Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00551  |
| T6SS type | Type i3 |
| Strain | Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S |
| Replicon (RefSeq) | chromosome (NC_016856) |
| Location | 305365..332747 |
| Function | anti-eukaryotic; virulence |
| Comment | Required for full virulence in mice; gastrointestinal colonization and systemic spread of Salmonella enterica serovar Typhimurium in the chicken. |
| References | [1] Liu J et al (2012) The type VI secretion system gene cluster of Salmonella typhimurium: required for full virulence in mice. J Basic Microbiol. 53(7):600-7. [PudMed:22961625] [2] Pezoa D et al (2013) The Type VI Secretion System Encoded in SPI-6 Plays a Role in Gastrointestinal Colonization and Systemic Spread of Salmonella enterica serovar Typhimurium in the Chicken. PLoS One. 8(5):e63917. [PudMed:23691117] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagJ | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| STM14_RS01885 (mltD) | 300623..301990 | - | 1368 | WP_000644706.1 | murein transglycosylase D | ||
| STM14_RS01890 (gloB) | 302062..302817 | - | 756 | WP_001052775.1 | hydroxyacylglutathione hydrolase | ||
| STM14_RS01895 | 302852..303574 | + | 723 | WP_000801238.1 | class I SAM-dependent methyltransferase | ||
| STM14_RS01900 (rnhA) | 303571..304038 | - | 468 | WP_000917872.1 | ribonuclease HI | ||
| STM14_RS01905 (dnaQ) | 304102..304833 | + | 732 | WP_001670675.1 | DNA polymerase III subunit epsilon | ||
| T6CP005827 | TssA | STM14_RS01915 | 305365..306420 | - | 1056 | WP_000367626.1 | ImpA family type VI secretion system protein |
| T6CP005828 | TssG | STM14_RS01920 (tssG) | 306431..307426 | - | 996 | WP_000145244.1 | type VI secretion system baseplate subunit TssG |
| T6CP005829 | TssF | STM14_RS01925 (tssF) | 307423..309306 | - | 1884 | WP_000371510.1 | type VI secretion system baseplate subunit TssF |
| T6CP005830 | TssE | STM14_RS01930 (tssE) | 309322..309816 | - | 495 | WP_000108007.1 | type VI secretion system baseplate subunit TssE |
| T6CP012825 | TagJ | STM14_RS01935 | 309813..310637 | - | 825 | WP_000750535.1 | hypothetical protein |
| STM14_RS01940 (tagK) | 310624..311526 | - | 903 | WP_000806681.1 | type VI secretion system-associated protein TagK | ||
| T6CP005831 | TssH | STM14_RS01950 (tssH) | 311894..314533 | + | 2640 | WP_000449778.1 | type VI secretion system ATPase TssH |
| T6CP005832 | TssB | STM14_RS01955 (tssB) | 314633..315175 | + | 543 | WP_000996817.1 | type VI secretion system contractile sheath small subunit |
| T6CP005833 | TssC | STM14_RS01960 (tssC) | 315199..316692 | + | 1494 | WP_000013879.1 | type VI secretion system contractile sheath large subunit |
| STM14_RS25840 | 316758..316865 | + | 108 | pseudogene | BPSL0067 family protein | ||
| STM14_RS01965 | 316992..317324 | + | 333 | WP_014344502.1 | hypothetical protein | ||
| T6CP005834 | TssD | STM14_RS01970 | 317578..318063 | + | 486 | WP_000312802.1 | Hcp family type VI secretion system effector |
| STM14_RS26610 | 318083..318238 | + | 156 | WP_001541860.1 | hypothetical protein | ||
| STM14_RS01975 | 318368..318853 | + | 486 | WP_001081550.1 | type VI secretion system amidase effector protein Tae4 | ||
| STM14_RS01980 | 318838..319221 | + | 384 | WP_000379146.1 | type VI secretion system amidase immunity protein Tai4 | ||
| T6CP005835 | TssD | STM14_RS01985 | 319364..319849 | + | 486 | WP_000119443.1 | Hcp family type VI secretion system effector |
| T6CP005836 | TssJ | STM14_RS01990 (tssJ) | 319916..320452 | + | 537 | WP_001007106.1 | type VI secretion system lipoprotein TssJ |
| T6CP005837 | TssK | STM14_RS01995 (tssK) | 320456..321799 | + | 1344 | WP_000118732.1 | type VI secretion system baseplate subunit TssK |
| T6CP005838 | TssL | STM14_RS02000 (tssL) | 321796..323100 | + | 1305 | WP_000132483.1 | type VI secretion system protein TssL, long form |
| STM14_RS02005 | 323105..323878 | + | 774 | WP_000976553.1 | membrane protein | ||
| STM14_RS02010 | 324081..324512 | + | 432 | WP_000227044.1 | Shiga toxin A subunit | ||
| T6CP005839 | TssM | STM14_RS02015 (tssM) | 324546..328415 | + | 3870 | WP_001168961.1 | type VI secretion system membrane subunit TssM |
| STM14_RS02020 | 328415..329203 | + | 789 | WP_001254137.1 | DUF2094 domain-containing protein | ||
| STM14_RS02025 | 329200..329616 | + | 417 | WP_001596567.1 | DUF2195 family protein | ||
| STM14_RS02030 | 329640..330161 | + | 522 | WP_000968384.1 | DUF2778 domain-containing protein | ||
| T6CP005840 | TssI | STM14_RS02035 | 330558..332747 | + | 2190 | WP_000011535.1 | type VI secretion system Vgr family protein |
| STM14_RS02040 | 332771..333217 | + | 447 | WP_000375832.1 | DcrB-related protein | ||
| T6CP011991 | PAAR | STM14_RS02045 | 333236..337330 | + | 4095 | WP_000272656.1 | PAAR domain-containing protein |
| STM14_RS02050 | 337324..337587 | + | 264 | WP_000932531.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01810 |
STM14_0336 (Tlde1) | Tde | - | Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S | chromosome (NC_016856) | 329640..330161 (+) | 446891128 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00372 |
STM14_0335 (Tldi1) | - | Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S | chromosome (NC_016856) | 329200..329616 (+) | 267991976 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|