Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS17510  |
| T6SS type | Type Unknown |
| Strain | Burkholderia glumae BGR1 |
| Replicon (RefSeq) | chromosome II (NC_012721) |
| Location | 878998..900488 |
| Function | anti-eukaryotic |
| Comment | We found that both T6SS group_4 and group_5, belonging to the eukaryotic targeting system, act independently as bacterial virulence factors toward host plants. |
| References | [1] Kim N, Kim JJ, Kim I, Mannaa M, Park J, Kim J, Lee HH, Lee SB, Park DS, Sul WJ, Seo YS. et al (2020) Type VI secretion systems of plant-pathogenic Burkholderia glumae BGR1 play a functionally distinct role in interspecies interactions and virulence.. Mol Plant Pathol. 21(8):1055-1069. [PudMed:32643866] [2] Kim N, Han G, Jung H, Lee HH, Park J, Seo YS. et al (2021) T6SS Accessory Proteins, Including DUF2169 Domain-Containing Protein and Pentapeptide Repeats Protein, Contribute to Bacterial Virulence in T6SS Group_5 of Burkholderia glumae BGR1.. Plants (Basel). 11(1). [PudMed:35009038] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssC | TssD | TssE | TssF | TssG | TssI | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BGLU_RS21440 | 874171..875142 | + | 972 | WP_012733546.1 | sigma 54-interacting transcriptional regulator | ||
| BGLU_RS21445 | 875206..875442 | + | 237 | WP_017425208.1 | hypothetical protein | ||
| BGLU_RS21450 | 875471..875749 | - | 279 | WP_017432332.1 | hypothetical protein | ||
| BGLU_RS21455 | 875880..876251 | + | 372 | WP_148271055.1 | hypothetical protein | ||
| BGLU_RS21460 | 876310..876726 | - | 417 | WP_017425017.1 | hypothetical protein | ||
| BGLU_RS21465 | 876842..877177 | - | 336 | WP_017432330.1 | hypothetical protein | ||
| BGLU_RS35585 | 877488..877808 | + | 321 | WP_153478680.1 | hypothetical protein | ||
| BGLU_RS21470 | 877849..878967 | - | 1119 | WP_017425021.1 | GNAT family N-acetyltransferase | ||
| T6CP259633 | TssA | BGLU_RS21475 (tssA) | 878998..880143 | - | 1146 | WP_012733547.1 | type VI secretion system protein TssA |
| T6CP259634 | TssM | BGLU_RS21480 | 880140..884159 | - | 4020 | WP_012733548.1 | type VI secretion protein |
| T6CP259635 | TssL | BGLU_RS21485 | 884185..884964 | - | 780 | WP_012733549.1 | DotU family type IV/VI secretion system protein |
| BGLU_RS21490 (tssK) | 884957..886357 | - | 1401 | WP_017423034.1 | type VI secretion system baseplate subunit TssK | ||
| BGLU_RS21495 | 886446..886916 | - | 471 | WP_012733551.1 | hypothetical protein | ||
| BGLU_RS21500 | 886920..887318 | - | 399 | WP_012733552.1 | DUF4150 domain-containing protein | ||
| BGLU_RS21505 | 887357..887911 | - | 555 | WP_012733553.1 | DUF3540 domain-containing protein | ||
| BGLU_RS21510 | 887911..888981 | - | 1071 | WP_012733554.1 | pentapeptide repeat-containing protein | ||
| BGLU_RS21515 | 888978..891614 | - | 2637 | WP_012733555.1 | DUF2169 domain-containing protein | ||
| T6CP259637 | TssI | BGLU_RS21520 | 891621..894263 | - | 2643 | WP_012733556.1 | type IV secretion protein Rhs |
| T6CP259638 | TssG | BGLU_RS21525 (tssG) | 894260..895399 | - | 1140 | WP_080569382.1 | type VI secretion system baseplate subunit TssG |
| T6CP259639 | TssF | BGLU_RS21535 (tssF) | 895419..897269 | - | 1851 | WP_012733558.1 | type VI secretion system baseplate subunit TssF |
| T6CP259640 | TssE | BGLU_RS21540 (tssE) | 897277..897654 | - | 378 | WP_012733559.1 | type VI secretion system baseplate subunit TssE |
| T6CP259641 | TssD | BGLU_RS21545 | 897718..898275 | - | 558 | WP_012733560.1 | type VI secretion system tube protein Hcp |
| T6CP259642 | TssC | BGLU_RS21550 (tssC) | 898308..900488 | - | 2181 | WP_012733561.1 | type VI secretion system contractile sheath large subunit |
| BGLU_RS21555 | 901520..904822 | + | 3303 | WP_012733562.1 | efflux RND transporter permease subunit |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF76653 |
BGLU_RS23285 | - | - | Burkholderia glumae BGR1 | chromosome (NC_012721) | 897718..898275 (-) | WP_012733560.1 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| ACP44070 |
BGLU_RS21515 | adaptor | Burkholderia glumae BGR1 | chromosome (NC_012721) | 888978..891614 (-) | WP_012733555.1 | - | - |