Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


T6SS ID T6SS00126 experimental
T6SS type Type i4b
Strain Burkholderia cenocepacia AU 1054
Replicon (RefSeq) chromosome I (NC_008060)
Location 2880426..2919827
Function anti-bacterial; anti-eukaryotic
Comment T6SS effector TecA of B. cenocepacia exacerbates inflammatory cell recruitment and weight loss and is required for lethality, acts as a key virulence factor during lung infection.
[1] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603]
[2] Perault AI, Chandler CE, Rasko DA, Ernst RK, Wolfgang MC, Cotter PA. et al (2020) Host Adaptation Predisposes Pseudomonas aeruginosa to Type VI Secretion System-Mediated Predation by the Burkholderia cepacia Complex.. Cell Host Microbe. 28(4):534-547. [PudMed:32755549]
[3] Loeven NA, Perault AI, Cotter PA, Hodges CA, Schwartzman JD, Hampton TH, Bliska JB. et al (2021) The Burkholderia cenocepacia Type VI Secretion System Effector TecA Is a Virulence Factor in Mouse Models of Lung Infection.. mBio. 12(5):e0209821. [PudMed:34579569]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
BCEN_RS13040 2875714..2876691 + 978 WP_011694129.1 zinc-binding alcohol dehydrogenase family protein
BCEN_RS33185 2876716..2876868 + 153 WP_011694128.1 DUF1427 family protein
BCEN_RS13045 2876912..2877940 - 1029 WP_011546564.1 transporter
BCEN_RS13050 2878153..2879157 - 1005 WP_011546565.1 hypothetical protein
BCEN_RS13055 2879279..2880124 + 846 WP_011546566.1 M15 family metallopeptidase
T6CP001216 TssM BCEN_RS13060 (tssM) 2880426..2884370 + 3945 WP_011546567.1 type VI secretion system membrane subunit TssM
BCEN_RS13065 (tagF) 2884367..2885356 + 990 WP_006477085.1 type VI secretion system-associated protein TagF
BCEN_RS13070 2885365..2886309 + 945 WP_050768801.1 OmpA family protein
BCEN_RS13075 2886577..2887197 - 621 WP_011546569.1 hypothetical protein
BCEN_RS13080 2887230..2888099 - 870 WP_011546570.1 hypothetical protein
BCEN_RS13085 2888210..2888533 + 324 pseudogene OmpA family protein
BCEN_RS13090 2888616..2890877 - 2262 WP_011546572.1 DUF2235 domain-containing protein
BCEN_RS13095 2890864..2891784 - 921 WP_175810064.1 hypothetical protein
BCEN_RS34670 2891777..2891986 - 210 WP_041489595.1 hypothetical protein
BCEN_RS13100 2892019..2892774 - 756 WP_166488154.1 hypothetical protein
BCEN_RS13105 2892842..2893882 - 1041 WP_011546575.1 DUF4123 domain-containing protein
BCEN_RS13110 2893882..2896447 - 2566 pseudogene type VI secretion system tip protein VgrG
T6CP001218 TssA BCEN_RS13115 (tssA) 2896514..2897635 - 1122 WP_011546577.1 type VI secretion system protein TssA
T6CP011511 TssH BCEN_RS13120 (tssH) 2897679..2900346 - 2668 pseudogene type VI secretion system ATPase TssH
T6CP001220 TssG BCEN_RS13125 (tssG) 2900388..2901488 - 1101 WP_011694123.1 type VI secretion system baseplate subunit TssG
T6CP001221 TssF BCEN_RS13130 (tssF) 2901452..2903287 - 1836 WP_006477091.1 type VI secretion system baseplate subunit TssF
T6CP001222 TssE BCEN_RS13135 (tssE) 2903364..2903849 - 486 WP_006477092.1 type VI secretion system baseplate subunit TssE
T6CP001223 TssD BCEN_RS13140 2903912..2904415 - 504 WP_006477093.1 type VI secretion system tube protein Hcp
T6CP001224 TssC BCEN_RS13145 (tssC) 2904486..2905976 - 1491 WP_006477094.1 type VI secretion system contractile sheath large subunit
T6CP001225 TssB BCEN_RS13150 (tssB) 2905992..2906507 - 516 WP_006484395.1 type VI secretion system contractile sheath small subunit
BCEN_RS13155 2906554..2907189 - 636 WP_011546581.1 tetratricopeptide repeat protein
T6CP001226 TssJ BCEN_RS13160 (tssJ) 2907562..2908173 + 612 WP_006477097.1 type VI secretion system lipoprotein TssJ
T6CP001227 TssK BCEN_RS13165 (tssK) 2908276..2909622 + 1347 WP_006477098.1 type VI secretion system baseplate subunit TssK
T6CP001228 TssL BCEN_RS13170 (icmH) 2909619..2910401 + 783 WP_011546582.1 type IVB secretion system protein IcmH/DotU
BCEN_RS13175 2910488..2910805 - 318 WP_011546583.1 hypothetical protein
BCEN_RS33190 2911341..2911916 - 576 WP_011546584.1 hypothetical protein
BCEN_RS13180 2911927..2916584 - 4658 pseudogene RHS domain-containing protein
T6CP001229 TssI BCEN_RS13185 2916636..2919827 - 3192 WP_011546587.1 type VI secretion system tip protein VgrG
BCEN_RS13190 2920184..2920984 + 801 WP_011546588.1 transporter substrate-binding domain-containing protein
BCEN_RS13195 2921094..2921297 - 204 WP_011546589.1 hypothetical protein
BCEN_RS13200 2922015..2922966 - 952 pseudogene sce7725 family protein
BCEN_RS33195 2923030..2923914 - 885 WP_011546591.1 sce7726 family protein
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector