Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00151  |
| T6SS type | Type i4a |
| Strain | Pseudomonas aeruginosa UCBPP-PA14 |
| Replicon (RefSeq) | chromosome (NC_008463) |
| Location | 3011563..3044708 |
| Function | anti-eukaryotic; virulence |
| Comment | Needed for full virulence in mouse lung and acute burn model; required for wild-type infection of Arabidopsis. |
| References | [1] Lesic B et al (2009) Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis. Microbiology. 155(Pt 9):2845-55. [PudMed:19497948] [2] Barret M et al (2011) Genomic analysis of the type VI secretion systems in Pseudomonas spp.: novel clusters and putative effectors uncovered. Microbiology. 157(Pt 6):1726-39. [PudMed:21474537] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | Sfa3 | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| PA14_RS13795 | 3007457..3007780 | + | 324 | WP_003089535.1 | transcriptional repressor | ||
| PA14_RS13800 | 3007822..3008742 | + | 921 | WP_003124571.1 | LysR family transcriptional regulator | ||
| PA14_RS13805 | 3008839..3009990 | + | 1152 | WP_003104946.1 | L-lactate dehydrogenase LldA | ||
| PA14_RS13810 | 3010057..3010299 | - | 243 | WP_003089526.1 | DUF1654 domain-containing protein | ||
| PA14_RS13815 | 3010594..3010830 | + | 237 | WP_003104944.1 | hypothetical protein | ||
| PA14_RS13820 | 3011096..3011566 | + | 471 | WP_003089521.1 | (2Fe-2S)-binding protein | ||
| PA14_RS13825 | 3011563..3013878 | + | 2316 | WP_003139301.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | ||
| PA14_RS13830 | 3014295..3015500 | - | 1206 | WP_003089517.1 | ABC transporter substrate-binding protein | ||
| PA14_RS13835 | 3015701..3016342 | - | 642 | WP_003139305.1 | response regulator transcription factor | ||
| PA14_RS13840 | 3016619..3017014 | + | 396 | WP_003089513.1 | DUF4280 domain-containing protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
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Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0166 | PA14_45960 (lasR) | protein | QS regulatory pathway | Pseudomonas aeruginosa UCBPP-PA14 | chromosome (NC_008463) | 4085339..4086058 (-) | 489173455 | TssA2 (PA14_43050) promotor (↓); HSI-III transcripts (↓); HSI-I transcripts (↑) |
| REG0167 | PA14_51340 (MvfR) | protein | QS regulatory pathway | Pseudomonas aeruginosa UCBPP-PA14 | chromosome (NC_008463) | 4562837..4563835 (+) | 489176730 | Upstream of pqs operon (↓); HSI-III transcripts (↓); HSI-I transcripts (↑) |
| REG0169 | PA14_22470 (PA3225) | protein | Global regulator | Pseudomonas aeruginosa UCBPP-PA14 | chromosome (NC_008463) | 1955624..1956553 (-) | 489182081 | PA14_00990 (TssA) promotor (↓); TssA1 (PA14_00990) transcript (↑); TssA2 (PA14_43050) transcript (↑); TssB3 (PA14_34070) transcript (↑) |
| REG0170 | PA14_20290 (AmrZ) | protein | Global regulator | Pseudomonas aeruginosa UCBPP-PA14 | chromosome (NC_008463) | 1747602..1747928 (-) | 489182353 | TssA1 (PA14_00990) promotor (↓); TssA2 (PA14_43050) promotor (↑); TssB3 (PA14_34070) promotor (↓) |
Showing 1 to 4 of 4 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01817 | PA14_03220 (VgrG2b) | Tpe | - | Pseudomonas aeruginosa UCBPP-PA14 | chromosome (NC_008463) | 285213..288272 (-) | 489228784 |
| EFF01822 | PA14_34030 (hcp3) | - | - | Pseudomonas aeruginosa UCBPP-PA14 | chromosome (NC_008463) | 3027086..3027583 (-) | 489180008 |
Showing 1 to 2 of 2 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| No matching records found | ||||||
Experimental investigation has been performed.
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||