT90_RS02725 (tssJ) | 591895..592425 | - | 531 | 913459525 | type VI secretion system lipoprotein TssJ |
| RT90_RS02730 | 592455..592955 | - | 501 | 727186279 | hypothetical protein | ||
| RT90_RS02735 | 593000..593392 | - | 393 | 491073311 | DUF4150 domain-containing protein | ||
| RT90_RS02740 | 593409..594044 | - | 636 | 727162818 | DUF3540 domain-containing protein | ||
| RT90_RS02745 | 594075..595142 | - | 1068 | 727185933 | pentapeptide repeat-containing protein | ||
| RT90_RS02750 | 595139..597691 | - | 2553 | 746532454 | DUF2169 domain-containing protein | ||
| RT90_RS02755 | 597862..598362 | - | 501 | 746532457 | hypothetical protein | ||
| RT90_RS02760 | 598464..598853 | - | 390 | 727185930 | hypothetical protein | ||
| T6CP015757 | TssI | RT90_RS02765 (tssI) | 598864..601203 | - | 2340 | 727185929 | type VI secretion system tip protein VgrG |
| RT90_RS02770 | 601716..602648 | - | 933 | 727185928 | LysR family transcriptional regulator | ||
| RT90_RS02775 (pcp) | 602746..603393 | + | 648 | 727186278 | pyroglutamyl-peptidase I | ||
| RT90_RS02780 | 603428..604462 | - | 1035 | 727185927 | NADP-dependent oxidoreductase | ||
| RT90_RS02785 (uspC) | 604548..604967 | - | 420 | 727162799 | universal stress protein UspC | ||
| RT90_RS02790 (ydgT) | 605165..605380 | - | 216 | 746532472 | transcription modulator YdgT |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0003 |
RT90_01105 (rcsC) | protein | TCS-HK | Serratia marcescens strain RM66262 | chromosome (JWLO01000001) | 232638..235499 (+) | 735006326 | RT90_01115 (rcsB) (↑) |
| REG0004 |
RT90_01115 (rcsB) | protein | TCS-RR | Serratia marcescens strain RM66262 | chromosome (JWLO01000001) | 235561..236211 (-) | 735006328 | vgrG promoter (↓) |
| REG0005 |
RT90_16255 (wecG) | protein | TCS regulatory pathway | Serratia marcescens strain RM66262 | chromosome (JWLO01000003) | 92056..92796 (-) | 735005313 | RT90_01105 (rcsC) (↑) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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