Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00945  |
| T6SS type | Type i1 |
| Strain | Vibrio proteolyticus NBRC 13287 |
| Replicon (RefSeq) | chromosome II (NZ_BATJ01000006) |
| Location | 17401..46675 |
| Function | anti-bacterial; anti-eukaryotic |
| Comment | Vpr kills competing bacteria mediated by T6SS1 and induces hemolysin‐independent morphological changes in macrophages.Vpr uses the T6SS1 MIX‐effector Vpr01570 to manipulate actin in macrophages. |
| References | [1] Ann Ray, Nika Schwartz, Marcela de Souza Santos, Junmei Zhang, Kim Orth, Dor Salomon et al (2017) Type VI Secretion System MIX-effectors Carry Both Antibacterial and Anti-Eukaryotic Activities. EMBO Rep.. 18(11):1978-1990. [PudMed:28912123] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| VPR01S_RS08800 | 15783..17414 | - | 1632 | 545468469 | sigma-54-dependent Fis family transcriptional regulator | ||
| T6CP015946 | TssH | VPR01S_RS08805 (tssH) | 17401..20064 | - | 2664 | 545468470 | type VI secretion system ATPase TssH |
| T6CP015947 | TssD | VPR01S_RS08810 | 20528..21046 | + | 519 | 545468471 | Hcp family type VI secretion system effector |
| T6CP015948 | TssI | VPR01S_RS08815 (tssI) | 21119..23197 | + | 2079 | 545468472 | type VI secretion system tip protein VgrG |
| VPR01S_RS08820 | 23197..23691 | + | 495 | 545468473 | hypothetical protein | ||
| VPR01S_RS08825 | 23721..25040 | + | 1320 | 545468474 | hypothetical protein | ||
| VPR01S_RS08830 | 25021..26013 | + | 993 | 545468475 | DUF2169 domain-containing protein | ||
| VPR01S_RS08835 | 26010..26957 | + | 948 | 545468476 | hypothetical protein | ||
| VPR01S_RS08840 | 27203..29197 | + | 1995 | 545468477 | protein kinase | ||
| T6CP015949 | TssA | VPR01S_RS08845 (tssA) | 29200..30753 | + | 1554 | 545468478 | type VI secretion system protein TssA |
| T6CP015950 | TssB | VPR01S_RS08850 (tssB) | 30780..31289 | + | 510 | 545468479 | type VI secretion system contractile sheath small subunit |
| T6CP015951 | TssC | VPR01S_RS08855 (tssC) | 31299..32777 | + | 1479 | 545468480 | type VI secretion system contractile sheath large subunit |
| T6CP015952 | TssE | VPR01S_RS08860 (tssE) | 32841..33251 | + | 411 | 545468481 | type VI secretion system baseplate subunit TssE |
| T6CP015953 | TssF | VPR01S_RS08865 (tssF) | 33270..35018 | + | 1749 | 545468482 | type VI secretion system baseplate subunit TssF |
| T6CP015954 | TssG | VPR01S_RS08870 (tssG) | 35015..36013 | + | 999 | 545468483 | type VI secretion system baseplate subunit TssG |
| VPR01S_RS08875 | 36051..36503 | - | 453 | 750620619 | Lrp/AsnC family transcriptional regulator | ||
| T6CP015955 | TssM | VPR01S_RS08880 (tssM) | 36549..39941 | - | 3393 | 750620620 | type VI secretion system membrane subunit TssM |
| T6CP015956 | TssA | VPR01S_RS08885 | 39976..41328 | - | 1353 | 545468486 | type VI secretion system ImpA family N-terminal domain-containing protein |
| VPR01S_RS08890 | 41933..42535 | + | 603 | 545468487 | outer membrane beta-barrel protein | ||
| VPR01S_RS08895 | 42546..44057 | + | 1512 | 545468488 | FHA domain-containing protein | ||
| T6CP015957 | TssJ | VPR01S_RS08900 (tssJ) | 44050..44550 | + | 501 | 545468489 | type VI secretion system lipoprotein TssJ |
| T6CP015958 | TssK | VPR01S_RS08905 (tssK) | 44562..45887 | + | 1326 | 545468490 | type VI secretion system baseplate subunit TssK |
| T6CP015959 | TssL | VPR01S_RS08910 | 45884..46675 | + | 792 | 750620622 | type IVB secretion system protein IcmH/DotU |
| VPR01S_RS08920 | 47197..47877 | + | 681 | 545468492 | MaoC family dehydratase | ||
| VPR01S_RS08925 | 47930..48745 | - | 816 | 545468493 | phosphate ABC transporter substrate-binding protein | ||
| VPR01S_RS08930 | 48943..49293 | + | 351 | 545468494 | DUF3024 domain-containing protein | ||
| VPR01S_RS08935 (rnb) | 49356..51368 | - | 2013 | 545468495 | exoribonuclease II |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01524 |
VPR01S_11_01570 | DddA | - | Vibrio proteolyticus NBRC 13287 | chromosome (BATJ01000011) | 161248..163059 (+) | 543441460 |
| EFF01800 |
VPR01S_RS21945 | Tde | - | Vibrio proteolyticus NBRC 13287 | chromosome (NZ_BATJ01000004) | 229175..229945 (-) | 545468119 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|