Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01276  |
| T6SS type | Type i4b |
| Strain | Burkholderia cenocepacia strain K56-2 |
| Replicon (RefSeq) | chromosome (NZ_LAUA01000004) |
| Location | 63074..82939 |
| Function | anti-eukaryotic |
| Comment | T6SS plays an important role in the persistence and intracellular survival |
| References | [1] Aubert DF et al (2015) Quantification of Type VI secretion system activity in macrophages infected with Burkholderia cenocepacia. Microbiology. doi: 10.1099/mic.0.000174. [PudMed:26364149] [2] Aubert DF et al (2008) A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia. Infect Immun. 76(5):1979-91. [PudMed:18316384] [3] Aubert DF et al (2013) The Burkholderia cenocepacia sensor kinase hybrid AtsR is a global regulator modulating quorum-sensing signalling. Environ Microbiol. 15(2):372-85. [PudMed:22830644] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TagF | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| WQ49_RS11755 | 58391..59368 | + | 978 | WP_012492312.1 | zinc-binding alcohol dehydrogenase family protein | ||
| WQ49_RS36095 | 59393..59545 | + | 153 | WP_006481917.1 | DUF1427 family protein | ||
| WQ49_RS11760 | 59573..60601 | - | 1029 | WP_006481924.1 | transporter | ||
| WQ49_RS11765 | 60813..61805 | - | 993 | WP_012492311.1 | hypothetical protein | ||
| WQ49_RS11770 | 61927..62772 | + | 846 | WP_006488977.1 | M15 family metallopeptidase | ||
| T6CP015858 | TssM | WQ49_RS11775 (tssM) | 63074..67018 | + | 3945 | WP_012492310.1 | type VI secretion system membrane subunit TssM |
| T6CP015859 | TagF | WQ49_RS11780 (tagF) | 67015..68004 | + | 990 | WP_006483243.1 | type VI secretion system-associated protein TagF |
| WQ49_RS11785 | 68009..68959 | + | 951 | WP_006494417.1 | OmpA family protein | ||
| T6CP015860 | TssA | WQ49_RS11790 (tssA) | 69053..70174 | - | 1122 | WP_006484398.1 | type VI secretion system protein TssA |
| T6CP015861 | TssH | WQ49_RS11795 (tssH) | 70219..72888 | - | 2670 | WP_006484392.1 | type VI secretion system ATPase TssH |
| T6CP015862 | TssG | WQ49_RS11800 (tssG) | 72930..74030 | - | 1101 | WP_006484394.1 | type VI secretion system baseplate subunit TssG |
| T6CP015863 | TssF | WQ49_RS11805 (tssF) | 73994..75829 | - | 1836 | WP_006484396.1 | type VI secretion system baseplate subunit TssF |
| T6CP015864 | TssE | WQ49_RS11810 (tssE) | 75906..76391 | - | 486 | WP_006477092.1 | type VI secretion system baseplate subunit TssE |
| T6CP015865 | TssD | WQ49_RS11815 | 76454..76957 | - | 504 | WP_006477093.1 | type VI secretion system tube protein Hcp |
| T6CP015866 | TssC | WQ49_RS11820 (tssC) | 77028..78518 | - | 1491 | WP_006484397.1 | type VI secretion system contractile sheath large subunit |
| T6CP015867 | TssB | WQ49_RS11825 (tssB) | 78534..79049 | - | 516 | WP_006484395.1 | type VI secretion system contractile sheath small subunit |
| WQ49_RS11830 | 79096..79722 | - | 627 | WP_012492309.1 | hypothetical protein | ||
| T6CP015868 | TssJ | WQ49_RS11835 (tssJ) | 80109..80708 | + | 600 | WP_006485335.1 | type VI secretion system lipoprotein TssJ |
| T6CP015869 | TssK | WQ49_RS11840 (tssK) | 80814..82160 | + | 1347 | WP_006477098.1 | type VI secretion system baseplate subunit TssK |
| T6CP015870 | TssL | WQ49_RS11845 | 82157..82939 | + | 783 | WP_006491869.1 | type IVB secretion system protein IcmH/DotU |
| WQ49_RS11850 | 83053..83388 | - | 336 | WP_006485334.1 | hypothetical protein | ||
| WQ49_RS11855 | 83470..83787 | - | 318 | WP_006485338.1 | hypothetical protein | ||
| WQ49_RS11860 | 84069..84869 | + | 801 | WP_006485337.1 | transporter substrate-binding domain-containing protein | ||
| WQ49_RS11865 | 84979..85182 | - | 204 | WP_006485326.1 | hypothetical protein | ||
| WQ49_RS11875 | 85631..86152 | - | 522 | WP_006485328.1 | ClpXP protease specificity-enhancing factor | ||
| WQ49_RS11880 | 86224..86835 | - | 612 | WP_006400565.1 | glutathione S-transferase N-terminal domain-containing protein | ||
| WQ49_RS11885 | 86930..87688 | - | 759 | WP_006477108.1 | cytochrome c1 |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed. Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01849 |
WQ49_11820 (hcp) | - | - | Burkholderia cenocepacia strain K56-2 scf7180000000051 | chromosome (NZ_LAUA01000004) | 76454..76957 (-) | 493523014 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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