Detailed information of regulator
Summary
| Regulator ID | REG0021  |
| Regulator type | protein |
| Regulatory pathway (from literatures) | Unknown |
| KEGG pathway (determined by BlastKOALA) | - |
| Related T6SS | T6SS01168 (Type i1) |
| Strain | Vibrio cholerae C6706 |
| Replicon | chromosome |
| Sequence | Protein sequence (336 a.a.); Nucleotide sequence (1008 bp) |
| Description | CytR is a Global regulator in Vibrio cholerae and is required for bacterial killing via the Type VI secretion system and mediated solely via QstR-upregulation. |
| Reference |
External database links
| Locus tag (Gene) | GPY04_RS11195 (CytR) |
| Coordinates (Strand) | 2449479..2450486 (-) |
| NCBI ID | 446146597 |
| RefSeq | NZ_CP046844 |
| Uniprot ID | Q9KNQ4_VIBCH, A0A0X1L485_VIBCO, A0A0H3AJ95_VIBC3, D7HFV5_VIBCL, A0A0K9UP89_VIBCL, A0A0H3Q7N4_VIBCL, C3LSA6_VIBCM, A0A085RG68_VIBCL, A0A1D8S819_VIBMI |
| KEGG ID | vcm:VCM66_2597, vch:VC2677, vco:VC0395_A2250, vmi:AL543_08230, vcq:EN18_16390 |
| KEGG pathway (determined by BlastKOALA) | - |
| PDB ID | - |
Target
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Target | Regulation (↓/↑) | Target sequence |
|---|---|---|
| Unknown | ↓ | - |
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Pfam domain hit(s) of regulator
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Domain | Pfam ID | E-value | Aligned region |
|---|---|---|---|
| Peripla_BP_3 | PF13377.8 | 1.9e-43 | 168..328 |
| LacI | PF00356.23 | 5e-20 | 3..48 |
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Transmembrane helices
- Transmembrane helices are predicted using TMHMM 2.0 software.
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Prediction | Region | Sequence |
|---|---|---|
| Outside | 1-335 | MATMKDVAQLAGVSTATVSRALMNPEKVSSSTRKRVEEAVLEAGYSPNSLARNLRRNESKTIVAIVPDICDPYFSEIIRGIEDAAMEHGYLVLLGDSGQQKRRENSFVNLVFTKQADGMLLLGTDLPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDNLTSAFEAVNYLTQLGHKRIAQISGPQHAALCQFRHQGYQQALRRAGITMNPTYCTFGDFTFEAGAKAVRQLLALPEQPTAIFCHNDTMAIGAIQEAKRLGLRVPQDLSVVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLELLRGHDVRAGSRLLETKLVVRESAAPPSKK |
Signal peptides
- Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
- Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
- Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction | Probability | Cleavage site | Signal peptide sequence |
|---|---|---|---|
| Other | 0.8850 | - | - |
Protein sequence of regulator: 336 a.a. .
>REG0021 NZ_CP046844:c2450486-2449479 [Vibrio cholerae C6706]
MATMKDVAQLAGVSTATVSRALMNPEKVSSSTRKRVEEAVLEAGYSPNSLARNLRRNESKTIVAIVPDICDPYFSEIIRG
IEDAAMEHGYLVLLGDSGQQKRRENSFVNLVFTKQADGMLLLGTDLPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDN
LTSAFEAVNYLTQLGHKRIAQISGPQHAALCQFRHQGYQQALRRAGITMNPTYCTFGDFTFEAGAKAVRQLLALPEQPTA
IFCHNDTMAIGAIQEAKRLGLRVPQDLSVVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLELLRGHDVRAGSRLLE
TKLVVRESAAPPSKK*
MATMKDVAQLAGVSTATVSRALMNPEKVSSSTRKRVEEAVLEAGYSPNSLARNLRRNESKTIVAIVPDICDPYFSEIIRG
IEDAAMEHGYLVLLGDSGQQKRRENSFVNLVFTKQADGMLLLGTDLPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDN
LTSAFEAVNYLTQLGHKRIAQISGPQHAALCQFRHQGYQQALRRAGITMNPTYCTFGDFTFEAGAKAVRQLLALPEQPTA
IFCHNDTMAIGAIQEAKRLGLRVPQDLSVVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLELLRGHDVRAGSRLLE
TKLVVRESAAPPSKK*
Nucleotide sequence of regulator: 1008 bp .
