Detailed information of Recipient susceptibility factor

Summary

ID	RSF000016
Strain	Escherichia coli BW25113 strain K-12
Replicon	chromosome
Sequence	Protein sequence (144 a.a.); Nucleotide sequence (432 bp)
Response to T6SS attack	protective
Known or putative function	Osmotic stress response
Description	The mutants with more-pronounced lysis, and then, competition assays with serial plating confirmed their survival was significantly reduced by the TseL-active T6SS-dependent killer
Reference	[1] Kamal F, Liang X, Manera K, et al. Differential Cellular Response to Translocated Toxic Effectors and Physical Penetration by the Type VI Secretion System. Cell Rep. 2020 Jun 16;31(11):107766. doi: 10.1016/j.celrep.2020.107766. PMID: 32553162 [2] Hersch SJ, Manera K, Dong TG. Defending against the Type Six Secretion System: beyond Immunity Genes. Cell Rep. 2020 Oct 13;33(2):108259. doi: 10.1016/j.celrep.2020.108259. PMID: 33053336

Experimental investigation has been performed.

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External database links

Locus tag (Gene)	BW25113_RS07770 (osmC)
Coordinates (Strand)	1550882..1551313 (+)
NCBI ID	446074450
RefSeq	NZ_CP009273
Uniprot ID	M9GIP1_ECOLX, A0A0E0Y2W7_ECO1C, K4W0F8_ECOLX, S1PAJ4_ECOLX, S1EMF8_ECOLX, L3Q5W5_ECOLX, L4JA19_ECOLX, U9Y183_ECOLX, U9XWC5_ECOLX, V0SN47_ECOLX, U9ZNT4_ECOLX, V0V849_ECOLX, V0Y7D7_ECOLX, V0A139_ECOLX, A0A029I3X9_ECOLX, D3GRL5_ECO44, E3PLY2_ECOH1, A7ZLS4_ECO24, A0A0E1SU26_ECOLX, B6IAN5_ECOSE, A0A140NAD7_ECOBD, J7RG96_ECOLX, D6IAI0_ECOLX, D6J9T0_ECOLX, A0A170UHT2_KLEOX, B7L7I1_ECO55, B7N4P4_ECOLU, A0A0H3MGY0_ECO7I, B7MUR5_ECO81, OSMC_SHIFL, A0A2A2XT07_SHIFL, A0A1H0HUF9_SHISO, A0A1X3JHJ6_ECOLX, A0A1X3L2S6_ECOLX, F4VF80_ECOLX, F4SIS0_ECOLX, A0A1X3I7A2_ECOLX, A0A0K9T634_ECOLX, F4SXY9_ECOLX, F4TFZ4_ECOLX, A0A1X3LJF7_ECOLX, A0A1X3LXJ5_ECOLX, A0A1X3J254_ECOLX, E6BQQ2_ECOLX, E1IT52_ECOLX, E1JCP8_ECOLX, D8ECT7_ECOLX, A0A0H3EHC5_ECO8N, A0A0E1LX64_ECOLX, D8ABI4_ECOMS, D7XVX2_ECOLX, D7Y0D3_ECOM1, E9T8V6_ECOLX, I4SHK5_ECOLX, OSMC_ECOLI, I2STA9_ECOLX, I2UGA3_ECOLX, I2WN09_ECOLX, A0A192C700_ECOLX, W8ZHU8_ECOLX, F0JQ61_ESCFE
KEGG ID	sfl:SF1743, eln:NRG857_07350, eum:ECUMN_1736, elh:ETEC_1552, sfx:S1876, eck:EC55989_1614, elo:EC042_1614, ecw:EcE24377A_1664, ebd:ECBD_2157, eco:b1482, sft:NCTC1_01889, esl:O3K_13085, ecj:JW1477, ecy:ECSE_1572, ecos:EC958_1750, ecq:ECED1_1634, ect:ECIAI39_1746
PDB ID	1QWI, 1NYE

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Pfam domain hit(s)

Domain	Pfam ID	E-value	Aligned region
OsmC	PF02566.21	3.6e-19	43..138

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Transmembrane helices

• Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-143	MTIHKKGQAHWEGDIKRGKGTVSTESGVLNQQPYGFNTRFEGEKGTNPEELIGAAHAACFSMALSLMLGEAGFTPTSIDTTADVSLDKVDAGFAITKIALKSEVAVPGIDASTFDGIIQKAKAGCPVSQVLKAEITLDYQLKS

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Signal peptides

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9601	-	-

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  Protein sequence: 144 a.a.    .Download


  Nucleotide sequence: 432 bp    .Download