Detailed information of effector


Summary

Effector ID EFF00203 experimental
Effector type -
Cognate immunity protein -
Related T6SS (Type) T6SS00158 experimental (Type ii)
Strain Francisella tularensis subsp. novicida U112
Replicon chromosome
Sequence Protein sequence (165 a.a.); Nucleotide sequence (495 bp)
Description Required for F. tularensis phagosomal escape, intramacrophage growth, virulence, and induction of IL1-beta expression by infected macrophages
Reference
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed

External database links

Locus tag (Gene) FTN_1312 (VgrG)
Coordinates (Strand) 1384422..1384916 (+)
NCBI ID 118497892
RefSeq NC_008601
Uniprot ID UPI00001A955A
KEGG ID -
PDB ID -

Pfam domain hit(s)

Domain Pfam ID E-value Aligned region

Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Outside 1-164 MSKADHIFNLEEQGLLIDIKDDSKGCTTKLESSGKITHNATESIESSADKQIIENVKDSKISITEKEILLATKKSSIMLSEDKIVIKIGNSLIILDDSNISLESATINIKSSANINIQASQNIDIKSLNNSIKADVNLNAEGLDVNIKGSVTASIKGSAATMVG



Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9898 - -



  Protein sequence: 165 a.a.    .

>EFF00203 NC_008601:1384422-1384916 [Francisella tularensis subsp. novicida U112]
MSKADHIFNLEEQGLLIDIKDDSKGCTTKLESSGKITHNATESIESSADKQIIENVKDSKISITEKEILLATKKSSIMLS
EDKIVIKIGNSLIILDDSNISLESATINIKSSANINIQASQNIDIKSLNNSIKADVNLNAEGLDVNIKGSVTASIKGSAA
TMVG*

  Nucleotide sequence: 495 bp    .

>EFF00203 NC_008601:1384422-1384916 [Francisella tularensis subsp. novicida U112]
ATGTCAAAAGCAGACCATATTTTCAACTTAGAAGAGCAAGGCTTGCTCATAGATATCAAAGATGATTCAAAAGGCTGCAC
TACGAAACTAGAGTCCTCTGGAAAAATTACTCATAATGCAACTGAATCGATAGAGTCAAGCGCTGATAAACAAATAATTG
AAAATGTTAAAGACTCAAAAATATCAATAACTGAAAAAGAAATTTTGTTAGCTACTAAGAAATCAAGCATTATGCTTAGT
GAAGATAAAATTGTCATAAAAATAGGTAATTCTTTAATTATACTTGATGATTCAAATATTTCGCTAGAGTCTGCAACTAT
TAATATAAAAAGCTCTGCTAATATAAATATTCAAGCATCGCAGAACATAGATATAAAAAGTCTAAATAATAGTATCAAAG
CAGATGTAAACCTTAATGCTGAAGGATTAGATGTAAATATTAAAGGAAGTGTAACAGCAAGTATAAAAGGTTCCGCAGCA
ACAATGGTTGGATAA