Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00080 experimental
T6SS type Type ii
Strain Francisella tularensis subsp. tularensis SCHU S4
Replicon (RefSeq) chromosome (NC_006570)
Location 1773260..1798375
Function anti-eukaryotic; effector translocation; virulence
Comment -
References
[1] Broms JE et al (2012) Unique Substrates Secreted by the Type VI Secretion System of Francisella tularensis during Intramacrophage Infection. PLoS One. 7(11):e50473. [PudMed:23185631]
[2] Nano FE et al (2007) The Francisella pathogenicity island. Ann N Y Acad Sci. 1105:122-37. [PudMed:17395722]
[3] Long ME et al (2013) Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice, and reveals a unique phenotype for pdpC. Infect Immun. 81(3):850-61. [PudMed:23275090]
[4] Long ME et al (2013) Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice, and reveals a unique phenotype for pdpC. Infect Immun. 81(3):850-61. [PudMed:23275090]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentIglCIglDIglEIglFIglGIglHIglIIglJPdpAPdpBPdpCPdpDPdpETssBTssCTssITssL
Number11111111111111111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
T6CP005181 PdpA FTT_RS08990 1773260..1775722 + 2463 WP_003022122.1 hypothetical protein
T6CP005182 PdpB FTT_RS08995 1775727..1779008 + 3282 WP_003022126.1 hypothetical protein
T6CP005183 IglE FTT_RS09000 1778998..1779375 + 378 WP_003022128.1 hypothetical protein
T6CP005184 TssI FTT_RS09005 1779388..1779882 + 495 WP_003016192.1 hypothetical protein
T6CP005185 IglF FTT_RS09010 1779887..1781617 + 1731 WP_003022130.1 hypothetical protein
T6CP005186 IglG FTT_RS09015 1781618..1782139 + 522 WP_003018233.1 DUF4280 domain-containing protein
T6CP005187 IglH FTT_RS09020 1782152..1783582 + 1431 WP_003022137.1 hypothetical protein
T6CP005197 TssL FTT_RS09025 1783595..1784218 + 624 WP_003016181.1 DotU family type IV/VI secretion system protein
T6CP005196 IglI FTT_RS09030 1784240..1785391 + 1152 WP_003016179.1 hypothetical protein
T6CP005195 IglJ FTT_RS09035 1785357..1786130 + 774 WP_003022141.1 hypothetical protein
T6CP005194 PdpC FTT_RS09040 (pdpC) 1786170..1790156 + 3987 WP_003022143.1 pathogenicity determinant protein PdpC
T6CP005193 PdpE FTT_RS09045 1790174..1790749 + 576 WP_003022145.1 hypothetical protein
T6CP005192 IglD FTT_RS09050 1790756..1791952 - 1197 WP_003023944.1 hypothetical protein
T6CP005191 IglC FTT_RS09055 1791973..1792602 - 630 WP_014367985.1 Intracellular growth locus subunit C
T6CP005190 TssC FTT_RS09060 (tssC) 1792619..1794139 - 1521 WP_003022151.1 type VI secretion system contractile sheath large subunit
T6CP005189 TssB FTT_RS09065 (tssB) 1794153..1794707 - 555 WP_003022153.1 type VI secretion system contractile sheath small subunit
T6CP005188 PdpD FTT_RS09070 1794788..1798375 - 3588 WP_003022155.1 hypothetical protein
FTT_RS09075 1798475..1799590 - 1116 pseudogene anhydro-N-acetylmuramic acid kinase
FTT_RS09080 1799825..1800634 + 810 WP_075360614.1 MFS transporter
FTT_RS09085 1800731..1801515 - 785 WP_004578540.1 IS630-like element ISFtu1 family transposase
FTT_RS09095 1801577..1802095 - 519 pseudogene DNA cytosine methyltransferase
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
EFF00108 experimental FTT_1347 (VgrG) - - Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 1779388..1779882 (+) 56708711
EFF00109 experimental FTL_0118 (IglI) - - Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 1784240..1785391 (+) 56708716

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector
ACP00019 experimental FTT_0682c (fipB/dsbA) structure affiliated protein Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 699171..700016 (-) 56707802 FTT_1713c (IglB2); FTT_1712c (IglC2) -