SecReT6, T6SS database

Detailed information of component protein

Summary

Component ID	T6CP005833
Component protein type	TssC
T6SS ID (Type)	T6SS00551 (Type i3)
Strain	Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S
Replicon	chromosome
Sequence	Protein sequence (498 a.a.); Nucleotide sequence (1494 bp)
Reference	[1] Liu J, Guo JT, Li YG, et al. The type VI secretion system gene cluster of Salmonella typhimurium: required for full virulence in mice. J Basic Microbiol. 2013 Jul;53(7):600-7. doi: 10.1002/jobm.201200047. Epub 2012 Sep 7. PMID: 22961625 [2] Pezoa D, Yang HJ, Blondel CJ, et al. The type VI secretion system encoded in SPI-6 plays a role in gastrointestinal colonization and systemic spread of Salmonella enterica serovar Typhimurium in the chicken. PLoS One. 2013 May 14;8(5):e63917. doi: 10.1371/journal.pone.0063917. Print 2013. PMID: 23691117

Experimental investigation has been performed on this T6SS

External database links

Locus tag (Gene)	STM14_RS01960
Coordinate (Strand)	315199..316692 (+)
NCBI ID	WP_000013879.1
RefSeq	NC_016856
Uniprot ID	A0A0H3N8D7_SALTS, A0A4P7XNM0_SALET, A0A622F737_SALER, A0A601HY80_SALET, A0A5Z8QRP4_SALET, A0A6C7I8C9_SALTD, A0A0F6AX75_SALT1, A0A3U4NHA4_SALET, Q93IS7_SALTM, E8XIT8_SALT4, A0A6C7AJ70_SALTU
KEGG ID	seo:STM14_0321, sev:STMMW_02741, seb:STM474_0285, sey:SL1344_0268, sej:STMUK_0276
PDB ID	-

Pfam domain hit(s)

Domain	Pfam ID	E-value	Aligned region
VipB	PF05943.14	4.9e-132	65..368
VipB_2	PF18945.2	2.4e-44	378..489

Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-497	MANSNMQATDAVAQDTASASGEFDALLNQAFRPKTTQAAKAVEAAVQTLANTITVSDDAYKSISAIIAQIDFKLTEQIKLILQHPDWQKLESSWRGMEHLVYNTETDEKLKIRFMNLSKDELRRNMKRYKGIAWDQSPMFKKLYEAEYGQLGGEPYGCIIADYYFDHTPPDVDLLGSIAKVAASAHAPFIAGASPSVLQMDSWQELANPRDLTKIVTQNLEYAPWNSLRASEDSRYIGLTMPRFLARLPYGAKTNPVDEFDFEEDADGSDHTKYVWSNAAYAMGVNINRSFKHYGWCTLIRGVESGGAVENLPCHTFPTDDGGVDMKCPTEIAISDRREAELAKNGFIPLIHRKNSDYAAFIGAQSLQKPQEYYDPDATANANLSARLPYLFACSRFAHFLKCIVRDKIGSFKEREDMQRWLNEWIMNYVDADPVNSSQETKARRPLAAAEVVVEEVEGNPGYYDAKFFLRPHFQLEGLTGSLRLVTKLPSVKQGNA

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9577	-	-

Protein sequence: 498 a.a.

						>T6CP005833 NC_016856:315199-316692 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S] [TssC]
MANSNMQATDAVAQDTASASGEFDALLNQAFRPKTTQAAKAVEAAVQTLANTITVSDDAYKSISAIIAQIDFKLTEQIKL
ILQHPDWQKLESSWRGMEHLVYNTETDEKLKIRFMNLSKDELRRNMKRYKGIAWDQSPMFKKLYEAEYGQLGGEPYGCII
ADYYFDHTPPDVDLLGSIAKVAASAHAPFIAGASPSVLQMDSWQELANPRDLTKIVTQNLEYAPWNSLRASEDSRYIGLT
MPRFLARLPYGAKTNPVDEFDFEEDADGSDHTKYVWSNAAYAMGVNINRSFKHYGWCTLIRGVESGGAVENLPCHTFPTD
DGGVDMKCPTEIAISDRREAELAKNGFIPLIHRKNSDYAAFIGAQSLQKPQEYYDPDATANANLSARLPYLFACSRFAHF
LKCIVRDKIGSFKEREDMQRWLNEWIMNYVDADPVNSSQETKARRPLAAAEVVVEEVEGNPGYYDAKFFLRPHFQLEGLT
GSLRLVTKLPSVKQGNA*					

