Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00907  |
| T6SS type | Type iii |
| Strain | Bacteroides fragilis NCTC 9343 |
| Replicon (RefSeq) | chromosome (NC_003228) |
| Location | 2346972..2370693 |
| Function | anti-bacterial |
| Comment | Bacteroides fragilis targets B. thetaiotaomicron via T6SS; deletion of tssC in B. fragilis renders this species largely unable to reduce B. thetaiotaomicron growth. |
| References | [1] Russell AB et al (2014) A Type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism. Cell Host Microbe. 16(2):227-36. [PudMed:25070807] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssK | TssN | TssO | TssP |
| Number | 1 | 1 | 1 | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BF9343_RS09355 | 2344189..2344557 | - | 369 | 499302015 | hypothetical protein | ||
| BF9343_RS09360 | 2344598..2346970 | - | 2373 | 499302016 | type VI secretion system protein TssR | ||
| T6CP011043 | TssP | BF9343_RS09365 | 2346972..2347865 | - | 894 | 499302017 | PKD domain-containing protein |
| T6CP011327 | TssO | BF9343_RS09370 | 2347862..2348389 | - | 528 | 492268197 | type VI secretion system transmembrane protein TssO |
| T6CP011044 | TssO | BF9343_RS09375 | 2348402..2348905 | - | 504 | 492242849 | hypothetical protein |
| T6CP011045 | TssG | BF9343_RS09380 | 2348911..2349867 | - | 957 | 499302018 | type VI secretion system baseplate subunit TssG |
| T6CP011046 | TssK | BF9343_RS09385 | 2349869..2351011 | - | 1143 | 499302019 | hypothetical protein |
| T6CP011047 | TssN | BF9343_RS09390 | 2351039..2351887 | - | 849 | 499302020 | TssN family type VI secretion system protein |
| BF9343_RS09395 | 2352024..2352944 | - | 921 | 499302021 | hypothetical protein | ||
| BF9343_RS09400 | 2352949..2353995 | - | 1047 | 499302022 | hypothetical protein | ||
| BF9343_RS09405 | 2353982..2356975 | - | 2994 | 499302023 | hypothetical protein | ||
| T6CP011385 | PAAR | BF9343_RS09410 | 2356980..2357648 | - | 669 | 499302024 | PAAR domain-containing protein |
| T6CP011048 | TssI | BF9343_RS09415 | 2357670..2359520 | - | 1851 | 499302025 | hypothetical protein |
| T6CP011049 | TssF | BF9343_RS09420 | 2359546..2361363 | - | 1818 | 499302026 | type VI secretion system baseplate subunit TssF |
| T6CP011050 | TssE | BF9343_RS09425 | 2361394..2361834 | - | 441 | 492242900 | GPW/gp25 family protein |
| BF9343_RS09430 | 2361831..2362289 | - | 459 | 499302027 | DUF5456 family protein | ||
| T6CP011051 | TssD | BF9343_RS09435 | 2362294..2362713 | - | 420 | 496602435 | hypothetical protein |
| T6CP011052 | TssD | BF9343_RS09440 | 2362716..2363123 | - | 408 | 492242909 | hypothetical protein |
| BF9343_RS09445 | 2363137..2364114 | - | 978 | 492242912 | hypothetical protein | ||
| BF9343_RS09450 | 2364119..2364985 | - | 867 | 499302028 | hypothetical protein | ||
| T6CP011053 | TssD | BF9343_RS09455 | 2364997..2365404 | - | 408 | 492242918 | hypothetical protein |
| T6CP011054 | TssD | BF9343_RS09460 | 2365431..2365859 | - | 429 | 499302029 | hypothetical protein |
| T6CP011055 | TssH | BF9343_RS09465 | 2365875..2368358 | - | 2484 | 499302030 | ATP-dependent Clp protease ATP-binding subunit |
| T6CP011056 | TssC | BF9343_RS09470 | 2368371..2369750 | - | 1380 | 492268131 | type VI secretion system contractile sheath protein TssC |
| T6CP011057 | TssB | BF9343_RS09475 | 2369766..2370215 | - | 450 | 492242932 | hypothetical protein |
| T6CP011058 | TssD | BF9343_RS09480 | 2370304..2370693 | - | 390 | 492242937 | hypothetical protein |
| BF9343_RS09485 | 2371134..2371877 | - | 744 | 492242945 | TetR/AcrR family transcriptional regulator | ||
| BF9343_RS22485 | 2372037..2372213 | + | 177 | 499516024 | hypothetical protein | ||
| BF9343_RS09490 | 2372222..2373493 | + | 1272 | 499302032 | pyridoxal phosphate-dependent aminotransferase family protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01885 |
BF9343_1937 (bte1) | Tse | IMU00365 |
Bacteroides fragilis NCTC 9343 | chromosome (NC_003228) | 2364119..2364985 (-) | 60492942 |
| EFF01886 |
BF9343_1928 (bte2) | Tse | IMU00366 ; IMU00367 |
Bacteroides fragilis NCTC 9343 | chromosome (NC_003228) | 2353982..2356975 (-) | 60492933 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00365 |
BF9343_1936 (bti1) | EFF01885 |
Bacteroides fragilis NCTC 9343 | chromosome (NC_003228) | 2363137..2364114 (-) | 60492941 |
| IMU00366 |
BF9343_1926 (bti2b) | EFF01886 |
Bacteroides fragilis NCTC 9343 | chromosome (NC_003228) | 2352024..2352944 (-) | 60492931 |
| IMU00367 |
BF9343_1927 (bti2a) | EFF01886 |
Bacteroides fragilis NCTC 9343 | chromosome (NC_003228) | 2352949..2353995 (-) | 60492932 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|