>REG0021 NZ_CP046844:c2450486-2449479 [Vibrio cholerae C6706]
ATGGCGACAATGAAGGATGTTGCCCAGCTTGCTGGAGTTTCAACCGCGACCGTGTCTCGTGCGTTGATGAATCCAGAGAA
AGTCTCGTCGTCCACTCGTAAACGAGTGGAAGAGGCCGTGCTGGAAGCGGGTTACTCACCCAATTCTTTGGCGCGCAATT
TGCGCCGTAATGAATCGAAAACCATCGTTGCTATCGTGCCAGATATCTGTGATCCCTACTTTTCTGAGATCATTCGCGGT
ATTGAAGATGCCGCGATGGAGCACGGTTATCTGGTGCTGTTGGGGGATAGTGGTCAACAGAAGCGTCGGGAGAACTCGTT
CGTTAATCTGGTGTTTACCAAACAGGCAGACGGTATGTTGCTGCTGGGGACAGATTTGCCGTTTGATGTGAGTAAACCTG
AGCAGAAAAACCTACCGCCTATGGTGATGGCGTGTGAATTTGCGCCAGAGCTGGAATTGCCAACGGTACACATTGATAAC
CTGACCTCGGCATTTGAGGCGGTAAACTATCTCACTCAGCTTGGGCACAAACGGATTGCGCAGATCTCAGGTCCACAACA
TGCTGCGCTGTGCCAATTCCGTCATCAAGGCTATCAACAGGCGTTGCGTCGTGCTGGCATCACCATGAACCCGACTTACT
GCACTTTTGGCGATTTCACTTTTGAAGCCGGGGCAAAAGCGGTGCGTCAGCTGTTGGCATTGCCTGAGCAGCCGACCGCG
ATTTTCTGTCATAACGATACGATGGCGATTGGCGCAATTCAGGAAGCGAAGCGACTTGGCTTGCGCGTACCGCAAGATCT
CTCTGTGGTCGGTTTTGACGATATTCAGTTTGCCCAGTACTGCGATCCCCCATTAACCACCATTTCGCAGCCGCGTTATG
AGATTGGCCGTCAAGCCATGCTGATGATGCTTGAGCTGCTTCGCGGACACGATGTACGTGCTGGATCGCGTCTTTTGGAG
ACCAAGCTGGTCGTGCGTGAGAGTGCTGCGCCGCCAAGCAAGAAGTAA
ATGGCGACAATGAAGGATGTTGCCCAGCTTGCTGGAGTTTCAACCGCGACCGTGTCTCGTGCGTTGATGAATCCAGAGAA
AGTCTCGTCGTCCACTCGTAAACGAGTGGAAGAGGCCGTGCTGGAAGCGGGTTACTCACCCAATTCTTTGGCGCGCAATT
TGCGCCGTAATGAATCGAAAACCATCGTTGCTATCGTGCCAGATATCTGTGATCCCTACTTTTCTGAGATCATTCGCGGT
ATTGAAGATGCCGCGATGGAGCACGGTTATCTGGTGCTGTTGGGGGATAGTGGTCAACAGAAGCGTCGGGAGAACTCGTT
CGTTAATCTGGTGTTTACCAAACAGGCAGACGGTATGTTGCTGCTGGGGACAGATTTGCCGTTTGATGTGAGTAAACCTG
AGCAGAAAAACCTACCGCCTATGGTGATGGCGTGTGAATTTGCGCCAGAGCTGGAATTGCCAACGGTACACATTGATAAC
CTGACCTCGGCATTTGAGGCGGTAAACTATCTCACTCAGCTTGGGCACAAACGGATTGCGCAGATCTCAGGTCCACAACA
TGCTGCGCTGTGCCAATTCCGTCATCAAGGCTATCAACAGGCGTTGCGTCGTGCTGGCATCACCATGAACCCGACTTACT
GCACTTTTGGCGATTTCACTTTTGAAGCCGGGGCAAAAGCGGTGCGTCAGCTGTTGGCATTGCCTGAGCAGCCGACCGCG
ATTTTCTGTCATAACGATACGATGGCGATTGGCGCAATTCAGGAAGCGAAGCGACTTGGCTTGCGCGTACCGCAAGATCT
CTCTGTGGTCGGTTTTGACGATATTCAGTTTGCCCAGTACTGCGATCCCCCATTAACCACCATTTCGCAGCCGCGTTATG
AGATTGGCCGTCAAGCCATGCTGATGATGCTTGAGCTGCTTCGCGGACACGATGTACGTGCTGGATCGCGTCTTTTGGAG
ACCAAGCTGGTCGTGCGTGAGAGTGCTGCGCCGCCAAGCAAGAAGTAA