Detailed information of regulator


Summary

Regulator ID REG0171 experimental
Regulator type protein
Regulatory pathway (from literatures) Global regulator
KEGG pathway (determined by BlastKOALA) -
Related T6SS T6SS00155 insolico (Type i1)
Strain Escherichia coli APEC O1
Replicon chromosome
Sequence Protein sequence (251 a.a.); Nucleotide sequence (753 bp)
Description FNR direct regulates vgrG by binding to the promoter regions of vgrG.
Reference
External database links

Locus tag (Gene) APECO1_487 (FNR)
Coordinates (Strand) 1455411..1456163 (-)
NCBI ID 446534565
RefSeq NC_008563
Uniprot ID A0A1Z3V448_ECOLX, M9HB23_ECOLX, A0A0E0Y365_ECO1C, K4VQL4_ECOLX, S1PCV1_ECOLX, L3BJQ1_ECOLX, S1FA01_ECOLX, L3Q8C5_ECOLX, S1ID30_ECOLX, L4JBT0_ECOLX, A0A0E2L6M2_ECOU3, A0A080J5H3_ECOLX, A0A029I3S7_ECOLX, FNR_ECOL6, A0A2S6PGK2_9ESCH, D3H4B3_ECO44, E3PL94_ECOH1, A7ZLG3_ECO24, A0A0E1SWC2_ECOLX, B1LG94_ECOSM, J7QL32_ECOLX, B1EN40_ESCAT, D6I8B9_ECOLX, D6JAN1_ECOLX, A0A1X3JW05_9ESCH, E0IUS3_ECOLW, A0A170LX84_KLEOX, B7URE2_ECO27, B7MM10_ECO45, B7L599_ECO55, B7N4E1_ECOLU, A0A0H3MGI3_ECO7I, B7MUH6_ECO81, A0A1Q8MP94_SHIBO, A0A1Q8NL43_SHIDY, FNR_SHIFL, A0A1W2MAD0_SHIFL, A0A0I4TZB2_SHISO, A0A0K9T8H6_ECOLX, A0A1X3LIR5_ECOLX, A0A1X3LWY8_ECOLX, E9XLR4_ECOLX, A0A0H3EIG8_ECO8N, D3QS94_ECOCB, A0A0E1LX03_ECOLX, I4SI67_ECOLX, FNR_ECOLI, FNR_ECO57, I2SMN0_ECOLX, I2UFL2_ECOLX, I2WNH3_ECOLX
KEGG ID ece:Z2433, eln:NRG857_06845, ecs:ECs1915, ecz:ECS88_1476, elo:EC042_1451, sfl:SF1836, elh:ETEC_1438, elw:ECW_m1431, ecm:EcSMS35_1788, sfx:S1434, esl:O3K_13655, eck:EC55989_1498, ecc:c1807, sft:NCTC1_01980, eok:G2583_1682, eum:ECUMN_1629, ecq:ECED1_1544, ect:ECIAI39_1683, ecj:JW1328, ecg:E2348C_1527, eco:b1334, ecw:EcE24377A_1546
KEGG pathway (determined by BlastKOALA) -
PDB ID -
  Target
Target Regulation (↓/↑) Target sequence
APECO1_1756 (VgrG1) ↓ aaggttgagtgggagcacatcaaatccggtacttctggtgccgatgactggcgtgcaccgctggaagcataaatctgagtcaacaacatcctgcctccgtgcaggatgttgtttttgtacgtgtaaaaaatgagtgtcagtaaggagttacgctttcatgagggagatggtggatgccggaaacccgggcggtagcgtacctgaaaatgtaaagatgagtgtaacgctgcactggcaccctttgctgcatggtgggaatcatttggtccgtgaatgaatcagggaggtcattatgtccttaaaaggtcttcgctttacgctggaggttgacg
Pfam domain hit(s) of regulator

Domain Pfam ID E-value Aligned region
Crp PF00325.22 3.3e-16 193..224
cNMP_binding PF00027.31 1.4e-15 51..132
Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Outside 1-250 MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGSGHHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENNDALAQLAGHTRNVA


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9760 - -


  Protein sequence of regulator: 251 a.a.    .

>REG0171 NC_008563:c1456163-1455411 [Escherichia coli APEC O1]
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGSGHHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENNDALA
QLAGHTRNVA*

  Nucleotide sequence of regulator: 753 bp    .

>REG0171 NC_008563:c1456163-1455411 [Escherichia coli APEC O1]
ATGATCCCGGAAAAGCGAATTATACGGCGCATTCAGTCTGGCGGTTGTGCTATCCATTGCCAGGATTGCAGCATCAGCCA
GCTTTGCATCCCGTTCACACTCAACGAACATGAGCTTGATCAGCTTGATAATATCATTGAGCGGAAGAAGCCTATTCAGA
AAGGCCAGACGCTGTTTAAGGCTGGAGATGAACTAAAATCGCTTTATGCCATCCGCTCCGGTACGATTAAAAGTTATACC
ATCACTGAGCAAGGCGACGAGCAAATCACTGGTTTCCATTTAGCAGGCGATCTGGTGGGATTTGATGCCATCGGCAGCGG
TCATCACCCGAGTTTCGCGCAGGCGCTGGAAACCTCGATGGTATGTGAAATCCCGTTCGAAACGCTGGACGATTTGTCTG
GTAAAATGCCGAATCTGCGTCAGCAGATGATGCGTCTGATGAGCGGTGAAATCAAAGGCGATCAGGACATGATCCTGCTG
TTGTCGAAGAAAAATGCCGAGGAACGTCTGGCTGCATTCATCTACAACCTGTCCCGTCGTTTTGCCCAACGCGGCTTCTC
CCCTCGTGAATTCCGCCTGACGATGACTCGTGGTGATATCGGTAACTATCTGGGCCTGACGGTTGAAACCATCAGCCGTC
TGCTGGGTCGCTTCCAGAAAAGCGGTATGCTGGCAGTCAAAGGTAAATACATCACTATCGAAAATAACGATGCGCTGGCC
CAGCTTGCTGGTCATACGCGTAACGTTGCCTGA