Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01262  |
| T6SS type | Type i1 |
| Strain | Vibrio parahaemolyticus strain 12-297/B |
| Replicon (RefSeq) | chromosome (NZ_MYFG01000475) |
| Location | 22753..40086 |
| Function | anti-bacterial |
| Comment | V. parahaemolyticus 12-297/B T6SS1 is functional and mediates antibacterial activity under warm marine-like conditions in the presence of surface-sensing activation |
| References | [1] Biswanath Jana, Chaya M Fridman, Eran Bosis, Dor Salomon et al (2019) A Modular Effector With a DNase Domain and a Marker for T6SS Substrates. Nat Commun. 10(1):3595. [PudMed:31399579] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssE | TssF | TssG | TssJ | TssK | TssL | TssM |
| Number | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| B5C30_RS15310 | 18586..19578 | + | 993 | WP_025627540.1 | DUF2169 domain-containing protein | ||
| B5C30_RS15315 | 19571..20515 | + | 945 | WP_085577066.1 | hypothetical protein | ||
| B5C30_RS15320 | 20750..22753 | + | 2004 | WP_025575980.1 | protein kinase family protein | ||
| T6CP259643 | TssA | B5C30_RS15325 | 22753..24327 | + | 1575 | WP_085577067.1 | type VI secretion system protein TssA |
| T6CP259644 | TssB | B5C30_RS15330 | 24354..24860 | + | 507 | WP_005480589.1 | type VI secretion system contractile sheath small subunit |
| T6CP259645 | TssC | B5C30_RS15335 | 24869..26344 | + | 1476 | WP_031856269.1 | type VI secretion system contractile sheath large subunit |
| T6CP259646 | TssE | B5C30_RS15340 | 26406..26816 | + | 411 | WP_005480585.1 | type VI secretion system baseplate subunit TssE |
| T6CP259647 | TssF | B5C30_RS15345 | 26827..28575 | + | 1749 | WP_005480666.1 | type VI secretion system baseplate subunit TssF |
| T6CP259648 | TssG | B5C30_RS15350 | 28572..29570 | + | 999 | WP_025542747.1 | type VI secretion system baseplate subunit TssG |
| B5C30_RS15355 | 29634..30086 | - | 453 | WP_005480668.1 | Lrp/AsnC family transcriptional regulator | ||
| T6CP259649 | TssM | B5C30_RS15360 | 30119..33508 | - | 3390 | WP_085577068.1 | type VI secretion system membrane subunit TssM |
| T6CP259650 | TssA | B5C30_RS15365 | 33530..34825 | - | 1296 | WP_025533653.1 | type VI secretion system ImpA family N-terminal domain-containing protein |
| B5C30_RS15370 | 35345..35944 | + | 600 | WP_025541031.1 | hypothetical protein | ||
| B5C30_RS15375 | 35954..37468 | + | 1515 | WP_085577069.1 | FHA domain-containing protein | ||
| T6CP259651 | TssJ | B5C30_RS15380 | 37461..37961 | + | 501 | WP_011105829.1 | type VI secretion system lipoprotein TssJ |
| T6CP259652 | TssK | B5C30_RS15385 | 37973..39298 | + | 1326 | WP_005480714.1 | type VI secretion system baseplate subunit TssK |
| T6CP259653 | TssL | B5C30_RS15390 | 39295..40086 | + | 792 | WP_005495177.1 | type IVB secretion system protein IcmH/DotU |
| B5C30_RS15395 | 40236..40621 | + | 386 | WP_042775065.1 | DUF4150 domain-containing protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01530 |
V12_14465 (PoNe) | Tde | IMU00334 ; IMU00351 |
Vibrio parahaemolyticus strain 12-297/B C4271 | chromosome (NZ_MYFG01000470) | 18950..20299 (-) | 659039135 |
| EFF01533 |
V12_14465 (PoNe) | Tse | - | Vibrio parahaemolyticus strain 12-297/B C4271 | chromosome (NZ_MYFG01000470) | 17970..18953 (-) | 639578399 |
| EFF01829 |
B5C30_RS14470 (VgrG1b) | - | - | Vibrio parahaemolyticus strain 12-297/B C4271 | chromosome (NZ_MYFG01000470) | 20614..22692 (-) | 490886759 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00334 |
V12_14460 (PoNi) | EFF01530 |
Vibrio parahaemolyticus strain 12-297/B C4271 | chromosome (NZ_MYFG01000470) | 17970..18953 (-) | 639578399 |
| IMU00351 |
B5C30_RS14460 | EFF01530 |
Vibrio parahaemolyticus strain 12-297/B C4271 | chromosome (NZ_MYFG01000470) | 17970..18953 (-) | 639578399 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|