SecReT6, T6SS database

Detailed information of component protein

Summary

Component ID	T6CP003067
Component protein type	TssK
T6SS ID (Type)	T6SS00301 (Type i3)
Strain	Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853
Replicon	chromosome
Sequence	Protein sequence (448 a.a.); Nucleotide sequence (1344 bp)
Reference	[1] Blondel CJ, Jiménez JC, Contreras I, et al. Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 2009 Aug 4;10:354. doi: 10.1186/1471-2164-10-354. PMID: 19653904 [2] Pezoa D, Blondel CJ, Silva CA, et al. Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts. Vet Res. 2014 Jan 9;45:2. doi: 10.1186/1297-9716-45-2. PMID: 24405577

Experimental investigation has been performed on this T6SS

External database links

Locus tag (Gene)	SED_RS01860
Coordinate (Strand)	319053..320396 (+)
NCBI ID	446040877
RefSeq	NC_011205
Uniprot ID	A0A0R9NUA6_SALNE, V7IHI5_SALET, M7S6S3_SALDU, A0A2T8L441_SALET, A0A0H3N9I2_SALTS, F5CQ78_SALER, A0A0H2WSR2_SALPA, A0A2T9Q8X6_SALET, A0A2T8QQ36_SALET, A0A0H3BS82_SALNS, A0A0F6AX83_SALT1, A0A265B9Z2_SALET, Q83SZ6_SALTI, H9L4F9_SALTM, E8XIU6_SALT4, Q93IS1_SALTY
KEGG ID	see:SNSL254_A0307, sey:SL1344_0276, stt:t2582, spt:SPA2483, seni:CY43_01405, seo:STM14_0329, stm:STM0281, seb:STM474_0293
PDB ID	-

Pfam domain hit(s)

Domain	Pfam ID	E-value	Aligned region
T6SS_VasE	PF05936.14	2e-135	20..444

Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-447	MSWNDRVVWSEGQFLLPQMFQQQERYLEHVMHYRSLPLTPFFWGFSHYNIDGEALNIGKLILKEASGIFPDGTPFNAPDHTPLPPPLTILPEHLNQQICLAVPVRAPNSEETTFDNNPESLARFSVHEHDIRDANSLGRGAQLLQLSHLRLRLLPEKAVTGAWIGLPLTRITGLNPDGRIDIDHDLIPPIINYQASSLMCTWLSWINDLIRMRADSLAERLTGSDNHGHEAAEVSDYLLLQILNRFEPLLTHLAKTPLAPEVLYRYLSELAGELSTYVRPQTRRPAEYKEYKHLTPYAGLKSLVDEVQFLLNAVLIRGAQRIELKEGTYGILNAVVAPSDLADFSTLVLAIKASMPTDVLLQHFAAQTKIGPSDRLPELIRSHLPGLALQVLPVPPRQIPFQAGYIYYDIRREGALWEHIARYGGMAMHTAGEFPGLETELWGVRDK

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9970	-	-

Protein sequence: 448 a.a.

						>T6CP003067 NC_011205:319053-320396 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853] [TssK]
MSWNDRVVWSEGQFLLPQMFQQQERYLEHVMHYRSLPLTPFFWGFSHYNIDGEALNIGKLILKEASGIFPDGTPFNAPDH
TPLPPPLTILPEHLNQQICLAVPVRAPNSEETTFDNNPESLARFSVHEHDIRDANSLGRGAQLLQLSHLRLRLLPEKAVT
GAWIGLPLTRITGLNPDGRIDIDHDLIPPIINYQASSLMCTWLSWINDLIRMRADSLAERLTGSDNHGHEAAEVSDYLLL
QILNRFEPLLTHLAKTPLAPEVLYRYLSELAGELSTYVRPQTRRPAEYKEYKHLTPYAGLKSLVDEVQFLLNAVLIRGAQ
RIELKEGTYGILNAVVAPSDLADFSTLVLAIKASMPTDVLLQHFAAQTKIGPSDRLPELIRSHLPGLALQVLPVPPRQIP
FQAGYIYYDIRREGALWEHIARYGGMAMHTAGEFPGLETELWGVRDK*					

Nucleotide sequence: 1344 bp

						>T6CP003067 NC_011205:319053-320396 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853] [TssK]
ATGAGCTGGAATGACCGCGTAGTCTGGAGTGAAGGACAATTTTTACTGCCGCAGATGTTTCAGCAGCAAGAGCGTTATCT
GGAACACGTCATGCATTACCGCAGCCTGCCGCTGACCCCCTTTTTCTGGGGATTCAGCCACTACAATATTGATGGCGAAG
CGCTGAACATCGGTAAACTGATACTGAAAGAGGCATCAGGGATTTTTCCTGACGGTACGCCGTTTAACGCACCGGACCAT
ACCCCGCTGCCGCCGCCGCTGACCATCCTGCCGGAGCACCTGAACCAGCAGATTTGTCTGGCGGTACCGGTACGCGCGCC
GAACAGCGAAGAAACTACGTTTGACAATAACCCGGAATCACTGGCGCGTTTCTCGGTACACGAACACGACATCCGCGACG
CCAACTCGCTGGGACGTGGCGCGCAGTTATTACAGCTCAGTCACCTGCGCCTGCGGCTGCTGCCGGAAAAGGCGGTGACG
GGCGCCTGGATTGGCCTGCCGCTGACCCGCATCACCGGGCTGAACCCTGACGGGCGGATAGATATCGACCACGACCTGAT
CCCGCCCATCATTAATTATCAGGCCAGTTCACTGATGTGTACCTGGCTGTCGTGGATCAACGATCTCATCCGGATGCGGG
CCGATTCGCTGGCGGAACGGCTGACCGGCAGCGACAACCACGGCCATGAAGCAGCAGAGGTCTCCGATTACCTGCTGCTG
CAAATTCTCAATCGCTTTGAGCCGCTGCTGACTCACCTGGCGAAAACCCCGCTGGCCCCGGAAGTGTTGTATCGCTACCT
GTCCGAACTGGCCGGGGAACTCTCCACCTATGTGCGTCCACAAACGCGACGGCCCGCTGAATATAAAGAGTACAAACACC
TGACGCCCTATGCCGGGTTGAAATCACTGGTCGATGAGGTGCAGTTCCTGCTGAATGCAGTACTGATCCGGGGCGCGCAG
CGCATCGAGCTGAAAGAGGGGACTTACGGCATCCTGAATGCGGTGGTGGCTCCTTCCGATCTTGCCGATTTCAGCACGCT
GGTACTGGCGATAAAGGCTTCAATGCCGACCGATGTGCTACTGCAACATTTTGCCGCCCAGACCAAAATCGGGCCATCCG
ATCGCCTGCCGGAACTGATCCGCTCGCATCTGCCGGGGCTGGCTTTGCAGGTTCTGCCTGTACCACCGCGCCAAATCCCG
TTTCAGGCCGGATACATCTATTACGACATCCGCCGCGAGGGAGCATTGTGGGAACACATTGCCCGTTACGGCGGGATGGC
CATGCATACCGCCGGGGAATTTCCGGGGCTGGAGACAGAACTGTGGGGAGTGCGCGATAAATGA					