Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01294  |
| T6SS type | Type i3 |
| Strain | Burkholderia pseudomallei K96243 |
| Replicon (GenBank) | chromosome II (CP009537) |
| Location | 2018346..2040803 |
| Function | - |
| Comment | The LD50 values for the Δhcp2 through Δhcp6 mutants were indistinguishable from that of the wild type, suggesting that T6SS-2, T6SS-3, T6SS-4, T6SS-5, and T6SS-6 are not required for virulence in this animal model of infection. |
| References | [1] Burtnick MN et al (2011) The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| AQ15_5125 | 2013966..2014937 | + | 972 | 772956756 | zinc-binding dehydrogenase family protein | ||
| AQ15_5126 | 2014992..2015918 | + | 927 | 772956769 | catalytic LigB subunit of aromatic ring-opening dioxygenase family protein | ||
| AQ15_5127 | 2016162..2017055 | - | 894 | 772958327 | bacterial regulatory helix-turn-helix, lysR family protein | ||
| T6CP013079 | TssM | AQ15_5128 | 2018346..2022422 | - | 4077 | 772958687 | intracellular multiplication and macrophage-killing family protein |
| T6CP013080 | TssL | AQ15_5129 | 2022451..2023716 | - | 1266 | 772957998 | type VI secretion system peptidoglycan-associated domain protein |
| T6CP013081 | TssK | AQ15_5130 | 2023805..2025151 | - | 1347 | 772957722 | hypothetical protein |
| T6CP013082 | TssJ | AQ15_5131 | 2025173..2025676 | - | 504 | 772958784 | type VI secretion lipofamily protein |
| T6CP013083 | TssD | AQ15_5132 | 2025783..2026268 | - | 486 | 772956684 | type VI secretion system effector, Hcp1 family protein |
| T6CP013084 | TssC | AQ15_5133 | 2026385..2027884 | - | 1500 | 772958476 | hypothetical protein |
| T6CP013085 | TssB | AQ15_5134 | 2027919..2028500 | - | 582 | 772956791 | hypothetical protein |
| T6CP013086 | TssH | AQ15_5135 (clpV) | 2028536..2031475 | - | 2940 | 772957896 | type VI secretion ATPase, ClpV1 family |
| AQ15_5136 | 2032107..2032727 | + | 621 | 772957955 | hypothetical protein | ||
| AQ15_5137 | 2032724..2033689 | + | 966 | 772956557 | impE family protein | ||
| T6CP013087 | TssE | AQ15_5138 | 2033676..2034257 | + | 582 | 772956682 | 25-like lysozyme family protein |
| T6CP013088 | TssF | AQ15_5139 | 2034300..2036177 | + | 1878 | 772957813 | hypothetical protein |
| T6CP013089 | TssG | AQ15_5140 | 2036177..2037262 | + | 1086 | 772958876 | hypothetical protein |
| T6CP013090 | TssA | AQ15_5141 | 2037259..2038404 | + | 1146 | 772956998 | hypothetical protein |
| T6CP013091 | TssI | AQ15_5142 | 2038476..2040803 | + | 2328 | 772957750 | Rhs element Vgr family protein |
| AQ15_5143 | 2040835..2043312 | + | 2478 | 772958394 | pentapeptide repeats family protein | ||
| AQ15_5144 | 2043309..2044391 | + | 1083 | 772956963 | pentapeptide repeats family protein | ||
| AQ15_5145 | 2044573..2045232 | + | 660 | 772957525 | hypothetical protein | ||
| AQ15_5146 | 2045273..2045653 | + | 381 | 772957754 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|