Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01046  |
| T6SS type | Type i4b |
| Strain | Acinetobacter baumannii ATCC 17978 |
| Replicon (RefSeq) | chromosome (NZ_CP012004) |
| Location | 2433628..2461317 |
| Function | anti-bacterial |
| Comment | - |
| References | [1] Weber BS, Hennon SW, Wright MS, Scott NE, de Berardinis V, Foster LJ, Ayala JA, Adams MD, Feldman MF. et al (2016) Genetic Dissection of the Type VI Secretion System in Acinetobacter and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis.. mBio. 7(5). [PudMed:27729508] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| ACX60_RS11575 | 2428702..2429880 | - | 1179 | WP_000813819.1 | cyanate transporter | ||
| ACX60_RS11580 | 2429880..2430362 | - | 483 | WP_000646735.1 | nucleoside deaminase | ||
| ACX60_RS11585 | 2430378..2431046 | - | 669 | WP_001232205.1 | ankyrin repeat domain-containing protein | ||
| ACX60_RS11590 | 2431198..2432049 | + | 852 | WP_000460184.1 | LysR family transcriptional regulator | ||
| ACX60_RS11595 | 2432052..2433005 | - | 954 | WP_000972583.1 | M15 family metallopeptidase | ||
| ACX60_RS11600 | 2433013..2433615 | - | 603 | WP_000046446.1 | hypothetical protein | ||
| T6CP013542 | TssL | ACX60_RS11605 (icmH) | 2433628..2434434 | - | 807 | WP_000083629.1 | type IVB secretion system protein IcmH/DotU |
| T6CP013543 | TssK | ACX60_RS11610 (tssK) | 2434452..2435816 | - | 1365 | WP_000471450.1 | type VI secretion system baseplate subunit TssK |
| T6CP013544 | TssA | ACX60_RS11615 (tssA) | 2435833..2436930 | - | 1098 | WP_000020712.1 | type VI secretion system protein TssA |
| T6CP013545 | TssH | ACX60_RS11620 (tssH) | 2436954..2439635 | - | 2682 | WP_109426774.1 | type VI secretion system ATPase TssH |
| ACX60_RS11625 | 2439855..2440118 | - | 264 | WP_000168111.1 | PAAR domain-containing protein | ||
| ACX60_RS11630 | 2440135..2440902 | - | 768 | WP_001072403.1 | OmpA family protein | ||
| ACX60_RS11635 (tagF) | 2440905..2441864 | - | 960 | WP_000557241.1 | type VI secretion system-associated protein TagF | ||
| T6CP013546 | TssM | ACX60_RS11640 (tssM) | 2441902..2445726 | - | 3825 | WP_049594841.1 | type VI secretion system membrane subunit TssM |
| ACX60_RS11645 | 2445757..2447169 | - | 1413 | WP_000591878.1 | hypothetical protein | ||
| T6CP013547 | TssG | ACX60_RS11650 (tssG) | 2447166..2448164 | - | 999 | WP_000555491.1 | type VI secretion system baseplate subunit TssG |
| T6CP013548 | TssF | ACX60_RS11655 (tssF) | 2448128..2449939 | - | 1812 | WP_049594842.1 | type VI secretion system baseplate subunit TssF |
| T6CP013549 | TssE | ACX60_RS11660 (tssE) | 2449956..2450432 | - | 477 | WP_001047031.1 | type VI secretion system baseplate subunit TssE |
| T6CP013550 | TssD | ACX60_RS11665 | 2450512..2451015 | - | 504 | WP_000653195.1 | type VI secretion system tube protein Hcp |
| T6CP013551 | TssC | ACX60_RS11670 (tssC) | 2451065..2452546 | - | 1482 | WP_001066525.1 | type VI secretion system contractile sheath large subunit |
| T6CP013552 | TssB | ACX60_RS11675 (tssB) | 2452539..2453042 | - | 504 | WP_001119042.1 | type VI secretion system contractile sheath small subunit |
| ACX60_RS11680 | 2453059..2453751 | - | 693 | WP_000869709.1 | hypothetical protein | ||
| ACX60_RS11685 | 2454523..2455491 | + | 969 | WP_032046197.1 | SUMF1/EgtB/PvdO family nonheme iron enzyme | ||
| ACX60_RS11690 | 2455521..2458526 | - | 3006 | WP_001070510.1 | hypothetical protein | ||
| T6CP013553 | TssI | ACX60_RS11695 | 2458534..2461317 | - | 2784 | WP_049594843.1 | type VI secretion system tip protein VgrG |
| ACX60_RS11700 | 2461463..2461864 | + | 402 | WP_000043355.1 | hypothetical protein | ||
| ACX60_RS11705 | 2461960..2462904 | + | 945 | WP_005135439.1 | ABC transporter permease | ||
| ACX60_RS11710 | 2462904..2463785 | + | 882 | WP_001000081.1 | ABC transporter ATP-binding protein | ||
| ACX60_RS11715 | 2463837..2464859 | - | 1023 | WP_000591168.1 | ABC transporter substrate-binding protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0370 |
ACX60_RS11355 (racK) | protein | Environmental signal | Acinetobacter baumannii strain ATCC 17978 | chromosome (NZ_CP012004) | 2382673..2383965 (+) | WP_000769882.1 | ACX60_RS00605 (Tse4) (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01804 |
ACX60_15365 (tse2) | Tde | IMU00346 |
Acinetobacter baumannii strain ATCC 17978 | chromosome (NZ_CP012004) | 3246173..3247762 (-) | 447036044 |
| EFF01806 |
ACX60_11695 (tse3) | Tse | IMU38221 |
Acinetobacter baumannii strain ATCC 17978 | chromosome (NZ_CP012004) | 2455521..2458526 (-) | 446993254 |
| EFF01805 |
ACX60_11670 (hcp) | - | - | Acinetobacter baumannii strain ATCC 17978 | chromosome (NZ_CP012004) | 2450512..2451015 (-) | 446575849 |
| EFF76634 |
ACX60_00605 (Tse4) | Tpe/Tge | IMU38209 |
Acinetobacter baumannii strain ATCC 17978 | chromosome (NZ_CP012004) | 131270..133708 (+) | WP_049594793.1 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00346 |
ACX60_15360 (Tdi) | EFF01804 |
Acinetobacter baumannii strain ATCC 17978 | chromosome (NZ_CP012004) | 3245298..3246158 (-) | 884901468 |
| IMU38209 |
ACX60_00605 (tsi4) | EFF76634 |
Acinetobacter baumannii strain ATCC 17978 | chromosome (NZ_CP012004) | 133713..134519 (+) | WP_000598979.1 |
| IMU38221 |
ACX60_11690 (tsi3) | EFF01806 |
Acinetobacter baumannii strain ATCC 17978 | chromosome (NZ_CP012004) | 2454523..2455491 (+) | WP_032046197.1 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| ACP00039 |
ACX60_11600 (tagX) | structure affiliated protein | Acinetobacter baumannii strain ATCC 17978 | chromosome (NZ_CP012004) | 2432052..2433005 (-) | 446895327 | - | peptidoglycan |