Detailed information of component protein


Summary

Component ID T6CP005187
Component protein type IglH
T6SS ID (Type) T6SS00080 experimental (Type ii)
Strain Francisella tularensis subsp. tularensis SCHU S4
Replicon chromosome
Sequence Protein sequence (477 a.a.); Nucleotide sequence (1431 bp)
Reference
[1] Bröms JE, Meyer L, Sun K, et al. Unique substrates secreted by the type VI secretion system of Francisella tularensis during intramacrophage infection. PLoS One. 2012;7(11):e50473. doi: 10.1371/journal.pone.0050473. Epub 2012 Nov 20. PMID: 23185631
[2] Nano FE, Schmerk C. The Francisella pathogenicity island. Ann N Y Acad Sci. 2007 Jun;1105:122-37. Epub 2007 Mar 29. PMID: 17395722
[3] Long ME, Lindemann SR, Rasmussen JA, et al. Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC. Infect Immun. 2013 Mar;81(3):850-61. doi: 10.1128/IAI.00822-12. Epub 2012 Dec 28. PMID: 23275090
[4] Long ME, Lindemann SR, Rasmussen JA, et al. Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC. Infect Immun. 2013 Mar;81(3):850-61. doi: 10.1128/IAI.00822-12. Epub 2012 Dec 28. PMID: 23275090
experimental Experimental investigation has been performed on this T6SS

External database links

Locus tag (Gene) FTT_RS09020
Coordinate (Strand) 1782152..1783582 (+)
NCBI ID WP_003022137.1
RefSeq NC_006570
Uniprot ID A0A3N3ZXU8_FRATU, A0A6N3SE05_FRATT, Q5NED2_FRATT
KEGG ID ftu:FTT_1350, ftu:FTT_1705
PDB ID -

Pfam domain hit(s)

Domain Pfam ID E-value Aligned region

Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Outside 1-476 MDEKRKDLSTNDASILKKTFDKLSNDIRDDFDKRIFDYSNALLFKYYSNLYYFIPKSCLLEISDKGHNGYYIPPQEYFFIEDKRTGKTLTYTTKSENIILPIRDITTIKQSDTSINISLEFANNFDYDYVTIWIDPTLCKEDPSFATYIFNQVLEDNGSAKIKFSNHSYTTKNVQIEPIKFQLKPTEKLVLNIHSPSLLYGFNIKIKDLFKYKNNDLNKIDFFLEVKTENHNDEKLSSLFRVNLIPVFNSFDDYSSTSFASMNLSESKLKHHQKDDAQAIEVLSVYENNKQCDFNSFLFVGQNEYYFNRSTQSLNYSSVLPQFSNKIIGTKIHTYTTWTQITEISDLIEINSNAIASISCNISPIVINKALNNYNSNAKEMFNIIDMIISKNMYSKTTLLAIAKLLKINTNDLTLLSMLLQDVEMDSTINELILTLSDKYNPKYKHFLNFHIGIICKFINQNTFSFIKKIVLNNSI



Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9896 - -



  Protein sequence: 477 a.a.    

>T6CP005187 NC_006570:1782152-1783582 [Francisella tularensis subsp. tularensis SCHU S4] [IglH]
MDEKRKDLSTNDASILKKTFDKLSNDIRDDFDKRIFDYSNALLFKYYSNLYYFIPKSCLLEISDKGHNGYYIPPQEYFFI
EDKRTGKTLTYTTKSENIILPIRDITTIKQSDTSINISLEFANNFDYDYVTIWIDPTLCKEDPSFATYIFNQVLEDNGSA
KIKFSNHSYTTKNVQIEPIKFQLKPTEKLVLNIHSPSLLYGFNIKIKDLFKYKNNDLNKIDFFLEVKTENHNDEKLSSLF
RVNLIPVFNSFDDYSSTSFASMNLSESKLKHHQKDDAQAIEVLSVYENNKQCDFNSFLFVGQNEYYFNRSTQSLNYSSVL
PQFSNKIIGTKIHTYTTWTQITEISDLIEINSNAIASISCNISPIVINKALNNYNSNAKEMFNIIDMIISKNMYSKTTLL
AIAKLLKINTNDLTLLSMLLQDVEMDSTINELILTLSDKYNPKYKHFLNFHIGIICKFINQNTFSFIKKIVLNNSI*

  Nucleotide sequence: 1431 bp    

>T6CP005187 NC_006570:1782152-1783582 [Francisella tularensis subsp. tularensis SCHU S4] [IglH]
ATGGATGAAAAAAGAAAAGATTTAAGTACGAATGATGCTAGCATCCTAAAAAAAACTTTTGACAAACTAAGTAATGATAT
AAGAGATGATTTTGATAAGAGAATTTTTGATTATAGTAATGCTCTTTTATTCAAGTATTATAGTAACCTTTATTATTTCA
TTCCTAAATCATGCTTATTAGAAATAAGTGATAAAGGACACAATGGTTACTATATTCCGCCTCAGGAATATTTTTTCATA
GAAGACAAGAGAACAGGTAAAACTCTAACATATACGACAAAGTCAGAAAATATAATACTCCCTATTAGAGATATCACAAC
CATAAAACAAAGTGATACATCAATAAATATATCATTGGAATTTGCAAATAACTTTGACTATGATTATGTTACTATCTGGA
TAGATCCAACTTTATGTAAAGAAGATCCTAGCTTTGCCACATACATATTTAACCAAGTATTAGAAGATAATGGCTCAGCA
AAGATTAAATTTTCAAATCATAGTTATACAACAAAAAATGTACAAATAGAACCAATTAAGTTCCAATTAAAACCAACAGA
AAAATTAGTTCTCAATATCCATTCTCCTAGCCTTTTATATGGTTTTAACATAAAGATCAAAGACTTATTTAAATACAAAA
ATAATGACCTCAACAAAATTGACTTTTTTTTAGAAGTTAAAACTGAAAACCATAATGACGAAAAATTATCATCTCTATTT
AGAGTTAATTTAATACCTGTGTTTAATAGTTTTGATGATTACTCAAGCACCTCATTTGCTTCGATGAATCTCTCAGAGAG
TAAACTAAAACATCATCAAAAAGATGATGCTCAAGCAATAGAAGTATTATCTGTTTATGAGAATAATAAACAATGTGATT
TTAATAGTTTTCTTTTTGTAGGACAGAATGAGTATTATTTTAATCGCAGCACACAATCTTTAAATTATAGTAGCGTACTC
CCTCAATTTAGTAATAAAATAATAGGAACAAAAATACATACATATACAACCTGGACACAGATAACTGAGATTTCTGATCT
AATTGAAATTAACTCAAATGCAATAGCATCTATAAGCTGTAATATTTCTCCAATAGTTATTAACAAAGCACTAAACAACT
ACAATAGCAATGCTAAAGAAATGTTTAATATAATAGATATGATCATCTCTAAGAATATGTATTCAAAAACAACACTCCTA
GCTATAGCAAAGCTTTTAAAGATTAATACTAATGACTTAACTTTACTATCAATGCTCCTACAAGATGTTGAGATGGACTC
TACTATAAATGAGCTAATTTTAACCTTAAGTGATAAATATAACCCAAAATATAAACATTTCTTAAATTTTCATATTGGTA
TTATATGCAAATTTATAAATCAAAACACCTTTAGCTTTATTAAAAAGATTGTTTTAAATAACTCTATATAA