SecReT6, T6SS database

Detailed information of effector

Summary

Effector ID	EFF01805
Effector type	-
Cognate immunity protein	-
Related T6SS (Type)	T6SS01046 (Type i4b)
Strain	Acinetobacter baumannii strain ATCC 17978
Replicon	chromosome
Sequence	Protein sequence (168 a.a.); Nucleotide sequence (504 bp)
Description	hcp
Reference	[1] Weber BS, Hennon SW, Wright MS, et al. Genetic Dissection of the Type VI Secretion System in Acinetobacter and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis. mBio. 2016 Oct 11;7(5). pii: e01253-16. doi: 10.1128/mBio.01253-16. PMID: 27729508 [2] Lopez J, Ly PM, Feldman MF. The Tip of the VgrG Spike Is Essential to Functional Type VI Secretion System Assembly in Acinetobacter baumannii. mBio. 2020 Jan 14;11(1). pii: e02761-19. doi: 10.1128/mBio.02761-19. PMID: 31937641

Experimental investigation has been performed.

Bioinformatics investigation has been performed

External database links

Locus tag (Gene)	ACX60_11670 (hcp)
Coordinates (Strand)	2450512..2451015 (-)
NCBI ID	446575849
RefSeq	NZ_CP012004
Uniprot ID	A0A0R1C1Y7_ACINO, A0A009RJK0_9GAMM, A0A010KAB5_9GAMM, A0A013UTK5_9GAMM, A0A013TMC1_9GAMM, A0A0E1PSF3_ACIBA, A0A0J0ZX19_ACIBA, N8S3X6_9GAMM, A0A1V2V3D7_9GAMM, A0A1A0GM72_ACICA, A0A143IYH8_ACIPI, B0VB03_ACIBY, D0C8P3_ACIB2, F0KJP8_ACICP, L9MI81_9GAMM
KEGG ID	acc:BDGL_000641, aby:ABAYE2413
PDB ID	-

Pfam domain hit(s)

Domain	Pfam ID	E-value	Aligned region
T6SS_HCP	PF05638.14	5.4e-40	5..139

Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-167	MKDIYVEFRGKYKVDGESRDSEHKGWLEVNSWSHNIRQPKSATSSSVGGHTAERVEHSDMVFVKDLDATSPKLWEACSAGYTFDEVQIDFYRANGDKRIKYLQIKLKHVLVSSVTPTVNEEGVPTEAFGLKYAAVEWTYNQQDINGTAKGAVTKKWSLSNNTASYAA

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9825	-	-

Protein sequence: 168 a.a. .

                                    >EFF01805 NZ_CP012004:c2451015-2450512  (Unknown) [Acinetobacter baumannii]
MKDIYVEFRGKYKVDGESRDSEHKGWLEVNSWSHNIRQPKSATSSSVGGHTAERVEHSDMVFVKDLDATSPKLWEACSAG
YTFDEVQIDFYRANGDKRIKYLQIKLKHVLVSSVTPTVNEEGVPTEAFGLKYAAVEWTYNQQDINGTAKGAVTKKWSLSN
NTASYAA*

                                

Nucleotide sequence: 504 bp .

                                    >EFF01805 NZ_CP012004:c2451015-2450512  (Unknown) [Acinetobacter baumannii]
ATGAAAGATATATACGTTGAGTTTCGCGGTAAATATAAAGTTGATGGAGAATCTCGTGATTCTGAGCACAAAGGTTGGTT
AGAAGTTAACTCTTGGTCTCATAACATCCGTCAACCTAAATCTGCTACTTCAAGTAGTGTAGGCGGCCACACTGCTGAAC
GTGTTGAACATTCTGACATGGTTTTCGTAAAAGACTTAGATGCAACTAGCCCTAAATTATGGGAAGCTTGTTCAGCTGGT
TATACATTTGATGAAGTACAAATCGACTTCTATCGTGCAAATGGCGATAAACGTATCAAGTACTTACAAATCAAATTGAA
GCACGTTTTAGTTTCTAGTGTGACTCCAACTGTTAACGAAGAAGGCGTTCCTACAGAAGCATTCGGTTTGAAATATGCTG
CTGTTGAGTGGACTTATAACCAACAAGATATTAACGGTACTGCTAAAGGTGCTGTTACTAAGAAATGGTCACTTTCTAAT
AATACAGCTTCTTACGCAGCGTAA

                                