Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00941  |
| T6SS type | Type Unknown |
| Strain | Escherichia coli strain STEC004 |
| Replicon (GenBank) | chromosome I (KX118288) |
| Location | 1..7947 |
| Function | anti-bacterial |
| Comment | E. coli STEC004 cells deploy Rhs-CT1 to inhibit neighboring cells and protect themselves with the corresponding immunity protein CTI1. |
| References | [1] Ma J, Sun M, Dong W, Pan Z, Lu C, Yao H et al (2017) PAAR-Rhs proteins harbor various C-terminal toxins to diversify the antibacterial pathways of type VI secretion systems. Environ Microbiol. (1):345-360. [PudMed:27871130] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | Ct1A | Ct1B | Ct1C | Ct1D | Ct1E |
| Number | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| T6CP016141 | Ct1A | Locus_01 (ct1A) | 1..1902 | + | 1902 | 1062685105 | orphan Vgr family protein |
| T6CP016142 | Ct1B | Locus_02 (ct1B) | 1930..2391 | + | 462 | 1062685106 | DUF1795 protein |
| T6CP016143 | Ct1C | Locus_03 (ct1C) | 2411..7273 | + | 4863 | 1062685107 | Rhs core protein |
| T6CP016144 | Ct1D | Locus_04 (ct1D) | 7270..7521 | + | 252 | 1062685108 | immunity protein of metallopeptidase 4 toxin |
| T6CP016145 | Ct1E | Locus_05 (ct1E) | 7636..7947 | + | 312 | 1062685109 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01520 |
AAF13_24950 (Hcp-ET1) | Tde | IMU00344 |
Escherichia coli strain STEC004 | chromosome (NZ_CP011331) | 4965377..4966555 (-) | 445988041 |
| EFF01518 |
ct1C (Rhs-CT1) | Tpe | IMU00321 |
Escherichia coli strain STEC004 | chromosome (KX118288) | 2411..7273 (+) | 1062685107 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00321 |
AOM81336 (CTI1) | EFF01518 |
Escherichia coli strain STEC004 | chromosome (KX118288) | 7270..7521 (+) | 1062685108 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| ACP00038 |
AOM81334 (eagR/DUF1795) | adaptor | Escherichia coli strain STEC004 | chromosome (KX118288) | 1930..2391 (+) | 1062685106 | ct1A (VgrGO1) | ct1C (Rhs-CT1) |