Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00006  |
| T6SS type | Type i1 |
| Strain | Escherichia coli O157:H7 str. EDL933 |
| Replicon (RefSeq) | chromosome (NC_002655) |
| Location | 238349..271907 |
| Function | - |
| Comment | - |
| References | [1] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] |
Bioinformatics investigation has been performed.T6SS components and genome coordinates
| Component | FHA | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| Z_RS01080 (yafD) | 234452..235252 | + | 801 | WP_001230983.1 | endonuclease/exonuclease/phosphatase family protein | ||
| Z_RS01085 | 235330..236100 | + | 771 | WP_000211693.1 | class I SAM-dependent methyltransferase | ||
| Z_RS01090 (mltD) | 236148..237506 | - | 1359 | WP_000644686.1 | murein transglycosylase D | ||
| Z_RS01095 (gloB) | 237578..238333 | - | 756 | WP_001052715.1 | hydroxyacylglutathione hydrolase | ||
| Z_RS01100 (yafS) | 238367..239089 | + | 723 | WP_001301721.1 | class I SAM-dependent methyltransferase | ||
| Z_RS01105 (rnhA) | 239086..239553 | - | 468 | WP_000917883.1 | ribonuclease HI | ||
| Z_RS01110 (dnaQ) | 239618..240349 | + | 732 | WP_001301976.1 | DNA polymerase III subunit epsilon | ||
| Z_RS01120 | 240887..241687 | + | 801 | WP_001086136.1 | hypothetical protein | ||
| Z_RS01130 | 242165..242614 | - | 450 | WP_001302684.1 | DUF1311 domain-containing protein | ||
| Z_RS01135 | 242617..243213 | - | 597 | WP_000964776.1 | hypothetical protein | ||
| Z_RS28955 | 243292..243513 | - | 222 | WP_000002701.1 | hypothetical protein | ||
| T6CP008381 | TssD | Z_RS01140 | 243534..244013 | - | 480 | WP_001284958.1 | Hcp family type VI secretion system effector |
| T6CP008382 | TssA | Z_RS01145 | 243979..245388 | - | 1410 | WP_001087743.1 | type VI secretion system ImpA and VasL domain-containing protein |
| T6CP000030 | TssM | Z_RS01150 (tssM) | 245399..248833 | - | 3435 | WP_001303798.1 | type VI secretion system membrane subunit TssM |
| Z_RS01155 (tssA) | 248970..250381 | - | 1412 | pseudogene | type VI secretion system protein TssA | ||
| Z_RS01165 (tagO) | 250386..251129 | - | 744 | WP_000088854.1 | type VI secretion system-associated protein TagO | ||
| T6CP000031 | TssH | Z_RS01170 (tssH) | 251126..253897 | - | 2772 | WP_000614374.1 | type VI secretion system ATPase TssH |
| T6CP000032 | TssL | Z_RS01175 (icmH) | 253906..254667 | - | 762 | WP_000343292.1 | type IVB secretion system protein IcmH/DotU |
| T6CP000033 | TssK | Z_RS01180 (tssK) | 254672..256003 | - | 1332 | WP_000246434.1 | type VI secretion system baseplate subunit TssK |
| T6CP000034 | TssJ | Z_RS01185 (tssJ) | 256006..256530 | - | 525 | WP_001080153.1 | type VI secretion system lipoprotein TssJ |
| T6CP011391 | FHA | Z_RS01190 (tagH) | 256527..257807 | - | 1281 | WP_001113707.1 | type VI secretion system-associated FHA domain protein TagH |
| T6CP000035 | TssG | Z_RS01195 (tssG) | 257832..258914 | - | 1083 | WP_000348794.1 | type VI secretion system baseplate subunit TssG |
| T6CP000036 | TssF | Z_RS01200 (tssF) | 258878..260728 | - | 1851 | WP_000393844.1 | type VI secretion system baseplate subunit TssF |
| T6CP008384 | TssE | Z_RS01205 (tssE) | 260732..261145 | - | 414 | WP_000599596.1 | type VI secretion system baseplate subunit TssE |
| T6CP000037 | TssC | Z_RS01210 (tssC) | 261236..262627 | - | 1392 | WP_000056994.1 | type VI secretion system contractile sheath large subunit |
| Z_RS01215 | 262678..262902 | - | 225 | WP_000123970.1 | hypothetical protein | ||
| T6CP000038 | TssB | Z_RS01220 (tssB) | 262937..263437 | - | 501 | WP_000037399.1 | type VI secretion system contractile sheath small subunit |
| T6CP008385 | TssD | Z_RS01230 | 264134..264652 | + | 519 | WP_001142958.1 | Hcp family type VI secretion system effector |
| T6CP000039 | TssI | Z_RS01240 | 264862..267003 | + | 2142 | WP_000103125.1 | type VI secretion system tip protein VgrG |
| T6CP011392 | PAAR | Z_RS01245 | 267079..271293 | + | 4215 | WP_000509132.1 | RHS repeat protein |
| Z_RS01250 | 271362..271907 | + | 546 | WP_001356493.1 | sel1 repeat family protein | ||
| Z_RS01265 | 272653..273789 | + | 1137 | WP_000420837.1 | ISAs1 family transposase | ||
| Z_RS01270 | 273801..275552 | + | 1752 | pseudogene | RHS repeat protein | ||
| Z_RS01280 | 275754..276017 | + | 264 | WP_000247943.1 | hypothetical protein | ||
| Z_RS32110 | 275932..276117 | - | 186 | WP_120795385.1 | protein YncO |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0071 |
Z4049 (RpoS) | protein | Global regulator | Escherichia coli O157:H7 str. EDL933 | chromosome (NC_002655) | 3654380..3655372 (-) | 446003635 | Z1921 (KatN) (↓) |
| REG0072 |
Z5519 (OxyR) | protein | Global regulator | Escherichia coli O157:H7 str. EDL933 | chromosome (NC_002655) | 5033893..5034810 (+) | 446948683 | Z1921 (KatN) (↓) |
| REG0073 |
Z2013 (hns) | protein | Global regulator | Escherichia coli O157:H7 str. EDL933 | chromosome (NC_002655) | 1829490..1829903 (-) | 447210122 | Z0264 (hcp-2) (↑) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01453 |
Z1921 | Tse | - | Escherichia coli O157:H7 str. EDL933 | chromosome (NC_002655) | 1744916..1745806 (-) | 15801381 |
| EFF01452 |
Z5014 (Rhs-CT5) | Tde | IMU00343 |
Escherichia coli O157:H7 str. EDL933 | chromosome (NC_002655) | 4572113..4576246 (+) | 15804134 |
| EFF00020 |
Z0266 (Hcp2) | - | - | Escherichia coli O157:H7 str. EDL933 | chromosome (NC_002655) | 264134..264652 (+) | 447065702 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00343 |
Z5015 (CTI5) | EFF01452 |
Escherichia coli O157:H7 str. EDL933 | chromosome (NC_002655) | 4576267..4577109 (+) | 445994995 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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