Detailed information of regulator

Summary

Regulator ID	REG0294
Regulator type	protein
Regulatory pathway (from literatures)	Transcription regulator
KEGG pathway (determined by BlastKOALA)	-
Related T6SS	T6SS01112 (Type i1)
Strain	Vibrio cholerae strain A1552
Replicon	chromosome
Sequence	Protein sequence (99 a.a.); Nucleotide sequence (297 bp)
Description	Direct VCA0117‐mediated regulation of Hcp is dependent on RpoN (σ54) and IHF, consistent with the findings above, analysis of wild‐type V. cholerae A1552 and its isogenic IHF‐null and RpoN (σ54) derivatives showed that lack of either σ54 or IHF lead to undetectable levels of Hcp.
Reference	[1] Seibt H, Aung KM, Ishikawa T, et al. Elevated levels of VCA0117 (VasH) in response to external signals activate the type VI secretion system of Vibrio cholerae O1 El Tor A1552. Environ Microbiol. 2020 Oct;22(10):4409-4423. doi: 10.1111/1462-2920.15141. Epub 2020 Jul 10. PMID: 32592280

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External database links

Locus tag (Gene)	VCA1552_RS04890 (ihfA)
Coordinates (Strand)	1028170..1028466 (+)
NCBI ID	447152004
RefSeq	NZ_CP024867
Uniprot ID	IHFA_VIBCH, A0A0X1KW26_VIBCO, IHFA_VIBC3, D7H867_VIBCL, A0A0K9UX92_VIBCL, A0A0H3Q196_VIBCL, IHFA_VIBCM, A0A085R1G8_VIBCL
KEGG ID	vcr:VC395_1341, vco:VC0395_A0846, vcm:VCM66_1177, vcq:EN18_09425, vcx:VAA049_2519, vch:VC1222
KEGG pathway (determined by BlastKOALA)	-
PDB ID	-

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  Target

Target	Regulation (↓/↑)	Target sequence
Hcp secretion	↓	-

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Pfam domain hit(s) of regulator

Domain	Pfam ID	E-value	Aligned region
Bac_DNA_binding	PF00216.23	1.9e-31	3..91

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Transmembrane helices

• Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-98	MALTKAELAEALFEQLGMSKRDAKDTVEVFFEEIRKALESGEQVKLSGFGNFDLRDKNERPGRNPKTGEDIPITARRVVTFRPGQKLKARVENIKVEK

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Signal peptides

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9917	-	-

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  Protein sequence of regulator: 99 a.a.    .Download


  Nucleotide sequence of regulator: 297 bp    .Download