Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00942  |
| T6SS type | Type Unknown |
| Strain | Escherichia coli strain PE027 |
| Replicon (GenBank) | chromosome I (KX118287) |
| Location | 1..7577 |
| Function | anti-bacterial |
| Comment | Wt-PE027 inhibited recipient cells by more than 100-fold compared with △CT3 and △T6SS2 (a ClpV2 mutant). |
| References | [1] Ma J, Sun M, Dong W, Pan Z, Lu C, Yao H et al (2017) PAAR-Rhs proteins harbor various C-terminal toxins to diversify the antibacterial pathways of type VI secretion systems. Environ Microbiol. (1):345-360. [PudMed:27871130] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | Ct3A | Ct3B | Ct3C | Ct3D |
| Number | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| T6CP016146 | Ct3A | Locus_01 (ct3A) | 1..1902 | + | 1902 | 1062685075 | orphan Vgr family protein |
| T6CP016147 | Ct3B | Locus_02 (ct3B) | 1930..2391 | + | 462 | 1062685076 | DUF1795 protein |
| T6CP016148 | Ct3C | Locus_03 (ct3C) | 2411..7210 | + | 4800 | 1062685077 | Rhs core protein |
| T6CP016149 | Ct3D | Locus_04 (ct3D) | 7212..7577 | + | 366 | 1062685078 | immunity protein of restriction endonuclease 3 toxin |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01519 |
ECO111_0594 (Rhs-CT3) | Tde | IMU00342 |
Escherichia coli strain PE027 | chromosome (NC_013364) | 632578..637377 (-) | 447211780 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|