Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00080  |
| T6SS type | Type ii |
| Strain | Francisella tularensis subsp. tularensis SCHU S4 |
| Replicon (RefSeq) | chromosome (NC_006570) |
| Location | 1773260..1798375 |
| Function | anti-eukaryotic; effector translocation; virulence |
| Comment | - |
| References | [1] Broms JE et al (2012) Unique Substrates Secreted by the Type VI Secretion System of Francisella tularensis during Intramacrophage Infection. PLoS One. 7(11):e50473. [PudMed:23185631] [2] Nano FE et al (2007) The Francisella pathogenicity island. Ann N Y Acad Sci. 1105:122-37. [PudMed:17395722] [3] Long ME et al (2013) Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice, and reveals a unique phenotype for pdpC. Infect Immun. 81(3):850-61. [PudMed:23275090] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | IglC | IglD | IglE | IglF | IglG | IglH | IglI | IglJ | PdpA | PdpB | PdpC | PdpD | PdpE | TssB | TssC | TssI | TssL |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| T6CP005181 | PdpA | FTT_RS08990 | 1773260..1775722 | + | 2463 | WP_003022122.1 | hypothetical protein |
| T6CP005182 | PdpB | FTT_RS08995 | 1775727..1779008 | + | 3282 | WP_003022126.1 | hypothetical protein |
| T6CP005183 | IglE | FTT_RS09000 | 1778998..1779375 | + | 378 | WP_003022128.1 | hypothetical protein |
| T6CP005184 | TssI | FTT_RS09005 | 1779388..1779882 | + | 495 | WP_003016192.1 | hypothetical protein |
| T6CP005185 | IglF | FTT_RS09010 | 1779887..1781617 | + | 1731 | WP_003022130.1 | hypothetical protein |
| T6CP005186 | IglG | FTT_RS09015 | 1781618..1782139 | + | 522 | WP_003018233.1 | DUF4280 domain-containing protein |
| T6CP005187 | IglH | FTT_RS09020 | 1782152..1783582 | + | 1431 | WP_003022137.1 | hypothetical protein |
| T6CP005197 | TssL | FTT_RS09025 | 1783595..1784218 | + | 624 | WP_003016181.1 | DotU family type IV/VI secretion system protein |
| T6CP005196 | IglI | FTT_RS09030 | 1784240..1785391 | + | 1152 | WP_003016179.1 | hypothetical protein |
| T6CP005195 | IglJ | FTT_RS09035 | 1785357..1786130 | + | 774 | WP_003022141.1 | hypothetical protein |
| T6CP005194 | PdpC | FTT_RS09040 (pdpC) | 1786170..1790156 | + | 3987 | WP_003022143.1 | pathogenicity determinant protein PdpC |
| T6CP005193 | PdpE | FTT_RS09045 | 1790174..1790749 | + | 576 | WP_003022145.1 | hypothetical protein |
| T6CP005192 | IglD | FTT_RS09050 | 1790756..1791952 | - | 1197 | WP_003023944.1 | hypothetical protein |
| T6CP005191 | IglC | FTT_RS09055 | 1791973..1792602 | - | 630 | WP_014367985.1 | Intracellular growth locus subunit C |
| T6CP005190 | TssC | FTT_RS09060 (tssC) | 1792619..1794139 | - | 1521 | WP_003022151.1 | type VI secretion system contractile sheath large subunit |
| T6CP005189 | TssB | FTT_RS09065 (tssB) | 1794153..1794707 | - | 555 | WP_003022153.1 | type VI secretion system contractile sheath small subunit |
| T6CP005188 | PdpD | FTT_RS09070 | 1794788..1798375 | - | 3588 | WP_003022155.1 | hypothetical protein |
| FTT_RS09075 | 1798475..1799590 | - | 1116 | pseudogene | anhydro-N-acetylmuramic acid kinase | ||
| FTT_RS09080 | 1799825..1800634 | + | 810 | WP_075360614.1 | MFS transporter | ||
| FTT_RS09085 | 1800731..1801515 | - | 785 | WP_004578540.1 | IS630-like element ISFtu1 family transposase | ||
| FTT_RS09095 | 1801577..1802095 | - | 519 | pseudogene | DNA cytosine methyltransferase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF00108 |
FTT_1347 (VgrG) | - | - | Francisella tularensis subsp. tularensis SCHU S4 | chromosome (NC_006570) | 1779388..1779882 (+) | 56708711 |
| EFF00109 |
FTL_0118 (IglI) | - | - | Francisella tularensis subsp. tularensis SCHU S4 | chromosome (NC_006570) | 1784240..1785391 (+) | 56708716 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| ACP00019 |
FTT_0682c (fipB/dsbA) | structure affiliated protein | Francisella tularensis subsp. tularensis SCHU S4 | chromosome (NC_006570) | 699171..700016 (-) | 56707802 | FTT_1713c (IglB2); FTT_1712c (IglC2) | - |