Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00081 experimental
T6SS type Type ii
Strain Francisella tularensis subsp. tularensis SCHU S4
Replicon (RefSeq) chromosome (NC_006570)
Location 1379925..1405040
Function anti-eukaryotic; effector translocation; virulence
Comment -
References
[1] Broms JE et al (2012) Unique Substrates Secreted by the Type VI Secretion System of Francisella tularensis during Intramacrophage Infection. PLoS One. 7(11):e50473. [PudMed:23185631]
[2] Nano FE et al (2007) The Francisella pathogenicity island. Ann N Y Acad Sci. 1105:122-37. [PudMed:17395722]
[3] Long ME et al (2013) Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice, and reveals a unique phenotype for pdpC. Infect Immun. 81(3):850-61. [PudMed:23275090]
[4] Long ME et al (2013) Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice, and reveals a unique phenotype for pdpC. Infect Immun. 81(3):850-61. [PudMed:23275090]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentIglCIglDIglEIglFIglGIglHIglIIglJPdpAPdpBPdpCPdpDPdpETssBTssCTssITssL
Number11111111111111111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
T6CP005164 PdpA FTT_RS07050 1379925..1382387 + 2463 WP_003022122.1 hypothetical protein
T6CP005165 PdpB FTT_RS07055 1382392..1385673 + 3282 WP_003022126.1 hypothetical protein
T6CP005166 IglE FTT_RS07060 1385663..1386040 + 378 WP_003022128.1 hypothetical protein
T6CP005167 TssI FTT_RS07065 1386053..1386547 + 495 WP_003016192.1 hypothetical protein
T6CP005168 IglF FTT_RS07070 1386552..1388282 + 1731 WP_003022130.1 hypothetical protein
T6CP005169 IglG FTT_RS07075 1388283..1388804 + 522 WP_003018233.1 DUF4280 domain-containing protein
T6CP005170 IglH FTT_RS07080 1388817..1390247 + 1431 WP_003022137.1 hypothetical protein
T6CP005171 TssL FTT_RS07085 1390260..1390883 + 624 WP_003016181.1 DotU family type IV/VI secretion system protein
T6CP005172 IglI FTT_RS07090 1390905..1392056 + 1152 WP_003016179.1 hypothetical protein
T6CP005173 IglJ FTT_RS07095 1392022..1392795 + 774 WP_003022141.1 hypothetical protein
T6CP005174 PdpC FTT_RS07100 (pdpC) 1392835..1396821 + 3987 WP_003022143.1 pathogenicity determinant protein PdpC
T6CP005175 PdpE FTT_RS07105 1396839..1397414 + 576 WP_003022145.1 hypothetical protein
T6CP005176 IglD FTT_RS07110 1397421..1398617 - 1197 WP_003023944.1 hypothetical protein
T6CP005177 IglC FTT_RS07115 1398638..1399267 - 630 WP_014367985.1 Intracellular growth locus subunit C
T6CP005178 TssC FTT_RS07120 (tssC) 1399284..1400804 - 1521 WP_003022151.1 type VI secretion system contractile sheath large subunit
T6CP005179 TssB FTT_RS07125 (tssB) 1400818..1401372 - 555 WP_003022153.1 type VI secretion system contractile sheath small subunit
T6CP005180 PdpD FTT_RS07130 1401453..1405040 - 3588 WP_003022155.1 hypothetical protein
FTT_RS07135 1405140..1406255 - 1116 pseudogene anhydro-N-acetylmuramic acid kinase
FTT_RS07140 1406490..1407299 + 810 WP_075360614.1 MFS transporter
FTT_RS07145 1407396..1408180 - 785 WP_004578540.1 IS630-like element ISFtu1 family transposase
FTT_RS07150 1408328..1408585 + 258 WP_003023981.1 hypothetical protein
FTT_RS07155 1408587..1410038 + 1452 pseudogene alpha,alpha-trehalase
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0147 experimental FTT1557c/FNU0663.2 (pmrA) protein TCS-RR Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 1618742..1619428 (-) 489108239 T6SS transcription (↓)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
EFF00110 experimental FTT_1347 (VgrG) - - Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 1386053..1386547 (+) 56708403
EFF00111 experimental FTL_0118 (IglI) - - Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 1390905..1392056 (+) 56708408

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector
ACP00020 experimental FTT_0682c (fipB/dsbA) chaperone Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 699171..700016 (-) 56707802 FTT_1358c (IglB1); FTT_1357c (IglC1) -