Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00155  |
| T6SS type | Type i1 |
| Strain | Escherichia coli APEC O1 |
| Replicon (RefSeq) | chromosome (NC_008563) |
| Location | 237543..271625 |
| Function | - |
| Comment | - |
| References | [1] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] |
Bioinformatics investigation has been performed.T6SS components and genome coordinates
| Component | FHA | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| APECO1_RS01090 (dkgB) | 233893..234696 | + | 804 | WP_000997016.1 | 2,5-didehydrogluconate reductase DkgB | ||
| APECO1_RS01095 (yafC) | 234693..235607 | - | 915 | WP_000648548.1 | LysR family transcriptional regulator | ||
| APECO1_RS01100 (yafD) | 235848..236648 | + | 801 | WP_001230983.1 | endonuclease/exonuclease/phosphatase family protein | ||
| APECO1_RS01105 | 236726..237496 | + | 771 | WP_000211705.1 | class I SAM-dependent methyltransferase | ||
| APECO1_RS01110 (mltD) | 237543..238901 | - | 1359 | WP_000644685.1 | murein transglycosylase D | ||
| APECO1_RS01115 (gloB) | 238973..239728 | - | 756 | WP_001052741.1 | hydroxyacylglutathione hydrolase | ||
| APECO1_RS01120 (yafS) | 239762..240484 | + | 723 | WP_001295200.1 | class I SAM-dependent methyltransferase | ||
| APECO1_RS01125 (rnhA) | 240481..240948 | - | 468 | WP_000917883.1 | ribonuclease HI | ||
| APECO1_RS01130 (dnaQ) | 241013..241744 | + | 732 | WP_001308374.1 | DNA polymerase III subunit epsilon | ||
| APECO1_RS01140 | 242282..243067 | + | 786 | WP_001049698.1 | hypothetical protein | ||
| T6CP008527 | TssD | APECO1_RS01145 | 243407..243886 | - | 480 | WP_000013181.1 | Hcp family type VI secretion system effector |
| T6CP008528 | TssA | APECO1_RS01150 | 243904..245262 | - | 1359 | WP_000073801.1 | type VI secretion system ImpA and VasL domain-containing protein |
| T6CP001515 | TssM | APECO1_RS01155 (tssM) | 245273..248740 | - | 3468 | WP_143702606.1 | type VI secretion system membrane subunit TssM |
| T6CP008529 | TssA | APECO1_RS01160 (tssA) | 248820..250262 | - | 1443 | WP_001331530.1 | type VI secretion system protein TssA |
| APECO1_RS01165 (tagO) | 250267..251010 | - | 744 | WP_000088600.1 | type VI secretion system-associated protein TagO | ||
| T6CP001516 | TssH | APECO1_RS01170 (tssH) | 251007..253766 | - | 2760 | WP_000614314.1 | type VI secretion system ATPase TssH |
| T6CP001517 | TssL | APECO1_RS01175 (icmH) | 253776..254540 | - | 765 | WP_001282178.1 | type IVB secretion system protein IcmH/DotU |
| T6CP001518 | TssK | APECO1_RS01180 (tssK) | 254545..255891 | - | 1347 | WP_000224516.1 | type VI secretion system baseplate subunit TssK |
| T6CP001519 | TssJ | APECO1_RS01185 (tssJ) | 255894..256418 | - | 525 | WP_001013423.1 | type VI secretion system lipoprotein TssJ |
| T6CP011544 | FHA | APECO1_RS01190 (tagH) | 256415..257707 | - | 1293 | WP_000433564.1 | type VI secretion system-associated FHA domain protein TagH |
| T6CP001520 | TssG | APECO1_RS01195 (tssG) | 257712..258761 | - | 1050 | WP_000896714.1 | type VI secretion system baseplate subunit TssG |
| T6CP001521 | TssF | APECO1_RS01200 (tssF) | 258725..260566 | - | 1842 | WP_000863402.1 | type VI secretion system baseplate subunit TssF |
| T6CP008530 | TssE | APECO1_RS01205 (tssE) | 260572..260997 | - | 426 | WP_000946068.1 | type VI secretion system baseplate subunit TssE |
| T6CP001522 | TssC | APECO1_RS01210 (tssC) | 261002..262486 | - | 1485 | WP_000111582.1 | type VI secretion system contractile sheath large subunit |
| T6CP001523 | TssB | APECO1_RS01215 (tssB) | 262509..263012 | - | 504 | WP_000041480.1 | type VI secretion system contractile sheath small subunit |
| T6CP008531 | TssD | APECO1_RS01220 | 263718..264236 | + | 519 | WP_001142963.1 | Hcp family type VI secretion system effector |
| T6CP001524 | TssI | APECO1_RS01230 | 264457..266439 | + | 1983 | WP_000053636.1 | type VI secretion system tip protein VgrG |
| APECO1_RS01235 | 266546..267592 | + | 1047 | WP_000571852.1 | DUF2169 domain-containing protein | ||
| T6CP011545 | PAAR | APECO1_RS01240 | 267585..269024 | + | 1440 | WP_000528853.1 | DUF4150 domain-containing protein |
| APECO1_RS01245 | 268999..269289 | + | 291 | WP_000513317.1 | hypothetical protein | ||
| APECO1_RS30090 | 269547..270311 | + | 765 | pseudogene | ISAs1 family transposase | ||
| APECO1_RS01260 | 270540..271043 | + | 504 | WP_000227712.1 | hypothetical protein | ||
| APECO1_RS01265 | 271137..271625 | + | 489 | WP_001298174.1 | integrating conjugative element protein | ||
| APECO1_RS30840 | 271651..271845 | + | 195 | pseudogene | transposase | ||
| APECO1_RS01270 (yafV) | 271896..272666 | - | 771 | WP_001118042.1 | 2-oxoglutaramate amidase | ||
| APECO1_RS01275 (ivy) | 272847..273293 | + | 447 | WP_001308392.1 | Ivy family C-type lysozyme inhibitor | ||
| APECO1_RS01280 (fadE) | 273336..275780 | - | 2445 | WP_000973137.1 | acyl-CoA dehydrogenase FadE | ||
| APECO1_RS01285 (lpcA) | 276020..276598 | + | 579 | WP_000284050.1 | D-sedoheptulose 7-phosphate isomerase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0171 |
APECO1_487 (FNR) | protein | Global regulator | Escherichia coli APEC O1 | chromosome (NC_008563) | 1455411..1456163 (-) | 446534565 | APECO1_1756 (VgrG1) (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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