Nucleotide sequence: 1494 bp

						>T6CP005833 NC_016856:315199-316692 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S] [TssC]
ATGGCAAACAGTAATATGCAGGCAACCGACGCGGTTGCTCAGGATACCGCCTCCGCATCCGGTGAATTTGATGCGTTGCT
GAATCAGGCCTTCCGACCCAAGACTACCCAGGCGGCAAAAGCCGTGGAAGCCGCGGTGCAGACGCTGGCGAACACGATCA
CCGTCAGCGATGACGCCTATAAAAGCATCAGCGCTATTATTGCGCAGATCGACTTTAAACTGACCGAACAGATCAAACTG
ATCCTGCAACATCCCGACTGGCAGAAGCTGGAATCCTCGTGGCGCGGTATGGAGCATCTGGTTTACAACACCGAGACCGA
CGAAAAGCTGAAAATTCGCTTCATGAATCTGTCAAAAGATGAATTGCGGCGCAACATGAAGCGTTACAAGGGCATCGCCT
GGGATCAAAGCCCGATGTTCAAGAAACTGTATGAAGCCGAATACGGCCAGTTAGGTGGCGAACCTTATGGCTGTATCATT
GCGGATTACTACTTCGACCATACACCGCCCGATGTGGATCTGCTTGGCTCTATCGCCAAAGTCGCCGCGTCGGCCCATGC
GCCGTTTATTGCCGGGGCTTCCCCCTCGGTACTGCAAATGGACTCCTGGCAGGAACTGGCGAATCCCCGCGACCTGACCA
AAATCGTCACCCAGAACCTGGAATATGCGCCGTGGAACTCGCTGCGGGCTAGCGAAGACTCCCGTTATATTGGCCTGACG
ATGCCGCGTTTTCTTGCCCGCCTGCCGTATGGCGCAAAAACCAACCCGGTGGACGAGTTTGATTTTGAAGAAGATGCGGA
TGGTTCTGACCATACCAAATACGTCTGGAGCAACGCGGCCTACGCGATGGGCGTAAACATCAACCGTTCCTTCAAACACT
ACGGCTGGTGTACGTTGATTCGCGGTGTGGAATCAGGCGGTGCGGTGGAAAATCTTCCCTGCCATACCTTCCCGACTGAC
GATGGCGGCGTGGACATGAAATGCCCGACCGAAATCGCCATCTCTGACCGCCGCGAGGCTGAACTGGCGAAAAACGGTTT
TATCCCGTTGATCCACCGTAAAAACTCAGACTATGCCGCCTTTATCGGCGCACAGTCGCTGCAAAAACCACAGGAATACT
ACGATCCGGACGCGACGGCCAACGCTAACCTGTCTGCCCGTCTACCGTACCTGTTCGCCTGCTCGCGCTTCGCTCACTTC
CTCAAATGTATCGTCCGCGACAAAATCGGTTCCTTTAAAGAGCGTGAGGATATGCAGCGCTGGCTAAATGAATGGATTAT
GAATTATGTCGACGCCGATCCGGTGAACTCCTCGCAAGAAACTAAAGCCCGTCGTCCGCTGGCTGCCGCTGAAGTAGTGG
TGGAAGAGGTCGAAGGCAATCCAGGTTATTACGACGCGAAATTCTTCCTGCGTCCGCATTTCCAGCTTGAAGGGCTGACG
GGATCGCTGCGCCTGGTGACAAAACTGCCGTCAGTGAAGCAGGGCAATGCCTGA					