Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS01274 experimental
T6SS type Type i2
Strain Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Replicon (RefSeq) chromosome (NZ_CP064352)
Location 1759057..1784245
Function -
Comment Kp43816 possess T6SS-dependent anti-bacterial activity
References
[1] Storey D, McNally A, strand M, Sa-Pessoa Graca Santos J, Rodriguez-Escudero I, Elmore B, Palacios L, Marshall H, Hobley L, Molina M, Cid VJ, Salminen TA, Bengoechea JA. et al (2020) Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent.. PLoS Pathog. 16(3):e1007969. [PudMed:32191774]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentTssATssBTssDTssFTssGTssHTssITssJTssKTssLVasK
Number11111111111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
IT767_RS08485 1754935..1755141 + 207 WP_004176413.1 DUF1471 domain-containing protein
IT767_RS08490 1755192..1756070 - 879 WP_004151595.1 AraC family transcriptional regulator
IT767_RS08495 1756229..1756984 + 756 WP_004151596.1 SDR family oxidoreductase
IT767_RS08500 1756989..1757582 - 594 WP_015958263.1 TetR/AcrR family transcriptional regulator
IT767_RS08505 (bdcA) 1757656..1758369 + 714 WP_004176415.1 SDR family oxidoreductase
IT767_RS08510 1758436..1758930 - 495 WP_038431758.1 hypothetical protein
T6CP015834 TssJ IT767_RS08515 (tssJ) 1759057..1759599 - 543 WP_004176417.1 type VI secretion system lipoprotein TssJ
T6CP015835 TssG IT767_RS08520 (tssG) 1759577..1760662 - 1086 WP_004212345.1 type VI secretion system baseplate subunit TssG
T6CP015836 TssF IT767_RS08525 (tssF) 1760626..1762380 - 1755 WP_004892596.1 type VI secretion system baseplate subunit TssF
T6CP015837 TssA IT767_RS08530 (tssA) 1762460..1764052 - 1593 WP_004183804.1 type VI secretion system protein TssA
T6CP015838 VasK IT767_RS08535 1764049..1767498 - 3450 WP_038431759.1 type VI secretion protein VasK
T6CP015839 TssI IT767_RS08540 1767488..1768669 - 1182 WP_021440008.1 hypothetical protein
IT767_RS08545 1768618..1768875 - 258 WP_023302025.1 PAAR domain-containing protein
IT767_RS08550 1768918..1771317 - 2400 WP_021440007.1 DUF2235 domain-containing protein
IT767_RS08555 1771305..1771834 - 530 pseudogene DUF3304 domain-containing protein
IT767_RS08560 1771859..1772635 - 777 WP_004140184.1 DUF4123 domain-containing protein
IT767_RS08565 (vgrG) 1772639..1775008 - 2370 pseudogene type VI secretion system tip protein VgrG
T6CP015840 TssH IT767_RS08570 (tssH) 1775010..1777664 - 2655 WP_038431760.1 type VI secretion system ATPase TssH
T6CP015841 TssD IT767_RS08575 (hcp) 1777929..1778420 - 492 WP_002902160.1 type VI secretion system effector Hcp
IT767_RS08580 1778425..1780131 - 1707 WP_038431761.1 OmpA family protein
T6CP015842 TssL IT767_RS08585 1780128..1780817 - 690 WP_004176431.1 type VI secretion system protein TssL, short form
T6CP015843 TssK IT767_RS08590 (tssK) 1780814..1782157 - 1344 WP_004224345.1 type VI secretion system baseplate subunit TssK
IT767_RS08595 (tssC) 1782167..1783711 - 1545 pseudogene type VI secretion system contractile sheath large subunit
T6CP015845 TssB IT767_RS08600 (tssB) 1783754..1784245 - 492 WP_004176434.1 type VI secretion system contractile sheath small subunit
IT767_RS08605 1784886..1785452 + 567 WP_038431762.1 DJ-1/PfpI family protein
IT767_RS08610 1785651..1787183 - 1533 WP_004224331.1 HD domain-containing protein
IT767_RS08615 1787400..1788161 - 762 WP_038431763.1 SDR family oxidoreductase
IT767_RS08620 1788270..1789184 + 915 WP_038431764.1 LysR family transcriptional regulator
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector