SecReT6, T6SS database

Detailed information of effector

Summary

Effector ID	EFF00110
Effector type	-
Cognate immunity protein	-
Related T6SS (Type)	T6SS00081 (Type ii)
Strain	Francisella tularensis subsp. tularensis SCHU S4
Replicon	chromosome
Sequence	Protein sequence (165 a.a.); Nucleotide sequence (495 bp)
Description	-
Reference	[1] Bröms JE, Lavander M, Meyer L, et al. IglG and IglI of the Francisella pathogenicity island are important virulence determinants of Francisella tularensis LVS. Infect Immun. 2011 Sep;79(9):3683-96. doi: 10.1128/IAI.01344-10. Epub 2011 Jun 20. PMID: 21690239 [2] Dai S, Mohapatra NP, Schlesinger LS, et al. The acid phosphatase AcpA is secreted in vitro and in macrophages by Francisella spp. Infect Immun. 2012 Mar;80(3):1088-97. doi: 10.1128/IAI.06245-11. Epub 2011 Dec 19. PMID: 22184418

Experimental investigation has been performed.

Bioinformatics investigation has been performed

External database links

Locus tag (Gene)	FTT_1347 (VgrG)
Coordinates (Strand)	1386053..1386547 (+)
NCBI ID	56708403
RefSeq	NC_006570
Uniprot ID	Q5NED5_FRATT
KEGG ID	ftu:FTT_1347, ftu:FTT_1702
PDB ID	-

Pfam domain hit(s)

Domain	Pfam ID	E-value	Aligned region

Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-164	MSKADHIFNLEEQGLLIDIKDDSKGCTTKLESSGKITHNATESIESSADKQIIENVKDSKISITEKEILLATKKSSIMLSEDKIVIKIGNSLIILDDSNISLESATINIKSSANINIQASQNIDIKSLNNSIKADVNLNAEGLDVNIKGSVTASIKGSTATMVG

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9898	-	-

Protein sequence: 165 a.a. .

                                    >EFF00110 NC_006570:1386053-1386547  (Unknown) [Francisella tularensis subsp. tularensis SCHU S4]
MSKADHIFNLEEQGLLIDIKDDSKGCTTKLESSGKITHNATESIESSADKQIIENVKDSKISITEKEILLATKKSSIMLS
EDKIVIKIGNSLIILDDSNISLESATINIKSSANINIQASQNIDIKSLNNSIKADVNLNAEGLDVNIKGSVTASIKGSTA
TMVG*

                                

Nucleotide sequence: 495 bp .

                                    >EFF00110 NC_006570:1386053-1386547  (Unknown) [Francisella tularensis subsp. tularensis SCHU S4]
ATGTCAAAAGCAGACCATATTTTCAACTTAGAAGAGCAAGGCTTGCTCATAGATATCAAAGATGATTCAAAAGGCTGCAC
TACGAAACTAGAGTCCTCTGGAAAAATCACTCATAATGCAACTGAATCGATAGAGTCAAGCGCTGATAAACAAATAATTG
AAAATGTCAAAGACTCAAAAATATCAATAACTGAAAAAGAAATTTTGTTAGCTACTAAGAAATCAAGCATTATGCTTAGT
GAAGATAAAATTGTCATAAAAATAGGTAATTCTTTAATTATACTTGATGATTCAAATATTTCGCTAGAGTCTGCAACTAT
TAATATAAAAAGCTCTGCTAATATAAATATTCAAGCATCACAGAACATAGATATAAAAAGTCTAAATAATAGTATCAAAG
CAGATGTAAACCTTAATGCTGAAGGGTTAGATGTAAATATTAAAGGAAGTGTAACAGCAAGCATAAAAGGTTCTACAGCA
ACAATGGTTGGATAA

                                