Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00301  |
| T6SS type | Type i3 |
| Strain | Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853 |
| Replicon (RefSeq) | chromosome (NC_011205) |
| Location | 305501..331344 |
| Function | anti-eukaryotic; virulence |
| Comment | Involved in colonization of the avian and murine hosts. |
| References | [1] Pezoa D et al (2014) Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts. Vet Res. 45(1):2. [PudMed:24405577] [2] Blondel CJ et al (2009) Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 0.6625. [PudMed:19653904] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TagJ | TssA | TssB | TssC | TssD | TssE | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| SED_RS01760 (mltD) | 300759..302126 | - | 1368 | WP_000644706.1 | murein transglycosylase D | ||
| SED_RS01765 (gloB) | 302198..302953 | - | 756 | WP_001052774.1 | hydroxyacylglutathione hydrolase | ||
| SED_RS01770 | 302988..303710 | + | 723 | WP_000801230.1 | class I SAM-dependent methyltransferase | ||
| SED_RS01775 (rnhA) | 303707..304174 | - | 468 | WP_000917872.1 | ribonuclease HI | ||
| SED_RS01780 (dnaQ) | 304238..304969 | + | 732 | WP_001670675.1 | DNA polymerase III subunit epsilon | ||
| T6CP003059 | TssA | SED_RS01790 | 305501..306556 | - | 1056 | WP_000367626.1 | ImpA family type VI secretion system protein |
| SED_RS01795 (tssG) | 306567..307562 | - | 996 | WP_000145239.1 | type VI secretion system baseplate subunit TssG | ||
| SED_RS01800 (tssF) | 307474..309396 | - | 1923 | WP_001675673.1 | type VI secretion system baseplate subunit TssF | ||
| T6CP003061 | TssE | SED_RS01805 (tssE) | 309412..309906 | - | 495 | WP_000108007.1 | type VI secretion system baseplate subunit TssE |
| T6CP012767 | TagJ | SED_RS01810 | 309903..310727 | - | 825 | WP_000750548.1 | hypothetical protein |
| SED_RS01815 (tagK) | 310714..311616 | - | 903 | WP_000806684.1 | type VI secretion system-associated protein TagK | ||
| T6CP003062 | TssH | SED_RS01825 (tssH) | 311984..314623 | + | 2640 | WP_000449784.1 | type VI secretion system ATPase TssH |
| T6CP003063 | TssB | SED_RS01830 (tssB) | 314723..315265 | + | 543 | WP_000996817.1 | type VI secretion system contractile sheath small subunit |
| T6CP003064 | TssC | SED_RS01835 (tssC) | 315289..316797 | + | 1509 | WP_000013881.1 | type VI secretion system contractile sheath large subunit |
| SED_RS26190 | 316864..317250 | + | 387 | WP_000323514.1 | BPSL0067 family protein | ||
| SED_RS01845 | 317377..317709 | + | 333 | WP_012532527.1 | hypothetical protein | ||
| T6CP003065 | TssD | SED_RS01850 | 317961..318446 | + | 486 | WP_000312792.1 | type VI secretion system tube protein Hcp |
| SED_RS01855 (tssJ) | 318513..319049 | + | 537 | WP_001007103.1 | type VI secretion system lipoprotein TssJ | ||
| T6CP003067 | TssK | SED_RS01860 (tssK) | 319053..320396 | + | 1344 | WP_000118732.1 | type VI secretion system baseplate subunit TssK |
| T6CP003068 | TssL | SED_RS01865 (tssL) | 320393..321697 | + | 1305 | WP_000132486.1 | type VI secretion system protein TssL, long form |
| SED_RS01870 | 321702..322475 | + | 774 | WP_000976555.1 | hypothetical protein | ||
| SED_RS01875 | 322678..323109 | + | 432 | WP_077906638.1 | Shiga toxin A subunit | ||
| T6CP003069 | TssM | SED_RS01880 (tssM) | 323143..327012 | + | 3870 | WP_001168967.1 | type VI secretion system membrane subunit TssM |
| SED_RS01885 | 327012..327800 | + | 789 | WP_001254128.1 | DUF2094 domain-containing protein | ||
| SED_RS01890 | 327797..328213 | + | 417 | WP_000759642.1 | DUF2195 family protein | ||
| SED_RS01895 | 328237..328758 | + | 522 | WP_000968384.1 | DUF2778 domain-containing protein | ||
| T6CP003070 | TssI | SED_RS01900 | 329155..331344 | + | 2190 | WP_000011530.1 | type VI secretion system tip protein VgrG |
| SED_RS01905 | 331368..331814 | + | 447 | WP_000375834.1 | DcrB-related protein | ||
| SED_RS01910 | 331833..335584 | + | 3752 | pseudogene | PAAR domain-containing protein | ||
| SED_RS24315 | 335568..335909 | + | 342 | WP_001751274.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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