Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01112  |
| T6SS type | Type i1 |
| Strain | Vibrio cholerae strain A1552 |
| Replicon (RefSeq) | chromosome (NZ_CP024868) |
| Location | 116945..140733 |
| Function | - |
| Comment | Hcp protein secretion is dependent on T6SS. |
| References | [1] Cheng AT et al (2015) Vibrio cholerae Response Regulator VxrB Controls Colonization and Regulates the Type VI Secretion System. PLoS Pathog. 11(5):e1004933. [PudMed:26000450] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| VCA1552_RS14705 | 112790..114469 | - | 1680 | WP_001275247.1 | RluA family pseudouridine synthase | ||
| VCA1552_RS14710 | 115241..115525 | + | 285 | WP_000526403.1 | type VI secretion system PAAR protein | ||
| VCA1552_RS14715 | 115593..116513 | + | 921 | WP_001901866.1 | sel1 repeat family protein | ||
| T6CP014257 | TssB | VCA1552_RS14720 (tssB) | 116945..117451 | + | 507 | WP_000031391.1 | type VI secretion system contractile sheath small subunit |
| T6CP014258 | TssC | VCA1552_RS14725 (tssC) | 117495..118970 | + | 1476 | WP_000108140.1 | type VI secretion system contractile sheath large subunit |
| T6CP014259 | TssE | VCA1552_RS14730 (tssE) | 118973..119410 | + | 438 | WP_000221000.1 | type VI secretion system baseplate subunit TssE |
| T6CP014260 | TssF | VCA1552_RS14735 (tssF) | 119416..121185 | + | 1770 | WP_000189792.1 | type VI secretion system baseplate subunit TssF |
| T6CP014261 | TssG | VCA1552_RS14740 (tssG) | 121149..122165 | + | 1017 | WP_000510181.1 | type VI secretion system baseplate subunit TssG |
| VCA1552_RS14745 (tagH) | 122168..123655 | + | 1488 | WP_001089704.1 | type VI secretion system-associated FHA domain protein TagH | ||
| T6CP014262 | TssJ | VCA1552_RS14750 (tssJ) | 123658..124134 | + | 477 | WP_001045311.1 | type VI secretion system lipoprotein TssJ |
| T6CP014263 | TssK | VCA1552_RS14755 (tssK) | 124141..125475 | + | 1335 | WP_000458007.1 | type VI secretion system baseplate subunit TssK |
| T6CP014264 | TssL | VCA1552_RS14760 | 125478..126251 | + | 774 | WP_000083409.1 | type IVB secretion system protein IcmH/DotU |
| T6CP014265 | TssH | VCA1552_RS14765 (tssH) | 126277..128886 | + | 2610 | WP_000619136.1 | type VI secretion system ATPase TssH |
| VCA1552_RS14770 (vasH) | 128889..130481 | + | 1593 | WP_000084793.1 | sigma-54 dependent T6SS transcriptional regulator VasH | ||
| VCA1552_RS14775 (tagO) | 130478..131134 | + | 657 | WP_001223388.1 | type VI secretion system-associated protein TagO | ||
| T6CP014266 | TssA | VCA1552_RS14780 (vasJ) | 131144..132553 | + | 1410 | WP_000426093.1 | TssA family type VI secretion system protein VasJ |
| T6CP014267 | TssM | VCA1552_RS14785 (tssM) | 132614..136114 | + | 3501 | WP_000225015.1 | type VI secretion system membrane subunit TssM |
| T6CP014268 | TssA | VCA1552_RS14790 | 136165..137427 | + | 1263 | WP_000073077.1 | ImpA family type VI secretion system protein |
| T6CP014269 | TssI | VCA1552_RS14800 (tssI) | 137680..140733 | + | 3054 | WP_000113295.1 | type VI secretion system tip protein VgrG |
| VCA1552_RS14805 | 140730..141098 | + | 369 | WP_001061295.1 | hypothetical protein | ||
| VCA1552_RS14810 | 141246..141506 | - | 261 | WP_000799238.1 | DUF3012 domain-containing protein | ||
| VCA1552_RS14815 (rbsD) | 141790..142209 | + | 420 | WP_001911632.1 | D-ribose pyranase | ||
| VCA1552_RS14820 (rbsA) | 142236..143738 | + | 1503 | WP_000189455.1 | ribose ABC transporter ATP-binding protein RbsA | ||
| VCA1552_RS14825 (rbsC) | 143768..144736 | + | 969 | WP_001997313.1 | ribose ABC transporter permease | ||
| VCA1552_RS14830 (rbsB) | 144797..145675 | + | 879 | WP_000737186.1 | ribose ABC transporter substrate-binding protein RbsB |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed. Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01850 |
VCA1552_RS05805 (hcp) | - | - | Vibrio cholerae strain A1552 | chromosome (NZ_CP024867) | 1238150..1238668 (+) | 447065691 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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