Detailed information of regulator
Summary
| Regulator ID | REG0379  |
| Regulator type | protein |
| Regulatory pathway (from literatures) | Global regulator |
| KEGG pathway (determined by BlastKOALA) | - |
| Related T6SS | T6SS17507 (Type i4a) |
| Strain | Cupriavidus pinatubonensis JMP134 |
| Replicon | chromosome |
| Sequence | Protein sequence (144 a.a.); Nucleotide sequence (432 bp) |
| Description | The expression of T6SS1 in C. necator is directly repressed by Fur. |
| Reference |
External database links
| Locus tag (Gene) | REUT_RS14415 (fur) |
| Coordinates (Strand) | 3110053..3110484 (+) |
| NCBI ID | WP_011298983.1 |
| RefSeq | NC_007347 |
| Uniprot ID | Q46XD5_CUPPJ |
| KEGG ID | reu:Reut_A2837 |
| KEGG pathway (determined by BlastKOALA) | - |
| PDB ID | - |
Target
| Target | Regulation (↓/↑) | Target sequence |
|---|---|---|
| reut_A1733 promotor | ↑ | AGAAATA |
Pfam domain hit(s) of regulator
| Domain | Pfam ID | E-value | Aligned region |
|---|---|---|---|
| FUR | PF01475.21 | 2.8e-46 | 10..129 |
Transmembrane helices
- Transmembrane helices are predicted using TMHMM 2.0 software.
| Prediction | Region | Sequence |
|---|---|---|
| Outside | 1-143 | MPSPAELKNIGLKATVPRLKILEIFQTSEQRHLSAEDVYRILLNEHMDIGLATVYRVLTQFEQAGLLSRNNFESGKAIFELNEGKHHDHLVCLDCGRVEEFFDGEIEQRQQSIARERGFALQEHALSLYGNCTKTDCPHRPKR |
Signal peptides
- Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
- Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
- Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
| Prediction | Probability | Cleavage site | Signal peptide sequence |
|---|---|---|---|
| Other | 0.9972 | - | - |
Protein sequence of regulator: 144 a.a. .
>REG0379 NC_007347:3110053-3110484 [Cupriavidus pinatubonensis JMP134]
MPSPAELKNIGLKATVPRLKILEIFQTSEQRHLSAEDVYRILLNEHMDIGLATVYRVLTQFEQAGLLSRNNFESGKAIFE
LNEGKHHDHLVCLDCGRVEEFFDGEIEQRQQSIARERGFALQEHALSLYGNCTKTDCPHRPKR*
MPSPAELKNIGLKATVPRLKILEIFQTSEQRHLSAEDVYRILLNEHMDIGLATVYRVLTQFEQAGLLSRNNFESGKAIFE
LNEGKHHDHLVCLDCGRVEEFFDGEIEQRQQSIARERGFALQEHALSLYGNCTKTDCPHRPKR*
Nucleotide sequence of regulator: 432 bp .
>REG0379 NC_007347:3110053-3110484 [Cupriavidus pinatubonensis JMP134]
ATGCCGAGTCCGGCGGAGCTCAAGAATATCGGCCTAAAGGCGACCGTGCCGCGGCTGAAAATTCTTGAGATTTTTCAGAC
CAGTGAACAGCGCCACCTGAGCGCTGAAGACGTCTACCGAATCCTGCTCAACGAGCATATGGATATCGGCCTGGCGACCG
TTTACCGTGTGCTCACCCAGTTCGAGCAGGCGGGCCTTCTGTCGCGCAACAATTTCGAATCCGGCAAGGCCATTTTCGAG
CTCAACGAAGGCAAGCACCACGACCACTTGGTATGCCTCGATTGCGGCCGCGTGGAGGAGTTCTTCGACGGCGAGATCGA
GCAACGCCAGCAAAGCATCGCGCGCGAACGCGGCTTTGCGCTGCAGGAACATGCGTTGTCGCTGTACGGCAACTGCACCA
AAACTGATTGTCCCCACAGACCAAAACGATAA
ATGCCGAGTCCGGCGGAGCTCAAGAATATCGGCCTAAAGGCGACCGTGCCGCGGCTGAAAATTCTTGAGATTTTTCAGAC
CAGTGAACAGCGCCACCTGAGCGCTGAAGACGTCTACCGAATCCTGCTCAACGAGCATATGGATATCGGCCTGGCGACCG
TTTACCGTGTGCTCACCCAGTTCGAGCAGGCGGGCCTTCTGTCGCGCAACAATTTCGAATCCGGCAAGGCCATTTTCGAG
CTCAACGAAGGCAAGCACCACGACCACTTGGTATGCCTCGATTGCGGCCGCGTGGAGGAGTTCTTCGACGGCGAGATCGA
GCAACGCCAGCAAAGCATCGCGCGCGAACGCGGCTTTGCGCTGCAGGAACATGCGTTGTCGCTGTACGGCAACTGCACCA
AAACTGATTGTCCCCACAGACCAAAACGATAA