Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00382  |
| T6SS type | Type i3 |
| Strain | Xenorhabdus bovienii SS-2004 |
| Replicon (RefSeq) | chromosome (NC_013892) |
| Location | 2053604..2079234 |
| Function | anti-bacterial |
| Comment | The hcp1 mutant was unable to kill the prey on solid media, and this defect can be complemented by introducing hcp1 on a plasmid. T6SS-1 and T6SS-2 facilitated biofilm formation in XBJ. |
| References | [1] Kochanowsky RM, Bradshaw C, Forlastro I, Stock SP. et al (2020) Xenorhabdus bovienii strain jolietti uses a type 6 secretion system to kill closely related Xenorhabdus strains.. FEMS Microbiol Ecol. 96(8). [PudMed:32558899] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| XBJ1_RS08870 | 2048626..2049093 | + | 468 | WP_143827653.1 | hypothetical protein | ||
| XBJ1_RS08875 | 2049240..2049680 | + | 441 | WP_012988541.1 | GNAT family N-acetyltransferase | ||
| XBJ1_RS08880 | 2049932..2050144 | - | 213 | WP_012988543.1 | hypothetical protein | ||
| XBJ1_RS20755 | 2050346..2051040 | - | 695 | WP_143827612.1 | IS1 family transposase | ||
| XBJ1_RS08890 | 2051099..2051299 | - | 201 | pseudogene | photopexin B | ||
| XBJ1_RS19795 | 2051533..2051783 | + | 251 | pseudogene | helix-turn-helix domain-containing protein | ||
| XBJ1_RS08900 | 2051865..2052560 | + | 696 | WP_012988546.1 | IS6 family transposase | ||
| XBJ1_RS08905 | 2052635..2053363 | - | 729 | WP_012988547.1 | hypothetical protein | ||
| T6CP003911 | TssH | XBJ1_RS08910 (tssH) | 2053604..2056237 | - | 2634 | WP_012988548.1 | type VI secretion system ATPase TssH |
| T6CP003912 | TssG | XBJ1_RS08915 (tssG) | 2056281..2057357 | - | 1077 | WP_012988549.1 | type VI secretion system baseplate subunit TssG |
| T6CP003913 | TssF | XBJ1_RS08920 (tssF) | 2057415..2059289 | - | 1875 | WP_012988550.1 | type VI secretion system baseplate subunit TssF |
| T6CP003914 | TssE | XBJ1_RS08925 | 2059309..2059863 | - | 555 | WP_012988551.1 | GPW/gp25 family protein |
| T6CP011809 | FHA | XBJ1_RS08930 (tagH) | 2059923..2061479 | - | 1557 | WP_038198787.1 | type VI secretion system-associated FHA domain protein TagH |
| T6CP009381 | TssD | XBJ1_RS08935 | 2061568..2062071 | - | 504 | WP_012988553.1 | type VI secretion system tube protein Hcp |
| T6CP003915 | TssC | XBJ1_RS08940 (tssC) | 2062237..2063739 | - | 1503 | WP_012988554.1 | type VI secretion system contractile sheath large subunit |
| T6CP003916 | TssB | XBJ1_RS08945 (tssB) | 2063743..2064294 | - | 552 | WP_012988555.1 | type VI secretion system contractile sheath small subunit |
| T6CP003917 | TssA | XBJ1_RS08950 (tssA) | 2064485..2065540 | - | 1056 | WP_012988556.1 | type VI secretion system protein TssA |
| T6CP003918 | TssM | XBJ1_RS08955 (tssM) | 2065703..2069218 | - | 3516 | WP_012988557.1 | type VI secretion system membrane subunit TssM |
| T6CP003919 | TssL | XBJ1_RS08960 | 2069231..2070442 | - | 1212 | WP_012988558.1 | DotU family type VI secretion system protein |
| T6CP003920 | TssK | XBJ1_RS08965 (tssK) | 2070486..2071829 | - | 1344 | WP_012988559.1 | type VI secretion system baseplate subunit TssK |
| T6CP003921 | TssJ | XBJ1_RS08970 (tssJ) | 2071856..2072368 | - | 513 | WP_143827727.1 | type VI secretion system lipoprotein TssJ |
| XBJ1_RS08975 | 2072520..2072921 | - | 402 | WP_012988562.1 | DUF4150 domain-containing protein | ||
| XBJ1_RS08980 | 2072942..2073604 | - | 663 | WP_012988563.1 | DUF3540 domain-containing protein | ||
| XBJ1_RS08985 | 2073619..2074692 | - | 1074 | WP_012988564.1 | pentapeptide repeat-containing protein | ||
| XBJ1_RS08990 | 2074689..2077283 | - | 2595 | WP_012988565.1 | DUF2169 domain-containing protein | ||
| T6CP003922 | TssI | XBJ1_RS08995 (tssI) | 2077318..2079174 | - | 1857 | WP_158304286.1 | type VI secretion system tip protein VgrG |
| XBJ1_RS22010 | 2080030..2080165 | - | 136 | pseudogene | IS5/IS1182 family transposase | ||
| XBJ1_RS09000 | 2080593..2081126 | + | 534 | WP_038198792.1 | hypothetical protein | ||
| XBJ1_RS09005 | 2081723..2082508 | + | 786 | WP_143827654.1 | thioesterase II family protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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