Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00788  |
| T6SS type | Type i1 |
| Strain | Aeromonas dhakensis strain SSU |
| Replicon (RefSeq) | chromosome (NZ_JH815591) |
| Location | 1017876..1061054 |
| Function | anti-eukaryotic; effector translocation; virulence |
| Comment | Cytotoxicity and inhibition of phagocytosis in cultured macrophages and epithelial cells; full virulence in septicaemic mouse model. |
| References | [1] Suarez G et al (2008) Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila. Microb Pathog. 44(4):344-61. [PudMed:18037263] [2] Suarez G et al (2010) Role of Hcp, a type 6 secretion system effector, of Aeromonas hydrophila in modulating activation of host immune cells. Microbiology. 156(Pt 12):3678-88. [PudMed:20798163] [3] Grim CJ et al (2014) Functional Genomic Characterization of Virulence Factors from Necrotizing Fasciitis-Causing Strains of Aeromonas hydrophila. Appl Environ Microbiol. 80(14):4162-83. [PudMed:24795370] [4] Suarez G et al (2010) A type VI secretion system effector protein, VgrG1, from Aeromonas hydrophila that induces host cell toxicity by ADP ribosylation of actin. J Bacteriol. 192(1):155-68. [PudMed:19880608] [5] Sha J et al (2013) Evaluation of the roles played by Hcp and VgrG type 6 secretion system effectors in Aeromonas hydrophila SSU pathogenesis. Microbiology. 159(Pt 6):1120-35. [PudMed:23519162] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 |
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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| HMPREF1171_RS04660 | 1014366..1014947 | + | 582 | WP_005299956.1 | thymidine kinase | ||
| HMPREF1171_RS04665 | 1015016..1016353 | - | 1338 | WP_005299958.1 | flavohemoglobin expression-modulating QEGLA motif protein | ||
| HMPREF1171_RS04670 | 1016512..1016967 | + | 456 | WP_005299960.1 | YbjN domain-containing protein | ||
| T6CP010911 | TssD | HMPREF1171_RS04680 (hcp1) | 1017876..1018309 | + | 434 | WP_005299962.1 | type VI secretion system effector Hcp1 |
| HMPREF1171_RS04685 (hcp1) | 1018410..1018589 | + | 180 | pseudogene | type VI secretion system effector Hcp1 | ||
| T6CP010912 | TssI | HMPREF1171_RS04690 | 1019048..1021076 | + | 2029 | WP_005299968.1 | type VI secretion system tip protein VgrG |
| HMPREF1171_RS04695 | 1021066..1021794 | + | 729 | WP_005299970.1 | DUF4123 domain-containing protein | ||
| HMPREF1171_RS04700 | 1021791..1026428 | + | 4638 | WP_005299972.1 | DUF6531 domain-containing protein | ||
| HMPREF1171_RS23520 | 1026425..1026889 | + | 465 | WP_154956505.1 | hypothetical protein | ||
| HMPREF1171_RS23525 | 1026961..1027392 | + | 432 | WP_154956506.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
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Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0254 | HMPREF1171_RS04760 | protein | Transcription regulator | Aeromonas dhakensis strain SSU | chromosome (NZ_JH815591) | 1041366..1042904 (+) | WP_005299999.1 | hcp expression (↓) |
| REG0255 | HMPREF1171_RS20340 | protein | QS regulatory pathway | Aeromonas dhakensis strain SSU | chromosome (NZ_JH815591) | 4528194..4528817 (-) | WP_005308454.1 | ahyR (↓) |
| REG0256 | HMPREF1171_RS20345 | protein | QS regulatory pathway | Aeromonas dhakensis strain SSU | chromosome (NZ_JH815591) | 4528880..4529662 (+) | WP_005308457.1 | hcp and vgrG2 expression (↓) |
Showing 1 to 3 of 3 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01888 | HMPREF1171_RS04800 (TseP) | Tpe | IMU17302 | Aeromonas dhakensis strain SSU | chromosome (NZ_JH815591) | 1054604..1055227 (+) | WP_029305891.1 |
| EFF18622 | HMPREF1171_RS04700 (TseI) | Tde | IMU17301 | Aeromonas dhakensis strain SSU | chromosome (NZ_JH815591) | 1021791..1026428 (+) | WP_005299972.1 |
| EFF76650 | HMPREF1171_RS12055 (tseC) | Tse | IMU00361 | Aeromonas dhakensis strain SSU | chromosome (NZ_JH815591) | 2753469..2756654 (-) | WP_005303625.1 |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00361 | HMPREF1171_RS12050 (tsiC) | EFF76650 | Aeromonas dhakensis strain SSU | chromosome (NZ_JH815591) | 2752679..2753485 (-) | WP_005303621.1 |
| IMU17301 | HMPREF1171_RS04705 (TsiI) | EFF18622 | Aeromonas dhakensis strain SSU | chromosome (NZ_JH815591) | 1027446..1028828 (+) | WP_005299974.1 |
| IMU17302 | HMPREF1171_RS23530 | EFF01888 | Aeromonas dhakensis strain SSU | chromosome (NZ_JH815591) | 1055395..1055883 (+) | WP_154956507.1 |
Showing 1 to 3 of 3 rows
Experimental investigation has been performed.
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| ACP26819 | HMPREF1171_RS04695 (TecI) | chaperone | Aeromonas dhakensis strain SSU | chromosome (NZ_JH815591) | 1021066..1021794 (+) | WP_005299970.1 | HMPREF1171_RS04690 | HMPREF1171_RS04700 (TseI) |
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