Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00611  |
| T6SS type | Type i3 |
| Strain | Pseudomonas aeruginosa M18 |
| Replicon (RefSeq) | chromosome (NC_017548) |
| Location | 89946..115973 |
| Function | - |
| Comment | - |
| References | [1] Wei X et al (2013) Global control of GacA on secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium Pseudomonas aeruginosa M18. J Bacteriol. 195(15):3387-400. [PudMed:23708134] |
Bioinformatics investigation has been performed.T6SS components and genome coordinates
| Component | FHA | PppA | TagF | TagJ | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| PAM18_RS00380 (ppkA) | 85424..88523 | - | 3100 | pseudogene | serine/threonine protein kinase PpkA | ||
| T6CP012532 | PppA | PAM18_RS00385 (pppA) | 88531..89259 | - | 729 | WP_003106965.1 | serine/threonine phosphatase PppA |
| T6CP012533 | TagF | PAM18_RS00390 (tagF) | 89269..89949 | - | 681 | WP_003083642.1 | type VI secretion system-associated protein TagF |
| T6CP006439 | TssM | PAM18_RS00395 (tssM) | 89946..93476 | - | 3531 | WP_009875647.1 | type VI secretion system membrane subunit TssM |
| T6CP006440 | TssL | PAM18_RS00400 | 93473..94822 | - | 1350 | WP_003118500.1 | DotU family type VI secretion system protein |
| T6CP006441 | TssK | PAM18_RS00405 (tssK) | 94829..96163 | - | 1335 | WP_003115052.1 | type VI secretion system baseplate subunit TssK |
| T6CP006442 | TssJ | PAM18_RS00410 (tssJ) | 96179..96643 | - | 465 | WP_004351964.1 | type VI secretion system lipoprotein TssJ |
| T6CP012072 | FHA | PAM18_RS00415 (tagH) | 96688..98205 | - | 1518 | WP_014602337.1 | type VI secretion system-associated FHA domain protein TagH |
| T6CP006443 | TssA | PAM18_RS00420 (tssA) | 98573..99607 | + | 1035 | WP_014602338.1 | type VI secretion system protein TssA |
| T6CP006444 | TssB | PAM18_RS00425 (tssB) | 99696..100214 | + | 519 | WP_003083666.1 | type VI secretion system contractile sheath small subunit |
| T6CP006445 | TssC | PAM18_RS00430 (tssC) | 100227..101723 | + | 1497 | WP_003104973.1 | type VI secretion system contractile sheath large subunit |
| T6CP006446 | TssD | PAM18_RS00435 (hcp) | 101799..102287 | + | 489 | WP_003083670.1 | type VI secretion system receptor/chaperone Hcp |
| T6CP012839 | TagJ | PAM18_RS00440 (tagJ) | 102455..103300 | + | 846 | WP_003119488.1 | type VI secretion system accessory protein TagJ |
| T6CP006447 | TssE | PAM18_RS00445 (tssE) | 103302..103811 | + | 510 | WP_003104971.1 | type VI secretion system baseplate subunit TssE |
| T6CP006448 | TssF | PAM18_RS00450 (tssF) | 103808..105667 | + | 1860 | WP_003083676.1 | type VI secretion system baseplate subunit TssF |
| T6CP006449 | TssG | PAM18_RS00455 (tssG) | 105631..106677 | + | 1047 | WP_003104969.1 | type VI secretion system baseplate subunit TssG |
| T6CP006450 | TssH | PAM18_RS00460 (tssH) | 106670..109378 | + | 2709 | WP_014602339.1 | type VI secretion system ATPase TssH |
| T6CP006451 | TssI | PAM18_RS00465 (vgrG1a) | 109425..111356 | + | 1932 | WP_003142374.1 | type VI secretion system spike protein VgrG1a |
| PAM18_RS00470 | 111471..111755 | - | 285 | WP_003104961.1 | hypothetical protein | ||
| PAM18_RS00475 | 111752..113044 | - | 1293 | WP_003104959.1 | PAAR domain-containing protein | ||
| PAM18_RS00480 | 113060..113494 | - | 435 | WP_003083692.1 | DcrB-related protein | ||
| T6CP006452 | TssI | PAM18_RS00485 (vgrG1b) | 113748..115973 | + | 2226 | WP_004346969.1 | type VI secretion system spike protein VgrG1b |
| PAM18_RS00490 | 116001..116450 | + | 450 | WP_003101196.1 | hypothetical protein | ||
| PAM18_RS00495 | 116380..117579 | + | 1200 | WP_003123798.1 | DUF2169 domain-containing protein | ||
| PAM18_RS00500 | 117576..118613 | + | 1038 | WP_003115088.1 | 3-oxoacyl-ACP synthase | ||
| PAM18_RS00505 | 118613..119773 | + | 1161 | WP_003083698.1 | DUF4150 domain-containing protein | ||
| PAM18_RS00510 | 119795..120715 | + | 921 | WP_003115069.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0253 |
PAM18_RS12360 (gacA) | protein | TCS-RR | Pseudomonas aeruginosa M18 | chromosome (NC_017548) | 2625815..2626459 (+) | 489180874 | hsiA1 operon transcript (↓); hsiA2 operon transcript (↓); hsiA3 operon transcript (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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